An in Vitro Evaluation of Remineralizing Capacity of Self-Assembling Peptide (SAP) P11-4 and Casein Phosphopeptides-Amorphous Calcium Phosphate (CPP-ACP) on Artificial Enamel

Objective: To determine and compare the remineralizing capacity of self-assembling peptide (SAP) P11-4 and casein phosphopeptides­amorphous calcium phosphate (CPP-ACP) on enamel. Material and Methods: Enamel samples were divided into 2 groups. Group I was treated with Self­assembling peptide (SAP) P11-4 and group II with casein phosphopeptides-amorphous calcium phosphate (CPP-ACP). In both groups, remineralizing capacity was assessed at baseline, 2 weeks, 6 weeks and 12 weeks. Student's t- test and ANOVA were applied, with the significance level set at 5%. Results: The mean calcium weight % was evaluated at baseline, 2 weeks, 6 weeks and 12 weeks. In Group I, there was increase in mean value (62.12 ± 1.24) from baseline to 12 weeks (67.36 ± 2.14). However, there was decrease in phosphate weight % from 37.16 ± 2.52 at baseline to 35.72 ± 2.11 at 12 weeks. In Group II, mean calcium weight % was 64.18 ± 1.52 at baseline, which ultimately increased to 66.01 ± 2.03 at 12 weeks. Phosphate weight % showed reduction from 37.34 ± 2.23 at baseline to 35.04 ± 2.02 at 12 weeks. Ca/P ratio showed significant improvement. There was significant difference in Ca/P ratio at 2 weeks, 6 weeks and 12 weeks in both groups (p<0.05). Conclusion: Self-assembling peptide (SAP) P11-4 found to be more effective and efficient as compared to casein phosphopeptides­amorphous calcium phosphate (CPP-ACP).

Clinical and Histopathological Analysis of Odontogenic Tumors in Institution-A 10 Years Retrospective Study.

AIM: The present study was conducted to analyze the clinical and histopathological cases of odontogenic tumors (OTs). MATERIALS AND METHODS: The present 10-year retrospective study comprised of 104 OTs. Parameters such as name, age, gender, clinical features, location, extension, etc were noted. H and E stained slides were carefully assessed by an oral pathologist and were classified according to the latest WHO classification of head and neck tumors. RESULTS: Out of 104 OTs, the most common was ameloblastoma constituting 45 cases, KCOT (28), odontoma (17), odontogenic myxoma (4), Calcifying epithelial odontogenic tumor (CEOT) (5), cementoblastoma (3) and calcifying cystic odontogenic tumor (2). The p value found to be 0.01 (significant). Common OTs was ameloblastoma (25 males and 20 males), KCOT (12 males and 16 females), odontoma (10 males and 7 females), odontogenic myxoma (3 males and 1 female), CEOT (3 males and 2 females), cementoblastoma (2 males and 1 female) and calcifying cystic odontogenic tumor (1 male and 1 female). Ameloblastoma, KCOT, and odontoma were predominantly seen in the age group 21-30 years, CEOT and cementoblastoma in age group 31-40 years. The difference was significant (P < 0.05). Common clinical features in OTs were facial disfigurement (65), swelling (78) and pain (55). The difference was non significant (P > 0.05). The average size of ameloblastoma was 6.8cm, KCOT was 4.2 cm, odontoma was 3.9 cm, odontogenic myxoma was 2.7 cm, CEOT was 5.5 cm, cementoblastoma was 3.8 cm and Calcifying cystic odontogenic tumour (COC) was 3.6 cm. The difference was non-significant (p > 0.05). CONCLUSION: Mandible exhibited more OTs as compared to the maxilla. The most common lesion was ameloblastoma, KCOT, and odontomas. We observed male predominance. CLINICAL SIGNIFICANCE: The study helps in assessing the occurrence of the odontogenic tumor. This is useful for identification and clinical management.