Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation.
Front Cell Infect Microbiol
; 12: 845368, 2022.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1793038
ABSTRACT
Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical medical importance are characterized by highly inflammatory pathophysiology, involving severe pulmonary impairment and infection of multiple cell types within the body. Here, we discuss the interplay between coronaviruses and autophagy regarding virus life cycle, cell resistance, and inflammation, highlighting distinct mechanisms by which autophagy restrains inflammatory responses, especially those involved in coronavirus pathogenesis. We also address different autophagy modulators available and the rationale for drug repurposing as an attractive adjunctive therapy. We focused on pharmaceuticals being tested in clinical trials with distinct mechanisms but with autophagy as a common target. These autophagy modulators act in cell resistance to virus infection and immunomodulation, providing a double-strike to prevent or treat severe disease development and death from coronaviruses diseases.
Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Infecções por Coronavirus
/
Coronavirus
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Front Cell Infect Microbiol
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Fcimb.2022.845368
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