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1.
Med. oral patol. oral cir. bucal (Internet) ; 19(1): e32-e38, ene. 2014. ilus, tab
Article in English | IBECS | ID: ibc-118250

ABSTRACT

OBJECTIVES: To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil. Study DESIGN: Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV).RESULTS: Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis. CONCLUSIONS: Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinico-pathologic features to those described in endemic areas of Africa, including EBV positivity


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Subject(s)
Humans , Burkitt Lymphoma/epidemiology , Mandibular Neoplasms/epidemiology , Age and Sex Distribution , Brazil/epidemiology
2.
Med Oral Patol Oral Cir Bucal ; 19(1): e32-8, 2014 Jan 01.
Article in English | MEDLINE | ID: mdl-23986017

ABSTRACT

OBJECTIVE: To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil. STUDY DESIGN: Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV). RESULTS: Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis. CONCLUSION: Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinicopathologic features to those described in endemic areas of Africa, including EBV positivity.


Subject(s)
Burkitt Lymphoma/pathology , Jaw Neoplasms/pathology , Adolescent , Adult , Brazil , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Young Adult
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