Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection.
Nat Rev Immunol
; 23(6): 381-396, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: covidwho-20245248
ABSTRACT
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2 infection and have been suggested to be a useful correlate of protection for vaccine clinical trials and for population-level surveys. In addition to neutralizing virus directly, antibodies can also engage immune effectors through their Fc domains, including Fc receptor-expressing immune cells and complement. The outcome of these interactions depends on a range of factors, including antibody isotype-Fc receptor combinations, Fc receptor-bearing cell types and antibody post-translational modifications. A growing body of evidence has shown roles for these Fc-dependent antibody effector functions in determining the outcome of SARS-CoV-2 infection. However, measuring these functions is more complicated than assays that measure antibody binding and virus neutralization. Here, we examine recent data illuminating the roles of Fc-dependent antibody effector functions in the context of SARS-CoV-2 infection, and we discuss the implications of these data for the development of next-generation SARS-CoV-2 vaccines and therapeutics.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
COVID-19
Tipo de estudo:
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Vacinas
Limite:
Humanos
Idioma:
Inglês
Revista:
Nat Rev Immunol
Assunto da revista:
Alergia e Imunologia
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
S41577-022-00813-1
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