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1.
JDR Clin Trans Res ; 9(1): 95-97, 2024 Jan.
Article in English | MEDLINE | ID: mdl-36691344

ABSTRACT

KNOWLEDGE TRANSFER STATEMENT: The challenges and recommendations outlined in this commentary will serve as steppingstones to process the concepts of translational science, facilitate training for future scientists, and serve as an approach for the early investigators in the field of translational science.


Subject(s)
Translational Research, Biomedical , Translational Science, Biomedical , Humans , Translational Research, Biomedical/education , Research Personnel/education , Forecasting , Knowledge
2.
Microsc Microanal ; 29(Supplement_1): 1796-1797, 2023 Jul 22.
Article in English | MEDLINE | ID: mdl-37613984
3.
J Bone Joint Surg Am ; 105(Suppl 1): 87-96, 2023 07 19.
Article in English | MEDLINE | ID: mdl-37466585

ABSTRACT

BACKGROUND: Surgical site infection (SSI) after segmental endoprosthetic reconstruction in patients treated for oncologic conditions remains both a devastating and a common complication. The goal of the present study was to identify variables associated with the success or failure of treatment of early SSI following the treatment of a primary bone tumor with use of a segmental endoprosthesis. METHODS: The present study used the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) data set to identify patients who had been diagnosed with an SSI after undergoing endoprosthetic reconstruction of a lower extremity primary bone tumor. The primary outcome of interest in the present study was a dichotomous variable: the success or failure of infection treatment. We defined failure as the inability to eradicate the infection, which we considered as an outcome of amputation or limb retention with chronic antibiotic suppression (>90 days or ongoing therapy at the conclusion of the study). Multivariable models were created with covariates of interest for each of the following: surgery characteristics, cancer treatment-related characteristics, and tumor characteristics. Multivariable testing included variables selected on the basis of known associations with infection or results of the univariable tests. RESULTS: Of the 96 patients who were diagnosed with an SSI, 27 (28%) had successful eradication of the infection and 69 had treatment failure. Baseline and index procedure variables showing significant association with SSI treatment outcome were moderate/large amounts of fascial excision ≥1 cm2) (OR, 10.21 [95% CI, 2.65 to 46.21]; p = 0.001), use of local muscle/skin graft (OR,11.88 [95% CI, 1.83 to 245.83]; p = 0.031), and use of a deep Hemovac (OR, 0.24 [95% CI, 0.05 to 0.85]; p = 0.041). In the final multivariable model, excision of fascia during primary tumor resection was the only variable with a significant association with treatment outcome (OR, 10.21 [95% CI, 2.65 to 46.21]; p = 0.018). CONCLUSIONS: The results of this secondary analysis of the PARITY trial data provide further insight into the patient-, disease-, and treatment-specific associations with SSI treatment outcomes, which may help to inform decision-making and management of SSI in patients who have undergone segmental bone reconstruction of the femur or tibia for oncologic indications. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.


Subject(s)
Bone Neoplasms , Surgical Wound Infection , Humans , Anti-Bacterial Agents/therapeutic use , Bone Neoplasms/pathology , Prostheses and Implants/adverse effects , Retrospective Studies , Risk Factors , Surgical Wound Infection/etiology , Surgical Wound Infection/prevention & control , Tibia/surgery
4.
Phys Rev Lett ; 129(1): 012502, 2022 Jul 01.
Article in English | MEDLINE | ID: mdl-35841540

ABSTRACT

A near-threshold proton resonance in ^{11}B at E_{ex}=11.44±0.04 MeV is observed via the reaction ^{10}Be(d,n)^{11}Be→^{10}Be+p in inverse kinematics, measured with a beam of the radioactive isotope ^{10}Be. The resonance energy at E_{res}=211(40) keV is consistent with a proton signal observed by Ayyad et al. in the ß-delayed proton decay of ^{11}Be. By comparison to a distorted wave Born approximation calculation, a 0.27(6) spectroscopic factor is extracted and a tentative (ℓ=0) character is assigned for this resonance. The significant cross section in the proton-transfer (d,n) reaction, as well as the observation of its proton-decay signal, point to the threshold-resonance character of this state. The position of this state, its structure, and strong coupling to the s-wave continuum represent an ideal case to study quantum near-threshold many-body dynamics of unstable states. The presence of this state is an important step toward understanding the excessively large beta-delayed proton-decay branch of ^{11}Be.

5.
Prensa méd. argent ; 107(4): 204-218, 20210000. fig, graf, tab
Article in English | LILACS, BINACIS | ID: biblio-1359441

ABSTRACT

Los biorreactores de sistemas de un solo uso (SUSs), también conocidos como biorreactores desechables, se han convertido en una parte integral de las instalaciones biotecnológicas de fabricación para bioproductos con un mercado potencial que espera una tasa de crecimiento de casi el 15,5% durante el período pronosticado: 2018 a 2023. Los biorreactores SUSs son más seguros, simples y flexibles al compararlos con sus contrapartes, biorreactores de acero inoxidable, por lo que su uso se está incrementando en la industria biofarmacéutica principalmente en la planificación de vías rápidas de proyectos complejos, incluidos los relacionados con la pandemia de SARS-CoV-2. Así, el uso de SUS se ha convertido en una alternativa eficaz para la producción rápida de candidatos a vacunas. Pero algunas desventajas técnicas y operativas aún obstaculizan su uso en todo el mundo. Esta revisión brinda una visión racional del uso, los tipos, los parámetros operativos y las nuevas aplicaciones de los biorreactores SUSs en la industria biofarmacéutica. Asimismo, también se discuten los parámetros apropiados y las limitaciones de este equipo, enfocándose en su uso para la producción de vacunas contra COVID-19


Single-Use-Systems (SUSs) Bioreactors, also known as disposable bioreactors, have become an integral part of biotechnology manufacturing facilities for bioproducts with a potential market expecting a growth rate of nearly 15.5% over the forecast period: 2018 to 2023. SUSs bioreactors are comparatively safe, simple, and flexible than their stainless-steel bioreactors counterparts thus, their usage is being augmented in the biopharmaceutical industry mainly in planning fast tracks of complex projects, including those related to the SARS-CoV-2 pandemic. Thus, the use of SUSs has become an effective alternative for the rapid production of vaccine candidates. However, some technical and operational disadvantages still hamper their worldwide use. This review gives a rational insight into SUSs bioreactors use, types, operational parameters and new applications in the biopharmaceutical industry. Likewise, the appropriate parameters and limitations of this equipment, focusing on its use for vaccine production against COVID-19 are also discussed


Subject(s)
Humans , Biopharmaceutics , Biotechnology , Bioreactors , Industrial Development , Manufacturing and Industrial Facilities , COVID-19 Vaccines/supply & distribution
6.
Acta Oncol ; 60(6): 714-720, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33630699

ABSTRACT

BACKGROUND: The clinical relevance of patient-reported outcomes score changes is often unclear. Especially in patients undergoing surgery due to lower extremity metastases - where surgery is performed in the palliative setting and the goal is to optimize functional mobility, relieve pain and improve overall quality of life. This study assessed the minimal clinically important difference (MCID) of Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference, Cancer-specific Physical Function, and Global (Physical and Mental Health) in patients treated surgically for impending or completed pathologic fractures. METHODS: Patients undergoing surgery for osseous metastasis of the lower extremity because of an impending or completed pathologic fracture were consecutively enrolled in this tertiary center study. Patients completed the three PROMIS questionnaires preoperatively (n = 56) and at postoperative follow-up (n = 33) assessment one to three months later. Of the 23 patients that did not complete the postoperative survey, 5 patients died within 1-3 months and 18 patients were alive at 3-months but did not respond or show up at their postoperative consult. Thirty-one patients (94%) of the 33 included patients reported at least minimal improvement and two patients (6.1%) no change 1-3 months after the surgery based on an anchor-based approach. RESULTS: The PROMIS MCIDs (95% confidence interval) for Pain Interference was 7.5 (3.4-12), Physical Function 4.1 (0.6-7.6), Global Physical Health 4.2 (2.0-6.6), and Global Mental Health 0.8 (-4.5-2.9). CONCLUSION: This prospective study successfully defined a MCID for PROMIS Pain Interference of 7.5 (3.4-12), PROMIS Physical Function of 4.1 (0.6-7.6), and Global Physical Health of 4.2 (2.0-6.6) in patients with (impending) pathological fractures due to osseous metastases in the lower extremity; no MCID could be established for PROMIS Global Mental Health. Defining a narrower MCID value for each subpopulation requires a large, prospective, multicenter study. Nevertheless, the provided MCID values allow guidance to clinicians to evaluate the impact of surgical treatment on a patient's QoL. LEVEL OF EVIDENCE: Level II Diagnostic study.


Subject(s)
Lower Extremity , Minimal Clinically Important Difference , Neoplasm Metastasis , Quality of Life , Humans , Lower Extremity/surgery , Patient Reported Outcome Measures , Prospective Studies , Tertiary Care Centers
7.
Public Health ; 189: 81-90, 2020 Dec.
Article in English | MEDLINE | ID: mdl-33188998

ABSTRACT

OBJECTIVES: The study was conducted to assess time trend shifts of leading causes of death and their partial contributions over the years 1975-2016 in Spain. STUDY DESIGN: A longitudinal ecological epidemiologic design was conducted to analyse linear trend period shifts using joinpoint regression as the annual percentage of change (APC) in the period 1975-2016. The partial contributions were illustrated as the rate ratio of a singular-cause to their major-cause shift periods. RESULTS: HIV/AIDS shaped the increasing trend period of infectious diseases in 1989-1995 (APC = 25.3, P < 0.05) and the decreasing trend in 1995-1999 and 1999-2016. Lung cancer fell gradually from 1994 in men (-0.4, P < 0.05); however, in women, the condition continued increasing from 1990 (P < 0.05). Dementia types influenced mental and neurological disease drifts. The recent trend for circulatory periods (1980-2016) was mainly modulated by cardiac ischaemia, with increased partial contributions (25%, 32% and 30%). Traffic accidents defined the descending tendency of external causes. CONCLUSIONS: Spain showed a Western pattern in descended rates, including non-decreasing trends in mental and neurological diseases, pancreatic cancer, drug abuse and suicide. Trend shifts and partial contributions illustrated targets for further mortality reduction.


Subject(s)
Cause of Death/trends , Accidents, Traffic/mortality , Acquired Immunodeficiency Syndrome/mortality , Adult , Aged , Causality , Dementia/mortality , Female , Humans , Longitudinal Studies , Lung Neoplasms/mortality , Male , Middle Aged , Mortality/trends , Myocardial Ischemia/mortality , Pancreatic Neoplasms/mortality , Spain , Suicide/statistics & numerical data
8.
Rev. clín. esp. (Ed. impr.) ; 219(9): 469-476, dic. 2019. tab, graf
Article in Spanish | IBECS | ID: ibc-193145

ABSTRACT

ANTECEDENTES Y OBJETIVOS: Describir las características clínicas y el pronóstico-mortalidad intrahospitalaria, a 30 días y a 12 meses y reconsulta en urgencias a 30 días por insuficiencia cardiaca aguda- de pacientes atendidos en servicios de urgencias hospitalarios por insuficiencia cardiaca aguda de nueva aparición o de novo (ICAN) y compararlas con los que consultan por insuficiencia cardiaca crónica descompensada (ICAD). PACIENTES: NOVICA es un análisis secundario del registro Epidemiology of Acute Heart Failure in Emergency Departments. Se compararon variables demográficas, características basales, datos del episodio agudo y seguimiento a 30 días y al año de pacientes con ICAN e ICAD. RESULTADOS: Se analizaron 8647 pacientes, 3288 ICAN (38%) y 5359 ICAD (62%). Las ICAN asociaron menor comorbilidad, mejor estado basal, datos de menor gravedad del episodio agudo: menor uso de diuréticos en perfusión intravenosa y de oxigenoterapia, menor tasa de hospitalización. Las ICAN ingresaron más frecuentemente en cardiología o unidades de cuidados intensivos y las ICAD en unidades de corta estancia. La mortalidad cruda a 30 días y a 12 meses y la reconsulta a 30 días fueron inferiores en pacientes con ICAN. No obstante, en el análisis ajustado solo la reconsulta a 30 días fue inferior en las ICAN (p < 0,001). CONCLUSIONES: Los pacientes que consultan en servicios de urgencias hospitalarios por ICAN muestran un perfil clínico diferente a los pacientes con ICAD. En los análisis ajustados, no hay diferencias entre los dos grupos en relación a mortalidad intrahospitalaria, a 30 días ni a 12 meses


BACKGROUND AND OBJECTIVES: To describe the clinical characteristics and prognosis (hospital mortality at 30 days and 12 months and emergency department readmission at 30 days for acute heart failure) of patients treated in hospital emergency departments for new-onset or de novo acute heart failure (NOAHF) and to compare the patients with those who consult for chronic decompensated heart failure (CDHF). PATIENTS: NOVICA is a secondary analysis of the Epidemiology of Acute Heart Failure in Emergency Departments registry. We compared demographic variables, baseline characteristics and data from acute episodes and follow-up at 30 days and 12 months of patients with NOAHF and CDHF. RESULTS: We analysed 8647 patients, with 3288 cases of NOAHF (38%) and 5359 cases of CDHF (62%). NOAHF was associated with lower comorbidity, better baseline state, less severe acute episode data, less use of diuretics in intravenous infusion and oxygen therapy and lower hospitalization rates. The patients with NOAHF were admitted more often to cardiology and intensive care units, and the patients with CDHF were admitted more often to short-stay units. Rates of crude mortality at 30 days and 12 months and readmission at 30 days were higher for the patients with NOAHF. In the adjusted analysis, however, only the rate of readmission at 30 days was lower for NOAHF (p<.001). CONCLUSIONS: Patients admitted to hospital emergency departments for NOAHF show a different clinical profile from patients with CDHF. In the adjusted analysis, there were no differences between the 2 groups regarding hospital mortality, 30-day mortality or 12-month mortality


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Heart Failure/diagnosis , Heart Failure/epidemiology , Referral and Consultation , Prognosis , Hospital Mortality , Acute Disease , Comorbidity , Survival Analysis
9.
Rev Clin Esp (Barc) ; 219(9): 469-476, 2019 Dec.
Article in English, Spanish | MEDLINE | ID: mdl-31253436

ABSTRACT

BACKGROUND AND OBJECTIVES: To describe the clinical characteristics and prognosis (hospital mortality at 30 days and 12 months and emergency department readmission at 30 days for acute heart failure) of patients treated in hospital emergency departments for new-onset or de novo acute heart failure (NOAHF) and to compare the patients with those who consult for chronic decompensated heart failure (CDHF). PATIENTS: NOVICA is a secondary analysis of the Epidemiology of Acute Heart Failure in Emergency Departments registry. We compared demographic variables, baseline characteristics and data from acute episodes and follow-up at 30 days and 12 months of patients with NOAHF and CDHF. RESULTS: We analysed 8647 patients, with 3288 cases of NOAHF (38%) and 5359 cases of CDHF (62%). NOAHF was associated with lower comorbidity, better baseline state, less severe acute episode data, less use of diuretics in intravenous infusion and oxygen therapy and lower hospitalization rates. The patients with NOAHF were admitted more often to cardiology and intensive care units, and the patients with CDHF were admitted more often to short-stay units. Rates of crude mortality at 30 days and 12 months and readmission at 30 days were higher for the patients with NOAHF. In the adjusted analysis, however, only the rate of readmission at 30 days was lower for NOAHF (p<.001). CONCLUSIONS: Patients admitted to hospital emergency departments for NOAHF show a different clinical profile from patients with CDHF. In the adjusted analysis, there were no differences between the 2 groups regarding hospital mortality, 30-day mortality or 12-month mortality.

11.
Surg Oncol ; 28: 135-139, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30851887

ABSTRACT

BACKGROUND AND OBJECTIVES: The value of gadolinium enhanced magnetic resonance imaging (MRI) sequences for extremity osteosarcoma resection planning is unverified. We evaluate the performance of intravenous gadolinium enhanced MRI for identification of neurovascular bundle involvement (NBI) and intraarticular extension (IAE) in patients with osteosarcoma. METHODS: Two pediatric radiologists independently analyzed MRI examinations of patients with pathology proven extremity osteosarcoma for NBI and IAE. Initial evaluation utilized only non-contrast MRI images (PRE) and, after 2 weeks, subsequent evaluation included both the pre and post contrast images (POST). Cohen's Kappa and McNemar's test were calculated to assess agreement between PRE and POST image interpretations of NBI and IAE. RESULTS: 56 patients with 90 preoperative MRI examinations were analyzed. PRE and POST interpretations were rarely discordant; 4/90 cases for NBI (Kappa 0.91) and 2/90 cases for IAE (Kappa 0.95). McNemar's test did not show a difference between PRE and POST imaging (NBI p=0.62; IAE p=0.48). CONCLUSION: No significant difference between PRE and POST image interpretation was found. A high level of agreement between PRE and POST image interpretation suggests that pre-contrast MRI may be sufficient for pre-surgical planning for pediatric patients with long bone osteosarcoma.


Subject(s)
Bone Neoplasms/pathology , Bone and Bones/pathology , Contrast Media , Magnetic Resonance Imaging/methods , Observer Variation , Osteosarcoma/pathology , Preoperative Care , Adolescent , Adult , Bone Neoplasms/surgery , Bone and Bones/surgery , Child , Female , Follow-Up Studies , Gadolinium , Humans , Male , Osteosarcoma/surgery , Prognosis , Retrospective Studies , Young Adult
12.
SEMERGEN, Soc. Esp. Med. Rural Gen. (Ed. Impr.) ; 45(1): 23-29, ene.-feb. 2019. tab
Article in Spanish | IBECS | ID: ibc-188044

ABSTRACT

OBJETIVOS: 1) Conocer la prevalencia de violencia de pareja (VP) en las pacientes que consultan a urgencias por dolor torácico. 2)Analizar la posible asociación entre VP y presencia/control de factores de riesgo vascular (FRV), manifestaciones psíquicas de estrés, demora en la solicitud de atención, manejo del episodio y pronóstico. MÉTODOS: Se incluyó a 125 mujeres. Se realizó entrevista dirigida, test del Partner Violence Screen (PVS), seguimiento telefónico a los 30 días y revisión del historial clínico al año. RESULTADOS: Veintisiete pacientes (21,6%) tenían historia de VP, que era vigente en 4 de ellas. Las mujeres que habían sufrido VP eran más jóvenes (53,7 ± 15,0 vs 64,0 ± 18,4; p = 0,020), presentaban más frecuentemente síndrome ansioso-depresivo (57,7% vs 13,5%; p < 0,001) y tardaron más en consultar (35,0 ± 65,2 días vs 7,9 ± 25,0días; p = 0,047). Entre las mujeres mayores (≥ 65 años) existía más dislipidemia (100% vs 60,4%; p = 0,039) y peor control de la presión arterial (buen control 20% vs 78,4%; p = 0,007) en las que tenían historia de VP. No hubo diferencias en los diagnósticos, pruebas, tiempo de estancia, ingresos o evolución entre las pacientes con historia de VP o sin ella, ni hubo diferencias según la vigencia de la VP. CONCLUSIONES: La existencia actual o previa de VP en las pacientes que consultan por dolor torácico en urgencias es elevada. La existencia de VP va asociada a un retraso en la consulta y a mayor ansiedad, y puede contribuir a un mal control de los FRV, pero no afecta la evolución a medio plazo


OBJECTIVES: 1) To determine the prevalence of intimate partner violence (IPV) in patients seen in the emergency department with chest pain. 2) To analyse the possible association between IPV and presence/control of vascular risk factors (VRF), psychic manifestations of stress, delay in requesting care, care received, and prognosis. METHODS: The study was conducted on 125 women, and included a targeted interview, the Partner Violence Screen (PVS) test, a 30-day follow-up telephone interview, and a one-year follow-up clinical history review. RESULTS: A total of 27 patients (21.6%) had a history of IPV, which was present in 4 of them. Women with a history of IPV were younger (53.7 ± 15.0 vs. 64.0 ± 18.4; P = .020), had more anxiety or a depressive syndrome (57.7% vs 13.5%; P < 0.001), and consulted later (35.0 ± 65.2days vs 7.9 ± 25.0days; P = .047). Among older women ( ≥ 65years), there was more dyslipidaemia (100% vs 60.4%; P = .039) and worse blood pressure control (good control 20% vs 78.4%; P = .007) in those with a history of IPV. There were no differences in the diagnoses, tests, length of stay, admissions or prognosis among patients with or without a history of IPV, and there were no differences according to chronology of IPV. CONCLUSIONS: The current or previous existence of IPV in patients who consult for chest pain in the emergency department is high. The existence of IPV is associated with a delay in consultation and greater anxiety, and may contribute to poor control of VRF, but does not affect the prognosis in the medium term


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Emergency Service, Hospital/statistics & numerical data , Intimate Partner Violence/statistics & numerical data , Chest Pain/epidemiology , Mass Screening/methods , Follow-Up Studies , Interviews as Topic , Length of Stay , Patient Acceptance of Health Care/statistics & numerical data , Prevalence , Prognosis , Risk Factors , Sexual Partners , Time Factors , Age Factors , Prospective Studies , Socioeconomic Factors
13.
Semergen ; 45(1): 23-29, 2019.
Article in Spanish | MEDLINE | ID: mdl-30268361

ABSTRACT

OBJECTIVES: 1) To determine the prevalence of intimate partner violence (IPV) in patients seen in the emergency department with chest pain. 2)To analyse the possible association between IPV and presence/control of vascular risk factors (VRF), psychic manifestations of stress, delay in requesting care, care received, and prognosis. METHODS: The study was conducted on 125 women, and included a targeted interview, the Partner Violence Screen (PVS) test, a 30-day follow-up telephone interview, and a one-year follow-up clinical history review. RESULTS: A total of 27 patients (21.6%) had a history of IPV, which was present in 4 of them. Women with a history of IPV were younger (53.7±15.0 vs. 64.0±18.4; P=.020), had more anxiety or a depressive syndrome (57.7% vs 13.5%; P<0.001), and consulted later (35.0±65.2days vs 7.9±25.0days; P=.047). Among older women (≥65years), there was more dyslipidaemia (100% vs 60.4%; P=.039) and worse blood pressure control (good control 20% vs 78.4%; P=.007) in those with a history of IPV. There were no differences in the diagnoses, tests, length of stay, admissions or prognosis among patients with or without a history of IPV, and there were no differences according to chronology of IPV. CONCLUSIONS: The current or previous existence of IPV in patients who consult for chest pain in the emergency department is high. The existence of IPV is associated with a delay in consultation and greater anxiety, and may contribute to poor control of VRF, but does not affect the prognosis in the medium term.


Subject(s)
Chest Pain/epidemiology , Emergency Service, Hospital/statistics & numerical data , Intimate Partner Violence/statistics & numerical data , Mass Screening/methods , Adult , Age Factors , Aged , Female , Follow-Up Studies , Humans , Interviews as Topic , Length of Stay , Middle Aged , Patient Acceptance of Health Care/statistics & numerical data , Prevalence , Prognosis , Risk Factors , Sexual Partners , Time Factors
14.
Phys Rev Lett ; 121(11): 112701, 2018 Sep 14.
Article in English | MEDLINE | ID: mdl-30265109

ABSTRACT

The ^{36}Ar(n,γ)^{37}Ar (t_{1/2}=35 d) and ^{38}Ar(n,γ)^{39}Ar (269 yr) reactions were studied for the first time with a quasi-Maxwellian (kT∼47 keV) neutron flux for Maxwellian average cross section (MACS) measurements at stellar energies. Gas samples were irradiated at the high-intensity Soreq applied research accelerator facility-liquid-lithium target neutron source and the ^{37}Ar/^{36}Ar and ^{39}Ar/^{38}Ar ratios in the activated samples were determined by accelerator mass spectrometry at the ATLAS facility (Argonne National Laboratory). The ^{37}Ar activity was also measured by low-level counting at the University of Bern. Experimental MACS of ^{36}Ar and ^{38}Ar, corrected to the standard 30 keV thermal energy, are 1.9(3) and 1.3(2) mb, respectively, differing from the theoretical and evaluated values published to date by up to an order of magnitude. The neutron-capture cross sections of ^{36,38}Ar are relevant to the stellar nucleosynthesis of light neutron-rich nuclides; the two experimental values are shown to affect the calculated mass fraction of nuclides in the region A=36-48 during the weak s process. The new production cross sections have implications also for the use of ^{37}Ar and ^{39}Ar as environmental tracers in the atmosphere and hydrosphere.

15.
Acta Ortop Mex ; 31(3): 134-140, 2017.
Article in Spanish | MEDLINE | ID: mdl-29216704

ABSTRACT

BACKGROUND: Femoroacetabular impingement (FAI) is a suggested diagnosis for pain in the hip in the absence of other apparent causes. It is thought to be a cause of progressive arthrosis of the hip. Our objective was to determine the prevalence of radiographic data of FAI in the adult population without hip pathology over a period of six months. MATERIAL AND METHODS: Analytical, observational, multicentric, ambispective and transverse study based on digital X-rays analysis. Measurements of the lateral center-edge angle of Wiberg, acetabular inclination, Tönnis angle and the neck shaft angle of the proximal femur were made; a pistol grip deformity of the femoral head, the triangular index and the shape of the coxofemoral joint were also evaluated. RESULTS: From a total of 212 hips evaluated, 104 were in males and 108 in females, with an average age of 42.81 years; 21 had a pistol grip deformity and a positive triangular index for cam type. The pincer type was found in 12 hips. DISCUSSION: In this multicentric study, the FAI cam type predominated in men on the right side; the pincer type predominated in women on the left side; this is similar to what has been reported in other populations. This study is limited by the wide variation in the femoral rotation; as an advantage, it was randomly carried out and provides some data on the prevalence of deformities of the hip, not previously registered.


INTRODUCCIÓN: El pinzamiento femoroacetabular (PFA) se considera actualmente la causa principal de osteoartritis idiopática o primaria de cadera. Nuestro objetivo fue determinar la prevalencia de datos radiográficos de PFA en la población adulta sin patología coxofemoral en un período de seis meses. MATERIAL Y MÉTODOS: Estudio analítico, observacional, multicéntrico, ambispectivo y transversal realizado en archivos radiográficos digitales. Se midieron los ángulos de cobertura acetabular, cervicodiafisario, inclinación acetabular y ángulo de Tönnis; el tipo de coxa, índice triangular y deformidad en mango de pistola. RESULTADOS: De 212 articulaciones coxofemorales, 49.1% (104/212) correspondieron a hombres y 50.9% (108/212) a mujeres, con edad promedio de 42.81 ± 17.9 años; 21 articulaciones (21/212, 9.9%) presentaron deformidad en mango de pistola más índice triangular positivo para cam. Para determinar el tipo pincer, correlacionamos sobrecobertura acetabular, horizontalización acetabular, ángulo de Tönnis negativo ( 0°) y tipo de coxa profunda y/o protrusio, con una prevalencia de 5.66% de pincer (12/212). DISCUSIÓN: Nuestra población es muy pequeña a pesar de involucrar varias instituciones; la prevalencia del PFA tipo cam predominó en hombres, del lado derecho. El tipo pincer predominó en mujeres, del lado izquierdo. Este estudio está limitado por la amplia variación radiológica de la rotación femoral. Por otro lado, se aportan algunos datos sobre la prevalencia de deformidades de la cadera, previamente no registrada.


Subject(s)
Femoracetabular Impingement , Acetabulum , Adult , Female , Femoracetabular Impingement/diagnostic imaging , Femoracetabular Impingement/epidemiology , Hip Joint , Humans , Male , Prevalence , X-Rays
16.
Phys Rev Lett ; 119(7): 072701, 2017 Aug 18.
Article in English | MEDLINE | ID: mdl-28949677

ABSTRACT

The existence of ^{26}Al (t_{1/2}=7.17×10^{5} yr) in the interstellar medium provides a direct confirmation of ongoing nucleosynthesis in the Galaxy. The presence of a low-lying 0^{+} isomer (^{26}Al^{m}), however, severely complicates the astrophysical calculations. We present for the first time a study of the ^{26}Al^{m}(d,p)^{27}Al reaction using an isomeric ^{26}Al beam. The selectivity of this reaction allowed the study of ℓ=0 transfers to T=1/2, and T=3/2 states in ^{27}Al. Mirror symmetry arguments were then used to constrain the ^{26}Al^{m}(p,γ)^{27}Si reaction rate and provide an experimentally determined upper limit of the rate for the destruction of isomeric ^{26}Al via radiative proton capture reactions, which is expected to dominate the destruction path of ^{26}Al^{m} in asymptotic giant branch stars, classical novae, and core collapse supernovae.

17.
J Chem Phys ; 144(4): 044706, 2016 Jan 28.
Article in English | MEDLINE | ID: mdl-26827227

ABSTRACT

The oxidation of CO on Pt(111) was investigated simultaneously by near ambient pressure X-ray photoelectron spectroscopy and online gas analysis. Different CO:O2 reaction mixtures at total pressures of up to 1 mbar were used in continuous flow mode to obtain an understanding of the surface chemistry. By temperature-programmed and by isothermal measurements, the onset temperature of the reaction was determined for the different reactant mixtures. Highest turnover frequencies were found for the stoichiometric mixture. At elevated temperatures, the reaction becomes diffusion-limited in both temperature-programmed and isothermal measurements. In the highly active regime, no adsorbates were detected on the surface; it is therefore concluded that the catalyst surface is in a metallic state, within the detection limits of the experiment, under the applied conditions. Minor bulk impurities such as silicon were observed to influence the reaction up to total inhibition by formation of non-platinum oxides.

18.
Sci Total Environ ; 542(Pt A): 93-101, 2016 Jan 15.
Article in English | MEDLINE | ID: mdl-26519570

ABSTRACT

It has been recognized that numerous synthetic compounds like Bisphenol A (BPA) and nonylphenols (NP) are present in effluents from wastewater treatment plants (WWTP) at levels of parts per billion (µg L(-1)) or even parts per trillion (ng L(-1)) with a high potential to cause endocrine disruption in the aquatic environment. Constructed wetlands (CW) are a cost-effective wastewater treatment alternative with promising performance to treat these afore mentioned compounds. This research was aimed to evaluate the efficacy of CW treatment of WWTP effluent for mitigating the effects endocrine disrupting compounds (EDCs). This research goal was accomplished by (1) quantifying the removal of BPA and NP in CWs; (2) isolating CW fungal strains and testing for laccase production; and (3) performing endocrine disruption (reproduction) bioassays using the fruit fly Drosophila melanogaster. Three pilot scale horizontal subsurface flow constructed wetlands (HSSF-CW) were operated for eight weeks: one planted with Phragmites australis; one planted with Heliconia psitacorum; and one unplanted. The Heliconia CW showed a removal efficiency of 73.3(± 19%) and 62.8(± 20.1%) for BPA and NP, respectively; while the Phragmites CW demonstrated a similar removal for BPA (70.2 ± 27%) and lower removal efficiency for NP 52.1(± 37.1%).The unplanted CW achieved 62.2 (± 33%) removal for BPA and 25.3(± 37%) removal for NP. Four of the eleven fungal strains isolated from the Heliconia-CW showed the capacity to produce laccase. Even though complete removal of EDCs was not achieved by the CWs, the bioassay confirmed a significant improvement (p < 0.05) in fly viability for all CWs, with Heliconia sp. being the most effective at mitigating adverse effects on first and second generational reproduction. This study showed that a CW planted with a native Heliconia sp. CW demonstrated a higher removal of endocrine disrupting compounds and better mitigation of reproductive disruption in the bioassay.


Subject(s)
Benzhydryl Compounds/analysis , Phenols/analysis , Waste Disposal, Fluid/methods , Wastewater/chemistry , Water Pollutants, Chemical/analysis , Wetlands
20.
Phys Rev Lett ; 114(25): 251102, 2015 Jun 26.
Article in English | MEDLINE | ID: mdl-26197115

ABSTRACT

Neutrons produced by the carbon fusion reaction (12)C((12)C,n)(23)Mg play an important role in stellar nucleosynthesis. However, past studies have shown large discrepancies between experimental data and theory, leading to an uncertain cross section extrapolation at astrophysical energies. We present the first direct measurement that extends deep into the astrophysical energy range along with a new and improved extrapolation technique based on experimental data from the mirror reaction (12)C((12)C,p)(23)Na. The new reaction rate has been determined with a well-defined uncertainty that exceeds the precision required by astrophysics models. Using our constrained rate, we find that (12)C((12)C,n)(23)Mg is crucial to the production of Na and Al in pop-III pair instability supernovae. It also plays a nonnegligible role in the production of weak s-process elements, as well as in the production of the important galactic γ-ray emitter (60)Fe.

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