1.
Mem Inst Oswaldo Cruz
; 104(5): 703-5, 2009 Aug.
Article
in English
| MEDLINE
| ID: mdl-19820828
ABSTRACT
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.
Subject(s)
Amino Alcohols/pharmacology , Antitubercular Agents/pharmacology , Diamines/pharmacology , Mycobacterium tuberculosis/drug effects , Amino Alcohols/chemical synthesis , Antitubercular Agents/chemistry , Diamines/chemical synthesis , Microbial Sensitivity Tests
2.
Mem. Inst. Oswaldo Cruz
; 104(5): 703-705, Aug. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-528076
ABSTRACT
A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
