Fulminant varicella infection complicated by disseminated intravascular coagulation following influenza-A case report
Pediatric Dermatology
; 40(Supplement 2):47, 2023.
Artigo
em Inglês
| EMBASE | ID: covidwho-20244353
ABSTRACT
Objectives:
Varicella is common infectious disease mainly in childhood, usually is a mild, self-limited illness and complications are usually rare. The incubation period for this disease is generally 14- 16 days but may vary from 7 to 21 days. Varicella in the adults with comorbidities or immunosuppressed children may be severe and prolonged with complications. Method(s) A case report of a 6-year-old girl hospitalized for new-onset manifestations of disseminated vesicular exanthema, the manifestations of which occurred mainly on the chest, back, capillitium, oral cavity, and genital area. The child was suffering from abdominal, knee and lumbosacral pain at that time. The patient's history revealed that 10 days prior to the cutaneous manifestations, she had influenza with bronchopneumonia requiring oxygen therapy, steroids and antibiotics. Result(s) The condition progressed within 48 h, complicated by the development of multi-organ failure, coagulopathy with the development of disseminated intravascular coagulopathy over the course of antiviral, antibiotic and antifungal therapy. Laboratory parameters included high elevation of C-reactive protein, il-6, leukocytosis, neutrophilia and highly elevated liver enzymes. Varicella infection was confirmed by detection of herpes zoster virus - polymerase chain reaction (PCR) from vesicles. The patient received intravenous immunoglobulin therapy at a dose of 2 g/L and fresh frozen plasma, thrombocyte concentrate. The girl was intubated with analogization. Laboratory parameters subsequently revealed high anti CoV-2 positivity, high CoV-2 IgG positivity and negative CoV-2 IgM. The patient's condition did not preclude the course of multisystem inflammatory syndrome in children (MIS-C) corticosteroids were added to the treatment at a dose of 1 mg/kg weight. Patient's condition stabilized after 1 month. Discussion(s) Our case report presents an example of fulminant complicated life-threatening course of varicella. Even in common respiratory infections, we must think about the risk and consequences of coinfections and post-infectious complications such as in our case especially influenza and COVID-19.
antifungal therapy; blood clotting disorder; bronchopneumonia; case report; chickenpox; child; clinical article; coinfection; complication; conference abstract; coronavirus disease 2019; disseminated intravascular clotting; drug therapy; female; gene amplification; human; human tissue; hypertransaminasemia; infection complication; influenza; influenza A; knee; leukocytosis; low back pain; mouth cavity; multiple organ failure; neutrophilia; nonhuman; oxygen therapy; pediatric multisystem inflammatory syndrome; polymerase chain reaction; preschool child; respiratory tract infection; skin manifestation; thorax; thrombocyte; Varicella zoster virus; vesicular rash; antibiotic agent; antivirus agent; C reactive protein; corticosteroid; endogenous compound; fresh frozen plasma; human immunoglobulin; immunoglobulin G; immunoglobulin M; interleukin 6; thrombocyte concentrate
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
EMBASE
Tipo de estudo:
Relato de caso
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Pediatric Dermatology
Ano de publicação:
2023
Tipo de documento:
Artigo
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