Clinical analysis of liver dysfunction in pregnant patients with mild SARS CoV-2 infection
Maturitas
; 173:97, 2023.
Artigo
em Inglês
| EMBASE | ID: covidwho-20245353
ABSTRACT
Objective:
The current study aimed to describe the clinical characteristics of mild SARS-CoV-2 infected pregnant women with abnormal liver function (ALF), explore the association between ALF with maternal and fetal outcomes. Method(s) This retrospective analysis included 87 pregnant patients with mild SARS-CoV-2 infection admitted and treated from December 1, 2022, to 31, 2022 in the department of Obestircs at Beijing Obstetrics and Gynecology Hospital. We evaluated patients for demographic and clinical features, laboratory parameters and pregnancy complications. Result(s) 27 Patients in this cohort had clinical presentations of ALF. Compared with the control group, the peripheral blood platelet (PLT), D-dimer quantitative determination (D-Dimer), lactate dehydrogenase (LDH), total protein (TP), albumin (ALB), indirect bilirubin (DBIL), gamma- glutamyltranspeptidase (GGT) and total bile acid (TBA) showed significantly differences (p<0.05). 12 cases (44.44%) complicated with pregnancy induced hypertension (PIH), 14 cases (51.85%) complicated with intrahepatic cholestasis of pregnancy (ICP), 2 cases (7.4%) complicated with acute fatty liver during pregnancy (AFLP) and 5 cases (14.81%) complicated with postpartum hemorrhage in patients with abnormal LFT were significantly higher than those in the control group (p<0.05). Compared with the control group, the incidence of premature delivery (22.22%) and fetal distress (37.04%) in the experiment group were significantly higher (p<0.05), and the incidence of neonatal asphyxia was not significantly different (p>0.05). Conclusion(s) Pregnant women are generally susceptible to mild SARS-CoV-2 and may induce ALF. ALF is associated with increased risk of mother and infant. The maternal and infant outcomes of those who terminated pregnancy in time are acceptable. Therefore, pregnant women with COVID-19 who received antiviral treatment should be closely monitored for evaluating liver function and relevant indicators. The long-term outcomes in the future are worth to further study.Copyright © 2023
adult; antiviral therapy; China; clinical evaluation; clinical feature; cohort analysis; complication; conference abstract; controlled study; coronavirus disease 2019; demography; fatty liver; female; fetus; fetus distress; fetus outcome; gynecology; human; hypertension; incidence; infant; intrahepatic cholestasis of pregnancy; liver dysfunction; liver function; major clinical study; nonhuman; obstetrics; outcome assessment; perinatal asphyxia; postpartum hemorrhage; pregnancy; pregnancy complication; pregnant woman; premature labor; quantitative analysis; retrospective study; Severe acute respiratory syndrome coronavirus 2; thrombocyte; albumin; bile acid; bilirubin; D dimer; endogenous compound; gamma glutamyltransferase; lactate dehydrogenase; protein
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
EMBASE
Tipo de estudo:
Estudo de coorte
/
Estudo experimental
/
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Maturitas
Ano de publicação:
2023
Tipo de documento:
Artigo
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