The relationship between SARS-CoV-2 vaccination and COVID-19 in children
China Tropical Medicine
; 23(4):338-341, 2023.
Artigo
em Chinês
| GIM | ID: covidwho-20245452
ABSTRACT
Objective:
To analyze the vaccination status of SARS-CoV-2 in children, and explore the relationship between SARS-CoV-2 vaccination and COVID-19 in children.Methods:
A retrospective study was conducted to analyze the clinical data of 335 cases of SARS-CoV-2 Omicron variant infection from February 15, 2022 to March 18, 2022 in Shenzhen Third People's Hospital.Results:
Among 335 children with SARS-CoV-2 infection, 174(51.9%) cases were vaccinated with the SARS-CoV-2 vaccine;33(31.4%) cases were vaccinated in the 3-<6 years old group;141(61.3%) cases were vaccinated in the 6-<14 years old group. There was a statistically significant difference in the proportion of SARS-CoV-2 vaccination between the 6-<14 years old group and the 3-<6 years old group (X2=26.1, P < 0.05). In the study cohort, 3-<6 years old group and 6-<14 years old group, there was no significant difference in the incidence of COVID-19 in the vaccinated group compared with the unvaccinated group (P > 0.05). In the study cohort, the proportion of confirmed cases of 1 dose of SARS-CoV-2 vaccine and 2 doses or more of SARS-CoV-2 vaccine was 89.5% (68 cases) and 77.6% (76 cases), respectively;in the 6~<14 years old group, the proportion of confirmed cases of 1 dose of SARS-CoV-2 vaccine and 2 doses or more of SARS-CoV-2 vaccine was 90.0% (54 cases) and 76.5% (62 cases), respectively;the differences were statistically significant (X2=4.264, P < 0.05;X2=4.279, P < 0.05). The IgG levels of 18.28 (6.61, 55.2) AU/mL and 58.3 (25.85, 131.41) AU/mL in the study cohort who were vaccinated for 1 dose, 2 doses and more, respectively;the IgG levels of 20.13 (8.33, 44.33) AU/mL and 56.57 (25.85, 150.07) AU/mL in the 6~<14 years old group who were vaccinated for 1 dose, 2 doses and more, respectively;and the differences were statistically significant (Z=-4.37, P < 0.05;Z=-3.96, P < 0.05).Conclusions:
Children who received 2 doses of SARS-CoV-2 vaccine have a lower incidence of COVID-19 and higher levels of SARS-CoV-2 antibodies compared with who received 1 dose. It is recommended that children are advised to be vaccinated against the COVID-19.
coronavirus disease 2019; human diseases; viral diseases; vaccination; children; pandemics; immunization; vaccines; disease prevention; health protection; retrospective studies; infectious diseases; dosage; immune sensitization; Severe acute respiratory syndrome coronavirus 2; man; Guangdong; China; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Central Southern China; APEC countries; East Asia; Asia; high Human Development Index countries; upper-middle income countries; SARS-CoV-2 variants; SARS-CoV-2; viral infections; Kwantung; People's Republic of China; communicable diseases
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
GIM
Tipo de estudo:
Estudo de coorte
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Vacinas
/
Variantes
Idioma:
Chinês
Revista:
China Tropical Medicine
Ano de publicação:
2023
Tipo de documento:
Artigo
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