Costs and mortality rates of surgical approaches to hysterectomy in Brazil.

OBJECTIVE: To analyze the costs of hysterectomies performed in Brazil due to benign conditions, and to assess its hospital admittance and mortality rates. METHODS: A retrospective cohort was carried out from January 2010 to December 2014, analyzing all hysterectomies (n = 428,346) registered on the DATASUS database between January 2010 and December 2014. Data were collected through a structured questionnaire and analyzed using the SPSS 20.0 for Windows. RESULTS: Hospital admissions were 300,231 for total abdominal hysterectomies, 46,056 for vaginal hysterectomies, 29,959 for subtotal abdominal hysterectomies and 1,522 for laparoscopic hysterectomies. Mortality rates were 0.26%, 0.09%, 0.07% and 0.05% for subtotal, total abdominal, laparoscopic, and vaginal hysterectomies, respectively. Among the procedures studied, total abdominal hysterectomies had the most costs (R$217,802,574.77), followed by vaginal hysterectomies (R$24,173,490.00), subtotal abdominal hysterectomies (R$19.253.300,00) and laparoscopic hysterectomies (R$794,680.40). CONCLUSIONS: Total abdominal hysterectomies had the highest overall costs mainly because it was the most commonly performed technique. Mortality rates were greatest in subtotal abdominal hysterectomies; this, however, may be due to bias related to missing data in our database.

Ascites and Encapsulating Peritonitis in Endometriosis: a Systematic Review with a Case Report.

Endometriosis can have several different presentations, including overt ascites and peritonitis; increased awareness can improve diagnostic accuracy and patient outcomes. We aim to provide a systematic review and report a case of endometriosis with this unusual clinical presentation. The PubMed/MEDLINE database was systematically reviewed until October 2016. Women with histologically-proven endometriosis presenting with clinically significant ascites and/or frozen abdomen and/or encapsulating peritonitis were included; those with potentially confounding conditions were excluded. Our search yielded 37 articles describing 42 women, all of reproductive age. Ascites was mostly hemorrhagic, recurrent and not predicted by cancer antigen 125 (CA-125) levels. In turn, dysmenorrhea, dyspareunia and infertility were not consistently reported. The treatment choices and outcomes were different across the studies, and are described in detail. Endometriosis should be a differential diagnosis of massive hemorrhagic ascites in women of reproductive age.

A endometriose pode ter várias apresentações, incluindo ascite e peritonite, que são apresentações incomuns. O aumento da conscientização sobre essa doença pode melhorar a precisão diagnóstica e os resultados das pacientes. Nosso objetivo é fornecer uma revisão sistemática e relatar um caso de endometriose com esta apresentação clínica incomum. O banco de dados PubMed/MEDLINE foi revisado sistematicamente até outubro de 2016. Foram incluídas mulheres com endometriose demonstrada histologicamente, com presença de ascite clinicamente significativa e/ou abdômen congelado e/ou peritonite encapsulante; foram excluídas aquelas com comorbidades que pudessem provocar confusão. A pesquisa selecionou 37 artigos que descrevem 42 mulheres, todas em idade reprodutiva. A ascite foi principalmente hemorrágica, recorrente, e não indicada pelos níveis de antígeno associado ao câncer 125 (AC-125). Por sua vez, a dismenorreia, a dispareunia e a infertilidade não foram relatadas de forma consistente. As escolhas e os resultados do tratamento foram diferentes entre os estudos, e são descritos em detalhes. A endometriose deveria ser um diagnóstico diferencial de ascite hemorrágica maciça em mulheres em idade reprodutiva.

Ascites and Encapsulating Peritonitis in Endometriosis: a Systematic Review with a Case Report / Endometriose com ascite e peritonite encapsulante: uma revisão sistemática com descrição de um caso clínico

Abstract Endometriosis can have several different presentations, including overt ascites and peritonitis; increased awareness can improve diagnostic accuracy and patient outcomes. We aimto provide a systematic review and report a case of endometriosis with this unusual clinical presentation. The PubMed/MEDLINE database was systematically reviewed until October 2016. Women with histologically-proven endometriosis presenting with clinically significant ascites and/or frozen abdomen and/or encapsulating peritonitis were included; thosewith potentially confounding conditionswere excluded.Our search yielded 37 articles describing 42 women, all of reproductive age. Ascites was mostly hemorrhagic, recurrent and not predicted by cancer antigen 125 (CA-125) levels. In turn, dysmenorrhea, dyspareunia and infertility were not consistently reported. The treatment choices and outcomes were different across the studies, and are described in detail. Endometriosis should be a differential diagnosis of massive hemorrhagic ascites in women of reproductive age.

Resumo A endometriose pode ter várias apresentações, incluindo ascite e peritonite, que são apresentações incomuns. O aumento da conscientização sobre essa doença podemelhorar a precisão diagnóstica e os resultados das pacientes. Nosso objetivo é fornecer uma revisão sistemática e relatar um caso de endometriose com esta apresentação clínica incomum. O banco de dados PubMed/MEDLINE foi revisado sistematicamente até outubro de 2016. Foram incluídas mulheres comendometriosedemonstrada histologicamente, compresença de ascite clinicamente significativa e/ou abdômen congelado e/ou peritonite encapsulante; foram excluídas aquelas com comorbidades que pudessem provocar confusão. A pesquisa selecionou 37 artigos que descrevem42mulheres, todas emidade reprodutiva. A ascite foi principalmente hemorrágica, recorrente, e não indicada pelos níveis de antígeno associado ao câncer 125 (AC-125). Por sua vez, a dismenorreia, a dispareunia e a infertilidade não foram relatadas de forma consistente. As escolhas e os resultados do tratamento foram diferentes entre os estudos, e são descritos em detalhes. A endometriose deveria ser um diagnóstico diferencial de ascite hemorrágica maciça em mulheres em idade reprodutiva.

Pelvic floor muscle function and quality of life in postmenopausal women with and without pelvic floor dysfunction.

INTRODUCTION: This study aims to compare pelvic floor muscle (PFM) function in postmenopausal women with and without pelvic floor dysfunction (PFD) and the relation between PFM function and quality of life. MATERIAL AND METHODS: A case-control study with 216 postmenopausal women with (n = 126) and without (n = 90) PFD. PFM function was assessed by digital vaginal palpation using the PERFECT scale. Specific quality of life was evaluated using the King's Health Questionnaire for women with urinary incontinence and the Prolapse Quality-of-Life Questionnaire for women with pelvic organ prolapse. We analyzed women with PFD into two categories: Oxford's grade ≤2 or ≥3 using a chi-squared test. RESULTS: Out of 126 womem with PFD 44 (34.9%) presented stress urinary incontinence, 21 (16.6%) had pelvic organ prolapse and 61 (48.4%) had urinary incontinence + pelvic organ prolapse. Strength had a median value 2 (0-5) in all women studied and most of them had insufficient strength, reduced endurance and repetition without statistical difference between groups. Incontinent women with strength ≤2 had worse perception of general health domain of King's Health Questionnaire (p = 0.007). No association was found between PFM function and Prolapse Quality-of-Life Questionnaire. CONCLUSIONS: PFM function assessed by bidigital palpation in postmenopausal women was not sufficiently sensitive to differentiate between women with vs. women without PFM dysfunction and was not related with specific quality of life in women with urinary incontinence and pelvic organ prolapse, respectively. These data should be used to reinforce the widespread recommendation that PFM training is essencial in PFD treatment.

Costs and mortality rates of surgical approaches to hysterectomy in Brazil

ABSTRACT OBJECTIVE To analyze the costs of hysterectomies performed in Brazil due to benign conditions, and to assess its hospital admittance and mortality rates. METHODS A retrospective cohort was carried out from January 2010 to December 2014, analyzing all hysterectomies (n = 428,346) registered on the DATASUS database between January 2010 and December 2014. Data were collected through a structured questionnaire and analyzed using the SPSS 20.0 for Windows. RESULTS Hospital admissions were 300,231 for total abdominal hysterectomies, 46,056 for vaginal hysterectomies, 29,959 for subtotal abdominal hysterectomies and 1,522 for laparoscopic hysterectomies. Mortality rates were 0.26%, 0.09%, 0.07% and 0.05% for subtotal, total abdominal, laparoscopic, and vaginal hysterectomies, respectively. Among the procedures studied, total abdominal hysterectomies had the most costs (R$217,802,574.77), followed by vaginal hysterectomies (R$24,173,490.00), subtotal abdominal hysterectomies (R$19.253.300,00) and laparoscopic hysterectomies (R$794,680.40). CONCLUSIONS Total abdominal hysterectomies had the highest overall costs mainly because it was the most commonly performed technique. Mortality rates were greatest in subtotal abdominal hysterectomies; this, however, may be due to bias related to missing data in our database.

Defecatory dysfunction and fecal incontinence in women with or without posterior vaginal wall prolapse as measured by pelvic organ prolapse quantification (POP-Q).

INTRODUCTION AND HYPOTHESIS: Pelvic Floor Dysfunction is a complex condition that may be asymptomatic or may involve a loto f symptoms. This study evaluates defecatory dysfunction, fecal incontinence, and quality of life in relation to presence of posterior vaginal prolapse. METHODS: 265 patients were divided into two groups according to posterior POP-Q stage: posterior POP-Q stage ≥2 and posterior POP-Q stage <2. The two groups were compared regarding demographic and clinical data; overall POP-Q stage, percentage of patients with defecatory dysfunction, percentage of patients with fecal incontinence, pelvic floor muscle strength, and quality of life scores. The correlation between severity of the prolapse and severity of constipation was calculated using ρ de Spearman (rho). RESULTS: Women with Bp stage ≥2 were significantly older and had significantly higher BMI, numbers of pregnancies and births, and overall POP-Q stage than women with stage <2. No significant differences between the groups were observed regarding proportion of patients with defecatory dysfunction or incontinence, pelvic floor muscle strength, quality of life (ICIQ-SF), or sexual impact (PISQ-12). POP-Q stage did not correlate with severity of constipation and incontinence. General quality of life perception on the SF-36 was significantly worse in patients with POP-Q stage ≥2 than in those with POP-Q stage <2. CONCLUSIONS: The lack of a clinically important association between the presence of posterior vaginal prolapse and symptoms of constipation or anal incontinence leads us to agree with the conclusion that posterior vaginal prolapse probably is not an independent cause defecatory dysfunction or fecal incontinence.

Endometriosis and Ovarian Cancer: an Integrative Review (Endometriosis and Ovarian Cancer)

Despite being initially considered a benign disease, it is widely thought nowadays that endometriosis and especially ovarian endometriomas are neoplastic conditions with the potential to become malignant. This review was conducted to summarize, in a concise and systematic manner, the available scientific data relating endometriosis to ovarian cancer, published in the past five years. After reading abstracts and applying our predefined inclusion and exclusion criteria, a final list of 11 scientific papers was obtained and subjected to review. Endometriosis is associated with an increased risk of developing epithelial ovarian cancer (EOC), mainly of endometrioid and clear cell subtypes. This might be by virtue of the high estrogen concentration with the disease, which leads to malignant proliferation of endometriotic cysts, or be due to mutations in the ARID1A gene and consequent loss of BAF250a expression. The iron produced in the fluid of endometriotic cysts promotes oxidative stress, which in turn may cause genetic mutations and malignant progression of ovarian cysts.

Prevalence of unreported bowel symptoms in women with pelvic floor dysfunction and the impact on their quality of life.

INTRODUCTION AND HYPOTHESIS: Little information is available on the recurrent coexistence of pelvic organ prolapse (POP), urinary (UI) and/or anal (AI) incontinence and defecatory dysfunctions and the relationship between these disorders. The purpose of this study is to report the prevalence, bother, and impact on quality of life (QoL) of unreported bowel symptoms in women presenting to a Brazilian tertiary urogynecology clinic. METHODS: The study was a cross-section survey of 172 patients with symptoms of pelvic floor disorders (PFD). Patients who reported any defecatory and/or continence disorders were included in the study group, and the others were included in the control group. Patients with UI were also compared with those with double incontinence (DI): AI and UI. Univariate analysis was conducted using the Mann-Whitney U test for continuous nonparametric data. RESULTS: After the interview, 54.6 % (n = 94) of patients presented AI and/or defecatory disorders: 67.0 % constipation, 41.4 % AI, and 34.0 % fecal urgency. Women from the study group scored worse in the QoL questionnaires compared with women from the control group. Among women with UI, 23.21 % had associated AI. Women with DI scored worse in the QoL questionnaires. CONCLUSION: Anal and urinary dysfunctions are usually associated and have a great impact on a woman's QoL. An integrated approach across specialties should lead to improved patient care. Therefore, our study is relevant because it emphasizes the importance of urogynecologists routinely investigating such symptoms. To do so, standardized questionnaires should be included in the evaluation of all these patients.

Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency / Influência da infecção por papillomavirus humano no microbioma vaginal de mulheres imunocompetentes

The influence of vaginal infections on the natural history of human papillomavirus (HPV) is still unclear. Objective: To determine if patientswith low-grade squamous intraepithelial lesions (LSILs) and HPV have more vulvovaginitis than patients with normal liquid-based cervical cytology whowere negative for HPV. Methods: This is a cross-sectional study including 322 patients who underwent cervical exams. One hundred and sixty-seven ofthese patients had LSILs on cervical cytology and were simultaneously hybrid capture 2 (HC2)-positive for HPV, and the remaining 155 patients were negative for malignancies and intraepithelial lesions by cytology and HC2-negative for HPV. The prevalence of vaginal infections in both groups was compared using the X2 test without Yates' correction. Results: Among the patients with HPV and LSILs, the most common vaginal infection was vaginosis(8.98%) compared to candidiasis (12.9%) in the patients without LSILs and HPV. No significant differences were found in the prevalence of vaginosisbetween the two groups (p=0.53). Candidiasis was statistically more prevalent in patients without LSILs and HPV (p<0.001). Conclusion: An associationwas found between the presence of Candida and the absence of HPV. Although vaginosis was more frequent among patients with LSILs and HPV, it wasnot statistically significant.

A influência das infecções vaginais na história natural do papillomavirus humano (HPV) ainda é incerta. Objetivo: Determinar se pacientes com lesões intraepiteliais escamosas de baixo grau (LIEBG) e HPV têm mais vulvovaginites que aquelas com citologia cervical em meio líquido normal e testes negativos para HPV. Métodos: Este é um estudo transversal, que incluiu 322 mulheres que fizeram exames de colo. Cento e sessenta e sete destas tinham LIEBG na citologia oncótica e foram simultaneamente positivas para HPV na captura híbrida 2 (CH2). As outras 155 tiveram citologias negativas para neoplasia intraepitelial e malignidade e eram CH2 negativas para HPV. A prevalência de infecção vaginal nos dois grupos foi comparada usando o teste do X2 sem correção de Yates. Resultados: Entre as pacientes com HPV e LIEBG, a infecção vaginal mais comum foi a vaginose (8,98%), enquantoque, no grupo sem LIEBG e sem HPV, foi a candidíase (12,9%). Nenhuma diferença estatisticamente significante foi encontrada na prevalência de vaginose entre os dois grupos (p=0,53). Candidíase foi estatisticamente mais prevalente nas pacientes sem LIEBG e HPV (p<0,001). Conclusão: Foi encontrada uma associação entre a presença de Candida e a ausência de HPV. Embora a vaginose tenha sido mais frequente em pacientes com LIEBG e HPV, esse dado não foi estatisticamente significante.

[Relation doctor-patient in oncology: fears, anguishes and communication abilities among doctors in Fortaleza, Ceará State, Brazil]. / Relação médico-paciente em oncologia: medos, angústias e habilidades comunicacionais de médicos na cidade de Fortaleza (CE).

In oncology the doctor-patient relationship has a particular importance due to the gravity of the illness and to the stigma that is followed many times by the experience of the patient. This research was designed to analyze perceptions and difficulties that doctors face when they are dealing with oncology patient. It is a qualitative study, based mainly on open and in-depth interviews, involving 20 doctors from the Cancer Institute of Ceará. From the relationship of Dr. Sheila with her patients, Cássio and Elisa, fictitious personages of a chronicle larded in the quarrel of the article, the main facts are illustrated. We tried to approach four main subjects: the construction of the bond, the communication abilities performance, the therapeutic approach and the family interaction. The suffering and the emotional implications of patients and familiars, the differences in communication between the interviewed doctors, mainly in reference to the transmission of the diagnosis and the therapy, become important factors that influence the relation and the establishment or not of the therapeutic bond. Because of this, it seems to be necessary studies and debates concerning this subject, aiming at an incorporation of this thematic in the medical training.

Relação médico-paciente em oncologia: medos, angústias e habilidades comunicacionais de médicos na cidade de Fortaleza (CE) / Relation doctor-patient in oncology: fears, anguishes and communication abilities among doctors in Fortaleza, Ceará State, Brazil

A relação médico-paciente, em oncologia, adquire uma particular importância devido à gravidade da doença e ao estigma que muitas vezes acompanha a experiência do paciente. Esta pesquisa teve como objetivo analisar percepções e dificuldades que os médicos vivenciam frente ao paciente oncológico. Trata-se de um estudo qualitativo, baseado principalmente em entrevistas abertas e aprofundadas, realizado com vinte médicos que trabalham no Instituto do Câncer do Ceará. Baseando-se na convivência da Dra. Sheila com seus pacientes, Cássio e Elisa, personagens fictícios de uma crônica entremeada na discussão do artigo, ilustram-se os principais registros encontrados. Procurou-se abordar quatro temas centrais: a construção do vínculo, o desempenho de habilidades comunicacionais, a abordagem terapêutica e a interação com a família. O sofrimento e as implicações emocionais de pacientes e familiares, as diferenças comunicacionais existentes entre os médicos entrevistados, principalmente em referência à transmissão do diagnóstico e à terapêutica, tornam-se fatores importantes que influenciam a relação e o estabelecimento ou não do vínculo terapêutico. Diante disso, vê-se ser necessário estudos e debates acerca do tema, visando a uma incorporação desta temática na formação médica.

In oncology the doctor-patient relationship has a particular importance due to the gravity of the illness and to the stigma that is followed many times by the experience of the patient. This research was designed to analyze perceptions and difficulties that doctors face when they are dealing with oncology patient. It is a qualitative study, based mainly on open and in-depth interviews, involving 20 doctors from the Cancer Institute of Ceará. From the relationship of Dr. Sheila with her patients, Cássio and Elisa, fictitious personages of a chronicle larded in the quarrel of the article, the main facts are illustrated. We tried to approach four main subjects: the construction of the bond, the communication abilities performance, the therapeutic approach and the family interaction. The suffering and the emotional implications of patients and familiars, the differences in communication between the interviewed doctors, mainly in reference to the transmission of the diagnosis and the therapy, become important factors that influence the relation and the establishment or not of the therapeutic bond. Because of this, it seems to be necessary studies and debates concerning this subject, aiming at an incorporation of this thematic in the medical training.

A comunicação do diagnóstico "sombrio" na relação médico-paciente entre estudantes de Medicina: uma experiência de dramatização na educação médica / Communicating an unfavorable diagnosis during the physician-patient relationship: a role-playing experiment with medical students

O objetivo do trabalho foi apresentar a dramatização como prática para a humanização da relação médico- paciente entre estudantes do terceiro semestre do curso de Medicina da Universidade Estadual do Ceará (Uece). Por meio de metodologia qualitativa, aplicaram-se perguntas referentes aos sentimentos vivenciados enquanto na posição de médicos e de pacientes, e à vivência com a técnica, após a mesma ser apresentada em sala de aula (n=24).Os dados permitiram identificar que os temas abordados se referiam a doenças graves e perdas. Em relação aos sentimentos, no papel tanto de paciente quanto de médico, demonstraram angústia, impotência, apreensão,medo e ansiedade. Expressaram dificuldades frente ao diagnóstico e à transmissão de má notícia, ao mesmo tempo em que valorizaram a construção do vínculo médico-paciente. Frente à experiência, destacaram a técnica como geradora de auto conhecimento e vivência da futura profissão. Estudos prospectivos devem ser realizados para avaliar o impacto dessa estratégia na humanização da relação médico- paciente e educação médica, explorando o máximo de potencialidade frente às suas limitações.

The aim of this article is to present role-playing as apractice for humanization of the physician-patient relationship, as experienced by third-semester medical students at the State University of Ceará (UECE), Brazil. Using a qualitative methodology, questions were applied relating to the students' feelings while playing the roles of doctor and patient, respectively, and their experience with the technique after its presentation in the classroom (n = 24). According to the findings, the topics tha twere approached related to serious illnesses and losses. Both in the patient's and physician's role, the students felt anguish, powerlessness, apprehension, fear, and anxiety. They expressed difficulties towards both the diagnosis itself and communicating the bad news, even while they valued building and consolidating the physician-patient bond. As for the method, they highlighted its importance for generating self-knowledge and experience for their future profession. Prospective studies should be performed to evaluate the strategy's impact on the humanization of the physician-patient relationship and medical education, fully exploring its potential and limitations.

Educação e humanidades em saúde: a experiência do grupo de Humanidades do curso de Medicina da Universidade Estadual do Ceará (Uece) / Education and humanities in health: the experience of the Humanities group of the Medical course, Federal University of the State of Ceará (Uece)

Nos últimos anos, vem se desenvolvendo uma grande área de reflexão e pensamento, denominada "humanidades médicas", que incorpora a realidade social e a experiência individual à interface entre médico e paciente. O grupo Humanidades, Saberes e Práticas em Saúde nasce em 2004, como núcleo de desenvolvimento de pesquisas, composto por estudantes de Medicina, com o objetivo de explorar como a prática médica lida com as experiências de pacientes e de médicos e o processo saúde-doença. As linhas de ação envolvem pesquisa com médicos oncologistas e sua visão da relação médico-paciente na consulta oncológica e ensino no terceiro e quarto semestres do curso de Medicina, utilizando casos clínicos, modelo teórico e role play. Nessa perspectiva, busca-se aproximar a temática da relação médico-paciente do cotidiano dos estudantes de Medicina, contribuindo para desenvolver uma atitude humanizada frente ao ser humano portador de enfermidade.

During the past few years a great area of thought and reflection named medical humanities, incorporating social reality and individual experience to the doctor-patient relationship, has evolved. The group Humanidades, Saberes e Práticas - Humanities, Knowledge and Practices was born in 2004 as a research nucleus composed by medical students, with the intent of getting insight into how the medical practice is dealing with the experience of doctors and patients and with the health-disease process. The lines of action involve research with oncologists for obtaining their view about the doctor-patient relationship in the oncological consultation as well as about the use of clinical cases, theoretic model and role play as teaching strategies for medical students from the third and fourth semesters. From that perspective we are trying to approximate the issue doctor-patient relationship and the every-day routine of medical students in an attempt to contribute to the development of a humanized attitude towards the diseased human being.