ABSTRACT
Se muestra una revisión crítica de los metaanálisis que evalúan la eficacia de las estatinas en la prevención primaria de la enfermedad cardiovascular. Se realizaron búsquedas en MEDLINE, EMBASE y Cochrane (período: enero 2005 a diciembre de 2011) de metaanálisis de en sayos clínicos dirigidos a estudiar el efecto de las estatinas en la prevención primaria de la enfermedad cardiovascular. Se utilizó el cuestionario PRISMA para evaluar la precisión y fiabilidad de los metaanálisis. Se seleccionaron un total de 9 metaanálisis (promedio de pacientes: 88.006). Cinco estudios encontraron beneficio en los eventos cardiovasculares mayores (rango del riesgo relativo [RR]: 0,69-0,85). Siete metaanálisis obtuvieron mejoras en los eventos coronarios mayores (rango RR: 0,61-0,77). No hubo concordancia en los resultados de mortalidad total, mortalidad coronaria y accidentes cerebrovasculares. Esta revisión crítica de los últimos metaanálisis sugiere un modesto beneficio de las estatinas en la prevención primaria de la enfermedad cardiovascular (AU)
It shows a critical review of meta-analysis assessing the efficacy of statins in primary prevention of cardiovascular disease. We searched MEDLINE, EMBASE and Cochrane (period: January 2000 to December 2011) for meta-analysis of randomized trials conducted to study the effect of statins in primary prevention of cardiovascular disease. We used PRISMA statement to evaluate accuracy and reliability ofmeta-analysis. We selected 9 meta-analysis (mean of patients: 88.006). Five studies found a benefit in mayor cardiovascular events (range of relative risk [RR]: 0.69-0.85). Seven meta-analysis obtained improvement in mayor coronary events (range of RR: 0.61-0.77). There was no agreement between the results of total mortality, coronary mortality and cerebrovascular events. This critical review of meta-analysis suggests a modest benefit of statins in a primary prevention set-up (AU)
Subject(s)
Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Anticholesteremic Agents/therapeutic use , Cardiovascular Diseases/prevention & control , Risk Factors , Primary Prevention/methodsABSTRACT
OBJECTIVE: To estimate the prevalence and characteristics of geographic isolation in the elder people from Alora (Málaga). DESIGN: A transversal observational study. SETTING: Town of Alora. PATIENTS OR OTHER PARTICIPANTS: Elder people of both sexes, who lives habitually in Alora and born in 1927 or before. Home interview in a 153 individuals random sample proceeding from actual census during june to september 1992. MEASUREMENTS AND MAIN RESULTS: We found 25 individuals with the isolation conditions being the 16.34% (IC 95%: 10.48-22.20). In the 24% of them (IC 95%: 11.5-43.4) we found dependence of other person for two and more basic functions in the current life. Half of them this deficits are cover by the couple, the rest depends on their sons. We didn't found significative differences in none variables with the urban group. CONCLUSIONS: The geographic isolation affect to an important proportion of elder people in rural areas and must be used in the designs of care elderly programs.
