Pharmacological properties and derivatives of saikosaponins-a review of recent studies.
J Pharm Pharmacol
; 75(7): 898-909, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: covidwho-20245412
ABSTRACT
OBJECTIVES:
Saikosaponins (SSs) constitute a class of medicinal monomers characterised by a triterpene tricyclic structure. Despite their potential therapeutic effects for various pathological conditions, the underlying mechanisms of their actions have not been systematically analysed. Here, we mainly review the important anti-inflammatory, anticancer, and antiviral mechanisms underlying SS actions.METHODS:
Information from multiple scientific databases, such as PubMed, the Web of Science, and Google Scholar, was collected between 2018 and 2023. The search term used was saikosaponin. KEYFINDINGS:
Numerous studies have shown that Saikosaponin A exerts anti-inflammatory effects by modulating cytokine and reactive oxygen species (ROS) production and lipid metabolism. Moreover, saikosaponin D exerts antitumor effects by inhibiting cell proliferation and inducing apoptosis and autophagy, and the antiviral mechanisms of SSs, especially against SARS-CoV-2, have been partially revealed. Interestingly, an increasing body of experimental evidence suggests that SSs show the potential for use as anti-addiction, anxiolytic, and antidepressant treatments, and therefore, the related molecular mechanisms warrant further study.CONCLUSIONS:
An increasing amount of data have indicated diverse SS pharmacological properties, indicating crucial clues for future studies and the production of novel saikosaponin-based anti-inflammatory, efficacious anticancer, and anti-novel-coronavirus agents with improved efficacy and reduced toxicity.Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Ácido Oleanólico
/
Saponinas
/
COVID-19
Tipo de estudo:
Revisões
Limite:
Humanos
Idioma:
Inglês
Revista:
J Pharm Pharmacol
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Jpp
Similares
MEDLINE
...
LILACS
LIS