Hipotensión intracraneal secundaria a fístula espinal espontánea de líquido cefalorraquídeo: Presentación de tres casos / Intracranial hypotension secondary to spontaneous spinal cerebrospinal fluid fistula: Three case reports

El síndrome de hipotensión intracraneal espontánea (HIE) es una dolencia poco frecuente. El síntoma principal es la cefalea ortostática, si bien pueden aparecer otras manifestaciones como síntomas vegetativos, meningismo o déficits neurológicos focales. La causa más frecuente es una fístula de líquido cefalorraquídeo, generalmente traumática. Las fístulas de líquido cefalorraquídeo espontáneas son poco comunes y se relacionan con la presencia de quistes/divertículos meníngeos o en el contexto de enfermedades del tejido conectivo. El diagnóstico se basa en las pruebas de imagen, tanto para detectar complicaciones intracraneales, como los hematomas subdurales bilaterales y para localizar el punto de fuga a nivel intracraneal o espinal. El tratamiento de la HIE suele ser conservador mediante reposo postural, cafeína y analgésicos. La inyección de un parche hemático epidural es una opción válida cuando persisten los síntomas. La cirugía está indicada en casos refractarios o cuando existe un defecto anatómico evidente y accesible. En el presente artículo se describen tres casos clínicos con síndrome de hipotensión intracraneal secundarios a una fístula de líquido cefalorraquídeo espontánea a nivel espinal (AU)

Spontaneous intracranial hypotension syndrome (SIH) is a rare condition. The main symptom is orthostatic headache, although other symptoms such as vegetative symptoms, meningism, or focal neurological deficits may appear. The most common cause is a cerebrospinal fluid leak, usually traumatic. Spontaneous cerebrospinal fluid leaks are rare and associated with the presence of meningeal cysts / diverticula or in the setting of connective tissue diseases. The diagnosis is based on imaging tests, both to detect intracranial complications and bilateral subdural hematomas and to locate the leak point at the intracranial or spinal level. The treatment of SIH is usually conservative: bed rest, caffeine and analgesics. Epidural blood patch is a good option when symptoms persist. Surgery is indicated in refractory cases or when there is an evident and accessible anatomic defect. This article describes three clinical cases with intracranial hypotension syndrome secondary to a spontaneous spinal cerebrospinal fluid leak (AU)

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review.

BACKGROUND: Hemangioblastomas are vascular tumors, of benign behavior, that originate in the central nervous system. Supratentorial hemangioblastomas are extremely rare and are generally associated with Von Hippel-Lindau disease (VHL). The involvement of structures by contiguity, such as blood vessels or meninges, is something exceptional. There are few references in the literature of supratentorial hemangioblastomas with meningeal involvement and most of them are described in reports or small case series. METHODS: We performed a systematic review of the literature to observe the characteristics of patients with supratentorial hemangioblastomas with meningeal involvement. In addition, we present the case of a 43-year-old male patient with a sporadic supratentorial hemangioblastoma with both, meningeal and vascular involvement that recurred years after treatment. RESULTS: The patients presented supratentorial tumors with meningeal involvement, we had a 1.2:1 ratio male-female distribution. The mean age was 50 years. Most tumors were located in the cerebral hemispheres, the lobe affected most frequently was the frontal lobe. About 67% of the cases were sporadic and only 21% were related to VHL disease. There were three cases of recurrence after surgery. CONCLUSION: Supratentorial hemangioblastomas are extremely rare lesions. It is rare for supratentorial hemangioblastomas to invade adjacent structures such as blood vessels or meninges, however, when this happens, it is recommended a preoperative vascular imaging study, especially in parasagittal hemangioblastomas where superior longitudinal sinus may be involved. In these cases, en bloc surgical resection is difficult and the probability of recurrence is higher. Although clinical trials and studies with a greater casuistry are necessary to establish guidelines for the management of supratentorial hemangioblastomas, nowadays, contribution of new cases is useful for understanding this pathology.

Diagnosis of Glioblastoma by Immuno-Positron Emission Tomography.

Neuroimaging has transformed neuro-oncology and the way that glioblastoma is diagnosed and treated. Magnetic Resonance Imaging (MRI) is the most widely used non-invasive technique in the primary diagnosis of glioblastoma. Although MRI provides very powerful anatomical information, it has proven to be of limited value for diagnosing glioblastomas in some situations. The final diagnosis requires a brain biopsy that may not depict the high intratumoral heterogeneity present in this tumor type. The revolution in "cancer-omics" is transforming the molecular classification of gliomas. However, many of the clinically relevant alterations revealed by these studies have not yet been integrated into the clinical management of patients, in part due to the lack of non-invasive biomarker-based imaging tools. An innovative option for biomarker identification in vivo is termed "immunotargeted imaging". By merging the high target specificity of antibodies with the high spatial resolution, sensitivity, and quantitative capabilities of positron emission tomography (PET), "Immuno-PET" allows us to conduct the non-invasive diagnosis and monitoring of patients over time using antibody-based probes as an in vivo, integrated, quantifiable, 3D, full-body "immunohistochemistry" in patients. This review provides the state of the art of immuno-PET applications and future perspectives on this imaging approach for glioblastoma.

Intracranial hypotension secondary to spontaneous spinal cerebrospinal fluid fistula: Three case reports. / Hipotensión intracraneal secundaria a fístula espinal espontánea de líquido cefalorraquídeo: Presentación de tres casos.

Spontaneous intracranial hypotension syndrome (SIH) is a rare condition. The main symptom is orthostatic headache, although other symptoms such as vegetative symptoms, meningism, or focal neurological deficits may appear. The most common cause is a cerebrospinal fluid leak, usually traumatic. Spontaneous cerebrospinal fluid leaks are rare and associated with the presence of meningeal cysts / diverticula or in the setting of connective tissue diseases. The diagnosis is based on imaging tests, both to detect intracranial complications and bilateral subdural hematomas and to locate the leak point at the intracranial or spinal level. The treatment of SIH is usually conservative: bed rest, caffeine and analgesics. Epidural blood patch is a good option when symptoms persist. Surgery is indicated in refractory cases or when there is an evident and accessible anatomic defect. This article describes three clinical cases with intracranial hypotension syndrome secondary to a spontaneous spinal cerebrospinal fluid leak.

Glioblastoma with primitive neuronal component: A case report and considerations of fluorescence-guided surgery.

BACKGROUND: Glioblastoma with primitive neuronal components (GB/PNC) is an extremely rare type of glioblastoma characterized by presenting histological and cytogenetic features of both entities. The mixed nature of these tumors limits the imaging diagnosis and supposes a therapeutic dilemma. CASE DESCRIPTION: We present the case of a 77-year-old female with a GB/PNC who is treated with surgery and adjuvant radiochemotherapy according to the STUPP protocol, where an abnormal uptake of 5-aminolevulinic acid (5-ALA) is evident during surgery in probable relation to the mixed nature of GB/PNC. CONCLUSION: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope.

Factores relacionados con complicaciones posquirúrgicas en pacientes de edad avanzada con glioblastoma multiforme / Factors related with post-surgical complications in elderly patients with glioblastoma multiforme

Introducción. El glioblastoma multiforme es el tumor maligno más frecuente del sistema nervioso central, y su incidencia es del 80% en los mayores de 50 años. En los últimos tiempos se ha producido un aumento en la esperanza de vida de la población, y el análisis de las complicaciones posquirúrgicas en pacientes de edad avanzada resulta de gran relevancia para una correcta indicación quirúrgica. Objetivo. Analizar factores relacionados con las complicaciones posquirúrgicas en pacientes de edad avanzada. Pacientes y métodos. Se analizan retrospectivamente 88 pacientes diagnosticados de glioblastoma multiforme entre 31 y 78 años. Las variables estudiadas son: antecedentes personales, edad, estado funcional, estado preanestésico, características tumorales, tipo de cirugía y complicaciones posquirúrgicas. Resultados. Se observa una influencia de la edad en las complicaciones quirúrgicas locales (p = 0,006) y sistémicas (p = 0,034) y en la escala de Clavien-Dindo (p = 0,001). Las personas con peor estado funcional y riesgo cardiovascular presentaron más complicaciones sistémicas (p = 0,006 y 0,044) y peor graduación en dicha escala (p = 0,024 y 0,025). Asimismo, hallamos más complicaciones locales en las cirugías de exéresis que en las biopsias (p = 0,027). El estado preanestésico y los tratamientos antihemostáticos no se relacionaron con dichos eventos. Conclusiones. Los pacientes mayores de 65 años presentan una mayor incidencia de antecedentes patológicos y peor estado funcional prequirúrgico. La edad, el riesgo cardiovascular, el estado funcional y el tipo de cirugía han aumentado de manera significativa las complicaciones posquirúrgicas (AU)

Introduction. Glioblastoma multiforme is the most frequent malignant tumour of the central nervous system, and its incidence reaches 80% in those over 50 years of age. Life expectancy has increased in the population in recent times and an analysis of the post-surgical complications affecting elderly patients is of great importance for a correct surgical indication. Aims. To analyse the factors related with post-surgical complications in elderly patients. Patients and methods. A sample of 88 patients diagnosed with glioblastoma multiforme between 31 and 78 years of age was analysed retrospectively. The variables taken into consideration in the study were: personal medical history, age, functional status, pre-anaesthetic status, tumour characteristics, type of surgery and post-surgical complications. Results. Age was observed to have an influence on local (p = 0.006) and systemic surgical complications (p = 0.034), and on the Clavien-Dindo scale (p = 0.001). Persons with a poorer functional status and cardiovascular risk presented more systemic complications (p = 0.006 and 0.044) and a lower score on the Clavien-Dindo scale (p = 0.024 and 0.025) respectively. Likewise, more local complications are found in the case of excisional procedures than in biopsies (p = 0.027). The pre-anaesthetic status and anti-haemostatic treatments were not related with such events. Conclusions. Patients over 65 years of age present a higher incidence of pathological antecedents and a poorer presurgical functional status. Age, cardiovascular risk, functional status and the type of surgical procedure have significantly increased the occurrence of post-surgical complications (AU)

La biopsia cerebral no es una cirugía menor / Brain biopsy is not minor surgery

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