Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection.
Cell Rep Med
; 2(4): 100228, 2021 04 20.
Artigo
em Inglês
| MEDLINE | ID: covidwho-2247733
ABSTRACT
Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence of antibody titers declining rapidly after infection and reports of reinfection. Here, we monitor the antibody responses against SARS-CoV-2 receptor-binding domain (RBD) for up to 6 months after infection. While antibody titers are maintained, â¼13% of the cohort's neutralizing responses return to background. However, encouragingly, in a selected subset of 13 participants, 12 have detectable RBD-specific memory B cells and these generally are increasing out to 6 months. Furthermore, we are able to generate monoclonal antibodies with SARS-CoV-2 neutralizing capacity from these memory B cells. Overall, our study suggests that the loss of neutralizing antibodies in plasma may be countered by the maintenance of neutralizing capacity in the memory B cell repertoire.
Palavras-chave
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Neutralizantes
/
Glicoproteína da Espícula de Coronavírus
/
SARS-CoV-2
/
COVID-19
/
Células B de Memória
Tipo de estudo:
Estudo de coorte
/
Estudo observacional
/
Estudo prognóstico
Tópicos:
Covid persistente
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Meia-Idade
/
Jovem adulto
Idioma:
Inglês
Revista:
Cell Rep Med
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
J.xcrm.2021.100228
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