Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review.
J Autoimmun
; 132: 102898, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: covidwho-1996311
ABSTRACT
Autoimmunity linked to COVID-19 immunization has been recorded throughout the pandemic. Herein we present six new patients who experienced relapses of previous autoimmune disease (AD) or developed a new autoimmune or autoinflammatory condition following vaccination. In addition, we documented additional cases through a systematic review of the literature up to August 1st, 2022, in which 464 studies (928 cases) were included. The majority of patients (53.6%) were women, with a median age of 48 years (IQR 34 to 66). The median period between immunization and the start of symptoms was eight days (IQR 3 to 14). New-onset conditions were observed in 81.5% (n 756) of the cases. The most common diseases associated with new-onset events following vaccination were immune thrombocytopenia, myocarditis, and Guillain-Barré syndrome. In contrast, immune thrombocytopenia, psoriasis, IgA nephropathy, and systemic lupus erythematosus were the most common illnesses associated with relapsing episodes (18.5%, n 172). The first dosage was linked with new-onset events (69.8% vs. 59.3%, P = 0.0100), whereas the second dose was related to relapsing disease (29.5% vs. 59.3%, P = 0.0159). New-onset conditions and relapsing diseases were more common in women (51.5% and 62.9%, respectively; P = 0.0081). The groups were evenly balanced in age. No deaths were recorded after the disease relapsed, while 4.7% of patients with new-onset conditions died (P = 0.0013). In conclusion, there may be an association between COVID-19 vaccination and autoimmune and inflammatory diseases. Some ADs seem to be more common than others. Vaccines and SARS-CoV-2 may induce autoimmunity through similar mechanisms. Large, well-controlled studies are warranted to validate this relationship and assess additional variables such as genetic and other environmental factors.
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Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
/
Púrpura Trombocitopênica Idiopática
/
Vacinas contra COVID-19
/
COVID-19
/
Doenças do Sistema Imunitário
Tipo de estudo:
Relato de caso
/
Estudo experimental
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Estudo observacional
/
Estudo prognóstico
/
Ensaios controlados aleatorizados
/
Revisões
/
Revisão sistemática/Meta-análise
Tópicos:
Vacinas
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Meia-Idade
Idioma:
Inglês
Revista:
J Autoimmun
Assunto da revista:
Alergia e Imunologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
J.jaut.2022.102898
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