ABSTRACT
BACKGROUND: Food oral immunotherapy (OIT) involves the administration of the food allergen causing the symptoms, in order to induce tolerance. Primary eosinophilic gastrointestinal disorders (PEGDs) are characterised by an eosinophil-rich inflammation affecting different locations of the digestive tract. We present a series of patients with PEGDs in a group of children following OIT with milk and/or egg. MATERIAL AND METHODS: A prospective study during the period 2006-2014 was performed in paediatric patients subjected to OIT with milk and/or egg. When these children present persistent gastrointestinal symptoms, they are referred to the Paediatric Gastroenterology Unit for evaluation. RESULTS: Primary eosinophilic gastrointestinal disorders were diagnosed in eight of the 128 cases of OIT (6.25%). The time to PEGDs development was variable: two cases showed symptoms during OIT, and the rest with a median time of 29 months (15-48 months). Food treatment discontinuation was not required in four of the five cases of eosinophilic oesophagitis, although food removal was necessary in patients with eosinophilic gastroenteritis. CONCLUSIONS: We report the highest prevalence of PEGDs in children subjected to OIT, and the first cases of eosinophilic gastroenteritis following food OIT. The monitoring of new digestive signs and symptoms after OIT is crucial for the diagnosis of these disorders, and prolonged follow-up is required. The management of such patients and the need or not to eliminate the food should be assessed on an individualised basis, according to the severity of the condition, its evolution and response to different treatment alternatives
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Subject(s)
Humans , Child, Preschool , Child , Eosinophilic Esophagitis/epidemiology , Eosinophilia/epidemiology , Gastrointestinal Diseases/immunology , Desensitization, Immunologic/statistics & numerical data , Immune Tolerance/immunology , Prospective Studies , Endoscopy, Gastrointestinal , BiopsyABSTRACT
BACKGROUND: Food oral immunotherapy (OIT) involves the administration of the food allergen causing the symptoms, in order to induce tolerance. Primary eosinophilic gastrointestinal disorders (PEGDs) are characterised by an eosinophil-rich inflammation affecting different locations of the digestive tract. We present a series of patients with PEGDs in a group of children following OIT with milk and/or egg. MATERIAL AND METHODS: A prospective study during the period 2006-2014 was performed in paediatric patients subjected to OIT with milk and/or egg. When these children present persistent gastrointestinal symptoms, they are referred to the Paediatric Gastroenterology Unit for evaluation. RESULTS: Primary eosinophilic gastrointestinal disorders were diagnosed in eight of the 128 cases of OIT (6.25%). The time to PEGDs development was variable: two cases showed symptoms during OIT, and the rest with a median time of 29 months (15-48 months). Food treatment discontinuation was not required in four of the five cases of eosinophilic oesophagitis, although food removal was necessary in patients with eosinophilic gastroenteritis. CONCLUSIONS: We report the highest prevalence of PEGDs in children subjected to OIT, and the first cases of eosinophilic gastroenteritis following food OIT. The monitoring of new digestive signs and symptoms after OIT is crucial for the diagnosis of these disorders, and prolonged follow-up is required. The management of such patients and the need or not to eliminate the food should be assessed on an individualised basis, according to the severity of the condition, its evolution and response to different treatment alternatives.
Subject(s)
Desensitization, Immunologic/methods , Enteritis/epidemiology , Eosinophilia/epidemiology , Eosinophilic Esophagitis/epidemiology , Eosinophils/immunology , Food Hypersensitivity/epidemiology , Gastritis/epidemiology , Gastrointestinal Tract/immunology , Allergens/immunology , Child , Child, Preschool , Egg Proteins/immunology , Enteritis/therapy , Eosinophilia/therapy , Eosinophilic Esophagitis/therapy , Follow-Up Studies , Food Hypersensitivity/therapy , Gastritis/therapy , Humans , Infant , Inflammation/immunology , Milk Proteins/immunology , Prevalence , Prospective Studies , Spain/epidemiologyABSTRACT
El edema agudo hemorrágico del lactante (EAHL) es una enfermedad infrecuente de curso benigno, de aparición entre los tres meses y los dos años de edad. De forma excepcional debuta en el periodo neonatal. Se caracteriza por la aparición de lesiones cutáneas eritematosas y purpúricas de predominio en miembros inferiores y región facial, que tienden a la resolución espontánea en días o semanas. Presentamos el caso de un edema agudo hemorrágico de aparición neonatal en una niña de 17 días de vida, valorada en nuestro servicio (AU)
Acute hemorrhagic edema of infancy is an infrequent disease with a benign course that appears between 3 months and 2 years old and, exceptionally, during the neonatal period. It is characterized by erythematous edema and purpuric lesions involving mainly the face and extremities, with a spontaneous recovery in days to weeks. We report a case of acute hemorrhagic edema with a neonatal onset in a 17 days-old girl, followed in our service recently (AU)
