ABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Adenocarcinoma of Lung/drug therapy , Lung Neoplasms/drug therapy , Antineoplastic Agents, Immunological/adverse effects , Enterocolitis/chemically induced , Enterocolitis/drug therapy , Infliximab/therapeutic use , Gastrointestinal Agents/therapeutic use , Ipilimumab/adverse effects , Nivolumab/adverse effects , Adenocarcinoma of Lung/complications , Lung Neoplasms/complications , Tomography, X-Ray ComputedABSTRACT
No disponible
Subject(s)
Humans , Adult , Crohn Disease/complications , Cystic Fibrosis/complications , Risk Factors , Gastroesophageal Reflux/complications , Diagnosis, DifferentialABSTRACT
La distinción de la enfermedad relacionada con IgG4 como una entidad inmunomediada que engloba patologías consideradas clásicamente como idiopáticas ha supuesto una revolución en el algoritmo diagnóstico y terapéutico en diferentes especialidades médicas. Esta entidad suele implicar a diversos órganos (la afectación de un órgano aislado, a excepción del páncreas, es infrecuente), lo cual determina unos hallazgos histopatológicos característicos. Presentamos el caso de un paciente valorado por dolor abdominal que, tras estudio exhaustivo y habiendo descartado otras etiologías, fue diagnosticado de mesenteritis esclerosante IgG4 cumpliendo criterios radiológicos e histopatológicos (AU)
The identification of IgG4-related disease as a distinct immune-mediated condition encompassing disorders that were traditionally seen as idiopathic has been a revolution in the diagnostic and therapeutic algorithm in several medical fields. This condition usually involves multiple organs (isolated organ involvement is uncommon except in the pancreas) with characteristic histopathological findings. We report a case that was assessed due to abdominal pain and subsequently diagnosed with IgG4-related sclerosing mesenteritis. A comprehensive work-up of the case ruled out other conditions and a diagnosis of IgG4-related sclerosing mesenteritis was made according to radiographic and histopathological criteria (AU)
Subject(s)
Humans , Male , Adult , Mesentery/physiopathology , Hypergammaglobulinemia/complications , Adrenal Cortex Hormones/therapeutic use , Abdominal Pain/etiology , Inflammation/physiopathology , Fibrosis/physiopathologyABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Immunosuppressive Agents/therapeutic use , Crohn Disease/drug therapy , Common Variable Immunodeficiency/drug therapy , Treatment Outcome , Diarrhea/etiologyABSTRACT
No disponible
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Listeriosis/diagnosis , Listeria monocytogenes/pathogenicity , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Irritable Bowel Syndrome/drug therapy , Disease Susceptibility/chemically induced , Immunosuppressive Agents/adverse effectsABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Anemia, Hemolytic, Autoimmune/drug therapy , Antibodies, Monoclonal/pharmacokinetics , Colitis, Ulcerative/complications , Inflammatory Bowel Diseases/drug therapySubject(s)
Humans , Male , Middle Aged , Anal Gland Neoplasms/complications , Anal Gland Neoplasms/diagnosis , Adenocarcinoma/complications , Adenocarcinoma , Crohn Disease/complications , Crohn Disease/diagnosis , Anal Gland Neoplasms/physiopathology , Anal Gland Neoplasms/surgery , Anal Gland Neoplasms , Crohn Disease/physiopathology , Crohn Disease , Magnetic Resonance Imaging/instrumentation , Magnetic Resonance Imaging/methodsSubject(s)
Colitis, Ulcerative/complications , Cytomegalovirus Infections/etiology , Cytomegalovirus/pathogenicity , Postoperative Complications , Pouchitis/etiology , Adult , Colitis, Ulcerative/therapy , Colitis, Ulcerative/virology , Cytomegalovirus Infections/diagnosis , Humans , Male , Proctocolectomy, Restorative , PrognosisSubject(s)
Humans , Female , Aged , Enterocolitis, Pseudomembranous/diagnosis , Enterocolitis, Pseudomembranous/microbiology , Methicillin/therapeutic use , Metronidazole/therapeutic use , Clostridium Infections/complications , Clostridium Infections/drug therapy , Clostridium/isolation & purification , Risk Factors , Bacteremia/complications , Bacteremia/diagnosis , Enterocolitis, Pseudomembranous/drug therapy , Enterocolitis, Pseudomembranous/physiopathology , Abdominal Pain/complications , Abdominal Pain/etiology , Clostridium , Clostridioides difficile/isolation & purification , Clostridioides difficile/pathogenicitySubject(s)
Crohn Disease/physiopathology , Crohn Disease/virology , Epstein-Barr Virus Infections/complications , Herpesvirus 4, Human/pathogenicity , Lymphohistiocytosis, Hemophagocytic/etiology , Adult , Epstein-Barr Virus Infections/virology , Humans , Lymphohistiocytosis, Hemophagocytic/pathology , Male , Prognosis , Young AdultABSTRACT
Severe lower gastrointestinal (GI) bleeding is an infrequent complication in Crohn's disease. We report the cases of three patients with Crohn's disease, localized in distinct areas, who developed severe enterorrhagia requiring multiple transfusions. All three patients responded favorably to infliximab administration, which resolved the life-threatening hemorrhages and avoided emergency surgical resection, which had seemed inevitable. Based on this clinical experience and a review of the literature comparing infliximab with other pharmacological options, we believe that this drug should be the treatment of choice in patients with Crohn's disease who develop severe lower gastrointestinal bleeding. This strategy can, in some cases, avoid surgery if the bleeding stops due to rapid healing of the deep mucosal lesions causing the hemorrhagic episode.
