Búsqueda | Biblioteca Virtual en Salud

1.

Antihypertensive treatment guided by genetics: PEARL-HT, the randomized proof-of-concept trial comparing rostafuroxin with losartan.

Citterio, Lorena; Bianchi, Giuseppe; Scioli, Giuseppe A; Glorioso, Nicola; Bigazzi, Roberto; Cusi, Daniele; Staessen, Jan A; Cavuto, Silvio; Ferrandi, Mara; Lanzani, Chiara; Li, Xiaoyi; Lau, Lit-Fui; Chiang, Chern-En; Wang, Tzung-Dau; Wang, Kang-Ling; Ferrari, Patrizia; Manunta, Paolo.

Pharmacogenomics J ; 21(3): 346-358, 2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-33649520

2.

Γ-secretase modulators do not induce Aß-rebound and accumulation of ß-C-terminal fragment.

Li, Ting; Huang, Yunhong; Jin, Shiyi; Ye, Liang; Rong, Na; Yang, Xiujuan; Ding, Yu; Cheng, Ziqiang; Zhang, Jinqiang; Wan, Zehong; Harrison, David C; Hussain, Ishrut; Hall, Adrian; Lee, Daniel Hong Seng; Lau, Lit-Fui; Matsuoka, Yasuji.

J Neurochem ; 121(2): 277-86, 2012 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-22035227

3.

Pyridazine-derived Î³-secretase modulators.

Wan, Zehong; Hall, Adrian; Jin, Yun; Xiang, Jia-Ning; Yang, Eric; Eatherton, Andrew; Smith, Beverley; Yang, Guang; Yu, Haihua; Wang, Ju; Ye, Liang; Lau, Lit-Fui; Yang, Ting; Mitchell, William; Cai, Wei; Zhang, Xiaomin; Sang, Yingxia; Wang, Yonghui; Tong, Zhaolong; Cheng, Ziqiang; Hussain, Ishrut; Elliott, John D; Matsuoka, Yasuji.

Bioorg Med Chem Lett ; 21(13): 4016-9, 2011 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-21636276

4.

Pyridine-derived Î³-secretase modulators.

Wan, Zehong; Hall, Adrian; Sang, Yingxia; Xiang, Jia-Ning; Yang, Eric; Smith, Beverley; Harrison, David C; Yang, Guang; Yu, Haihua; Price, Helen S; Wang, Jian; Hawkins, Julie; Lau, Lit-Fui; Johnson, Matthew R; Li, Tina; Zhao, Wei; Mitchell, William L; Su, Xiaobo; Zhang, Xiaomin; Zhou, Yanjiao; Jin, Yun; Tong, Zhaolong; Cheng, Ziqiang; Hussain, Ishrut; Elliott, John D; Matsuoka, Yasuji.

Bioorg Med Chem Lett ; 21(16): 4832-5, 2011 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-21742495

5.

Treatment with 24 hour istaroxime infusion in patients hospitalised for acute heart failure: a randomised, placebo-controlled trial.

Carubelli, Valentina; Zhang, Yuhui; Metra, Marco; Lombardi, Carlo; Felker, G Michael; Filippatos, Gerasimos; O'Connor, Christopher M; Teerlink, John R; Simmons, Phillip; Segal, Robert; Malfatto, Gabriella; La Rovere, Maria Teresa; Li, Dianfu; Han, Xiumin; Yuan, Zuyi; Yao, Yali; Li, Benjamin; Lau, Lit Fui; Bianchi, Giuseppe; Zhang, Jian.

Eur J Heart Fail ; 22(9): 1684-1693, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-31975496

6.

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

Wen, Yi; Planel, Emmanuel; Herman, Mathieu; Figueroa, Helen Y; Wang, Lili; Liu, Li; Lau, Lit-Fui; Yu, Wai Haung; Duff, Karen E.

J Neurosci ; 28(10): 2624-32, 2008 Mar 05.

Artículo en Inglés | MEDLINE | ID: mdl-18322105

7.

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

Noble, Wendy; Olm, Vicki; Takata, Kazuyuki; Casey, Evelyn; Mary, O; Meyerson, Jordana; Gaynor, Kate; LaFrancois, John; Wang, Lili; Kondo, Takayuki; Davies, Peter; Burns, Mark; Nixon, Ralph; Dickson, Dennis; Matsuoka, Yasuji; Ahlijanian, Michael; Lau, Lit-Fui; Duff, Karen.

Neuron ; 38(4): 555-65, 2003 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-12765608

8.

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

Planel, Emmanuel; Richter, Karl E G; Nolan, Charles E; Finley, James E; Liu, Li; Wen, Yi; Krishnamurthy, Pavan; Herman, Mathieu; Wang, Lili; Schachter, Joel B; Nelson, Robert B; Lau, Lit-Fui; Duff, Karen E.

J Neurosci ; 27(12): 3090-7, 2007 Mar 21.

Artículo en Inglés | MEDLINE | ID: mdl-17376970

9.

In Vitro and In Vivo Anticancer Activity of Gimatecan against Hepatocellular Carcinoma

Zhao, Youna; Lau, Lit-Fui; Dai, Xiangrong; Li, Benjamin.

Asian Pac J Cancer Prev ; 17(11): 4853-4856, 2016 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-28030910

10.

Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand.

Chung, Hee Jung; Huang, Yan Hua; Lau, Lit-Fui; Huganir, Richard L.

J Neurosci ; 24(45): 10248-59, 2004 Nov 10.

Artículo en Inglés | MEDLINE | ID: mdl-15537897

11.

A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury.

Li, Ting-Ting; Fan, Man-Li; Hou, Shi-Xiang; Li, Xiao-Yi; Barry, Devin M; Jin, Hui; Luo, Sheng-Yong; Kong, Feng; Lau, Lit-Fui; Dai, Xiang-Rong; Zhang, Guo-Hui; Zhou, Lan-Lan.

Br J Pharmacol ; 172(15): 3904-16, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-25917571

12.

Tau protein phosphorylation as a therapeutic target in Alzheimer's disease.

Lau, Lit-Fui; Schachter, Joel B; Seymour, Patricia A; Sanner, Mark A.

Curr Top Med Chem ; 2(4): 395-415, 2002 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-11966463

13.

Cdk5 as a drug target for the treatment of Alzheimer's disease.

Lau, Lit-Fui; Seymour, Patricia A; Sanner, Mark A; Schachter, Joel B.

J Mol Neurosci ; 19(3): 267-73, 2002 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-12540052

14.

Orally bioavailable and brain-penetrant pyridazine and pyridine-derived Î³-secretase modulators reduced amyloidogenic Aß peptides in vivo.

Huang, Yunhong; Li, Ting; Eatherton, Andrew; Mitchell, William L; Rong, Na; Ye, Liang; Yang, Xiu-Juan; Jin, Shiyi; Ding, Yu; Zhang, Jinqiang; Li, Yi; Wu, Yiwen; Jin, Yun; Sang, Yingxia; Cheng, Ziqiang; Browne, Edward R; Harrison, David C; Hussain, Ishrut; Wan, Zehong; Hall, Adrian; Lau, Lit-Fui; Matsuoka, Yasuji.

Neuropharmacology ; 70: 278-86, 2013 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-23485401

15.

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.

Wen, Yi; Yu, W Haung; Maloney, Bryan; Bailey, Jason; Ma, Junrong; Marié, Isabelle; Maurin, Thomas; Wang, Lili; Figueroa, Helen; Herman, Mathieu; Krishnamurthy, Pavan; Liu, Li; Planel, Emmanuel; Lau, Lit-Fui; Lahiri, Debomoy K; Duff, Karen.

Neuron ; 57(5): 680-90, 2008 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-18341989

16.

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

Lanz, Thomas A; Karmilowicz, Michael J; Wood, Kathleen M; Pozdnyakov, Nikolay; Du, Ping; Piotrowski, Mary A; Brown, Tracy M; Nolan, Charles E; Richter, Karl E G; Finley, James E; Fei, Qing; Ebbinghaus, Charles F; Chen, Yuhpyng L; Spracklin, Douglas K; Tate, Barbara; Geoghegan, Kieran F; Lau, Lit-Fui; Auperin, David D; Schachter, Joel B.

J Pharmacol Exp Ther ; 319(2): 924-33, 2006 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-16920992

17.

Role of cdk5 in the pathogenesis of Alzheimer's disease.

Lau, Lit-Fui; Ahlijanian, Michael K.

Neurosignals ; 12(4-5): 209-14, 2003.

Artículo en Inglés | MEDLINE | ID: mdl-14673207

18.

Alzheimer's Disease

Lau, Lit-Fui.

Berlin, Heidelberg; Springer Berlin Heidelberg; 2008.

Monografía en Inglés | Bibliografia | ID: bib-350781

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