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Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study (preprint)
researchsquare; 2022.
Preprint
em Inglês
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2284700.v1
ABSTRACT
This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score <48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.
Texto completo:
Disponível
Coleções:
Preprints
Base de dados:
PREPRINT-RESEARCHSQUARE
Assunto principal:
Transtornos de Ansiedade
/
Transtorno Depressivo
/
Fadiga
/
COVID-19
Idioma:
Inglês
Ano de publicação:
2022
Tipo de documento:
Preprint
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