Update on nonpolio enterovirus and parechovirus infections in neonates and young infants.
Curr Opin Pediatr
; 35(3): 380-389, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: covidwho-20243856
ABSTRACT
PURPOSE OF REVIEW To review the epidemiology, clinical manifestations, and treatment strategies of nonpolio enterovirus and parechovirus (PeV) infections, and identify research gaps. RECENT FINDINGS:
There is currently no approved antiviral agent for enterovirus or PeV infections, although pocapavir may be provided on a compassionate basis. Elucidation of the structure and functional features of enterovirus and PeV may lead to novel therapeutic strategies, including vaccine development.SUMMARY:
Nonpolio human enterovirus and PeV are common childhood infections that are most severe among neonates and young infants. Although most infections are asymptomatic, severe disease resulting in substantial morbidity and mortality occurs worldwide and has been associated with local outbreaks. Long-term sequelae are not well understood but have been reported following neonatal infection of the central nervous system. The lack of antiviral treatment and effective vaccines highlight important knowledge gaps. Active surveillance ultimately may inform preventive strategies.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Enterovirus
/
Infecções por Picornaviridae
/
Parechovirus
/
Infecções por Enterovirus
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Covid persistente
/
Vacinas
Limite:
Criança
/
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Inglês
Revista:
Curr Opin Pediatr
Assunto da revista:
Pediatria
Ano de publicação:
2023
Tipo de documento:
Artigo
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