Ethanol exposure perturbs sea urchin development and disrupts developmental timing.

Ethanol is a known vertebrate teratogen that causes craniofacial defects as a component of fetal alcohol syndrome (FAS). Our results show that sea urchin embryos treated with ethanol similarly show broad skeletal patterning defects, potentially analogous to the defects associated with FAS. The sea urchin larval skeleton is a simple patterning system that involves only two cell types: the primary mesenchymal cells (PMCs) that secrete the calcium carbonate skeleton and the ectodermal cells that provide migratory, positional, and differentiation cues for the PMCs. Perturbations in RA biosynthesis and Hh signaling pathways are thought to be causal for the FAS phenotype in vertebrates. Surprisingly, our results indicate that these pathways are not functionally relevant for the teratogenic effects of ethanol in developing sea urchins. We found that developmental morphology as well as the expression of some ectodermal and PMC genes was delayed by ethanol exposure. Temporal transcriptome analysis revealed significant impacts of ethanol on signaling and metabolic gene expression, and a disruption in the timing of GRN gene expression that includes both delayed and precocious gene expression throughout the specification network. We conclude that the skeletal patterning perturbations in ethanol-treated embryos likely arise from a loss of temporal synchrony within and between the instructive and responsive tissues.

Periprosthetic joint infections in femoral neck fracture patients treated with hemiarthroplasty - should we use antibiotic-loaded bone cement?

BACKGROUND: Hemiarthroplasty is the most common treatment in elderly patients with displaced intra-capsular femoral neck fracture (FNF). Prosthetic joint infection (PJI) is one of the most feared and frequent complications post-surgery because of the frail health status of these patients and the need for fast track surgery. Therefore, priorities should lie in effective preventive strategies to mitigate this burden. AIM: To determine how much the implementation of the routine use of antibiotic-loaded bone cement (ALBC) as a relatively easy-to-apply amendment to the surgical practice reduces the infection rate in our hemiarthroplasty cohort. METHODS: We retrospectively assessed all demographic, health status and treatment-related data of our FNF patients undergoing cemented hemiarthroplasty in the period from 2011 to 2017; 241 patients were further analyzed after exclusion of patients with cancer-related sequelae and those who died before the end of the 1-year observation period. The PJI rate as diagnosed on basis of the Musculoskeletal Infection Society (MSIS) criteria 2011 was determined for each included patient and compared in function of the bone cement used for hip stem fixation. Patients were split into a group receiving a plain bone cement in the period from January 2011 to June 2013 (non-ALBC group) and into a group receiving an ALBC in the period July 2013 to December 2017 (ALBC group). Data analysis was performed with statistical software. We further calculated the cost-efficacy of the implementation of routine use of ALBC in the second group balancing the in-hospital infection related treatment costs with the extra costs of use of ALBC. RESULTS: In total 241 FNF patients who received cemented hemiarthroplasty in the period from January 2011 to January 2017 were eligible for inclusion in this retrospective study. There were 8 PJI cases identified in the ALBC group among n = 94 patients, whereas 28 PJI cases were observed in the non-ALBC group among n = 147 patients. The statistical analysis showed an infection risk reduction of 55.3% (in particular due to the avoidance of chronic delayed infections) in the ALBC group (95%CI: 6.2%-78.7%; P = 0.0025). The cost-evaluation analysis demonstrated a considerable cost saving of 3.500 € per patient, related to the implementation of routine use of ALBC in this group. CONCLUSION: Use of ALBC is a potent infection preventive factor in FNF patients receiving cemented hemiarthroplasties. It was further found to be highly cost-effective.

Collective dynamics of molecular rotors in periodic mesoporous organosilica: a combined solid-state 2H-NMR and molecular dynamics simulation study.

Molecular rotors offer a platform to realize controlled dynamics and modulate the functions of solids. The motional mechanisms in arrays of rotors have not been explored in depth. Crystal-like porous organosilicas, comprising p-phenylene rotators pivoted onto a siloxane scaffold, were modelled using molecular dynamics (MD) simulations. Long simulations, on a microsecond scale, allowed to follow the reorientation statistics of rotor collections and single out group configurations and frequency distributions as a function of temperature. The motions observed in the MD simulations support a multiple-site model for rotor reorientations. Computed motional frequencies revealed a complex rotatory phenomenon combining an ultra-fast libration motion (oscillation up to 30°) with a slow and fast 180° flip reorientation. Adopting a multiple-site model provides a more accurate simulation of the 2H-NMR spectra and a rationalization of their temperature dependence. In particular, rotators endowed with distinct rates could be explained by the presence of slower rings locked in a T-shaped conformation.

A Molecular Interpretation of the Dynamics of Diffusive Mass Transport of Water within a Glassy Polyetherimide.

The diffusion process of water molecules within a polyetherimide (PEI) glassy matrix has been analyzed by combining the experimental analysis of water sorption kinetics performed by FTIR spectroscopy with theoretical information gathered from Molecular Dynamics simulations and with the expression of water chemical potential provided by a non-equilibrium lattice fluid model able to describe the thermodynamics of glassy polymers. This approach allowed us to construct a convincing description of the diffusion mechanism of water in PEI providing molecular details of the process related to the effects of the cross- and self-hydrogen bonding established in the system on the dynamics of water mass transport.

Traumatic quadruple amputee rehabilitation: from amputation to prosthetic functionality: a case report.

INTRODUCTION: Traumatic quadruple amputations limit daily living activities; however, the current literature regarding rehabilitation treatment for multi-limb amputations is scant. The patient showed adaptation to prosthetic fittings, acquiring a level of functional independence that enabled the patient to lead a nearly independent life. METHODS: The patient's therapeutic intervention was divided into a pre-prosthetic phase, which consisted of functional physical adaptation to the amputation and preparation for the prostheses, and a prosthetic phase, in which different myoelectric and microprocessor limb prostheses were integrated to be used functionally. Its functional use was favored by the training with contact electromyography feedback carried out with the Biometrics E-Link System® for the upper extremities that has made it possible to obtain many grip options in a natural way, for the lower extremities the use of the intelligent passive prostheses has overcome the functional capacity achieved in this type of patients referenced in the literature who had used prostheses of previous generations such as mechanical passive prostheses. RESULTS: With rehabilitation, the patient showed improvements in the following scales and questionnaires (initial vs. final values): Disabilities of the Arm, Shoulder, and Hand Questionnaire; Functional Independence Measure; Berg Balance Scale; Locomotor Capabilities Index in Amputees (an assessment of overall motor capacity); and Special Interest Group in Amputee Medicine scale (an assessment of the degree of mobility). CONCLUSIONS: The patient's age, psychological status, and family and personal support, in addition to technical and economic resources used for next-generation prostheses adapted to this clinical case, were crucial for his progress. IMPLICATIONS FOR REHABILITATION The use of next-generation myoelectric and microprocessor prostheses makes it possible to achieve greater end functionality in quadruple amputees. Proximal amputation levels present greater difficulty in achieving good functionality. Early and intensive rehabilitation could favour and contribute towards improving psychological states. Age, psychological status, and pain management are aspects to take into account during the rehabilitation process.

DENV and ZIKV detection in patients with acute febrile syndrome in Córdoba, Colombia.

OBJECTIVE: To determine simultaneous circulation of DENV serotypes and ZIKV in Córdoba, Colombia, during 2015 and 2016. MATERIAL AND METHODS: A total of 294 samples from patients with clinical diagnosis of febrile syndrome compatible with dengue were collected between June 2015 and December 2016. All samples were tested for DENV and ZIKV by RT-PCR using C6/36 cells culture supernatant. RESULTS: Thirty-three percent of the samples were positive (97/294); from these, 61.8% were positive for DENV and 31% were positive for Zika. The predominant serotype was DENV-2 (70.1%), followed by DENV-3 (8.9%), DENV-4 (6%), and DENV-1 (3%). DENV/ZIKV coinfection was identified in 7.2% of the cases associated with DENV-1 and DENV-3 serotypes. The confirmed cases of dengue, Zika, and DENV/ZIKV coinfections were clinically mild and self-limited. CONCLUSIONS: We reported the co-circulation of all four DENV serotypes, with a higher frequency of DENV-2, and ZIKV introduction in Córdoba department-Colombia in August 2015. This scenario favored the appearance of DENV/ZIKV coinfections.

In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting.

BACKGROUND: For decades, bioprospecting has proven to be useful for the identification of compounds with pharmacological potential. Considering the great diversity of Colombian plants and the serious worldwide public health problem of dengue-a disease caused by the dengue virus (DENV)-in the present study, we evaluated the anti-DENV effects of 12 ethanolic extracts derived from plants collected in the Colombian Caribbean coast, and 5 fractions and 5 compounds derived from Psidium guajava. METHODS: The cytotoxicity and antiviral effect of 12 ethanolic extracts derived from plants collected in the Colombian Caribbean coast was evaluated in epithelial VERO cells. Five fractions were obtained by open column chromatography from the ethanolic extract with the highest selectivity index (SI) (derived from P. guajava, SI: 128.2). From the fraction with the highest selectivity (Pg-YP-I-22C, SI: 35.5), five compounds were identified by one- and two-dimensional nuclear magnetic resonance spectroscopy. The antiviral effect in vitro of the fractions and compounds was evaluated by different experimental strategies (Pre- and post-treatment) using non-toxic concentrations calculated by MTT method. The DENV inhibition was evaluated by plate focus assay. The results were analyzed by means of statistical analysis using Student's t-test. Finally the antiviral effect in Silico was evaluated by molecular docking. RESULTS: In vitro evaluation of these compounds showed that three of them (gallic acid, quercetin, and catechin) were promising antivirals as they inhibit the production of infectious viral particles via different experimental strategies, with the best antiviral being catechin (100% inhibition with a pre-treatment strategy and 91.8% with a post-treatment strategy). When testing the interactions of these compounds with the viral envelope protein in silico by docking, only naringin and hesperidin had better scores than the theoretical threshold of - 7.0 kcal/mol (- 8.0 kcal/mol and - 8.2 kcal/mol, respectively). All ligands tested except gallic acid showed higher affinity to the NS5 protein than the theoretical threshold. CONCLUSION: Even though bioprospecting has recently been replaced by more targeted tools for identifying compounds with pharmacological potential, our results show it is still useful for this purpose. Additionally, combining in vitro and in silico evaluations allowed us to identify promising antivirals as well as their possible mechanisms of action.

Evaluación clínica objetiva estructurada sobre competencias comunicativas y psicosociales en odontología / Objective structured clinical examination of or about health communication and psychosocial factors in Dentistry

Introducción: La Facultad de Odontología de la Universidad de Chile, en el contexto de su innovación curricular, desarrolló una evaluación clínica objetiva estructurada de carácter formativo utilizando la metodología de pacientes simulados y enfocada a las habilidades comunicacionales que debe tener el estudiante para el adecuado desarrollo de una entrevista clínica. Objetivo: Describir el desempeño, en cuanto a habilidades comunicacionales e identificación de factores psicosociales, durante la realización de esta actividad, de estudiantes de segundo año. Sujetos y métodos: Estudio no experimental, transversal, descriptivo, con un muestreo intencionado de 32 estudiantes. Los pacientes simulados y el grupo de pares evaluaron el desempeño de los 32 estudiantes. Se realizaron análisis descriptivos a través de tablas de frecuencia y se evaluó la diferencia en la percepción de desempeño entre paciente simulado y grupo de pares mediante chi al cuadrado. Resultados: Los estudiantes no lograron un buen desempeño al indagar por aspectos socioemocionales del paciente, ni al asegurarse de que el paciente comprendiera las indicaciones del dentista. La percepción de los pacientes simulados y los pares observadores difiere en casi todos los aspectos evaluados, menos en la amabilidad del estudiante participante. Conclusiones: Los pacientes simulados son más estrictos a la hora de evaluar las habilidades comunicacionales y psicosociales de los estudiantes, en comparación con el grupo de pares. La consideración de los factores psicosociales y las habilidades comunicacionales constituyen un factor débil al término del segundo año de formación del odontólogo

Introduction: The School of Dentistry of the Universidad de Chile has done an objective structured clinical evaluation centered on communicative competencies that a student should have for the proper development of a clinical interview. Aim: To describe the perception of achievement, in the matter of communicative and psychosocial competencies in students of second grade acting in this activity, on the career of dentistry at Universidad de Chile. Subjects and methods: This is a non-experimental, cross-sectional, descriptive study, with a purposive sampling of 32 students. The simulated patients and the group of pairs evaluated the achievement of 32 students on the activity. Descriptive analysis was done through frequency tables. In addition, the difference on perception of achievement between simulated patient and group of pairs was evaluated through chi-squared test. Results: The students did not achieve a satisfactory performance when socioemotional attributes were probed, neither when verifying patient's understanding about dentist's indications. The perception of simulated patients and observer pairs disagrees on almost all attributes assessed, excepting the kindness of the performing student. Conclusions: Simulated patients are more stringent when they evaluate communicative and psychosocial abilities of the students, contrasting with the group of pairs. Psychosocial and communicative attributes are still a weakness on dentist's preparation

A (re) paginação do instrumento de avaliação de estágios curriculares de enfermagem / The (re) paging of the instrument of evaluation of nursing curricular stages

Acredita-se que a avaliação é fundamental na formação profissional, pois no processo ensinoaprendizagem viabiliza o crescimento e a construção de resultados satisfatórios de aprendizagem. Isto implica dizer que a avaliação deve contribuir para a formação de profissionais críticos e reflexivos alterando, por vezes, a realidade na qual exercerá a profissão, portanto o processo de avaliação é dinâmico e requer adequações constantes

Structural Characterization of Electron Donors in Ziegler-Natta Catalysts.

Ziegler-Natta catalysis is a very important industrial process for the production of polyolefins. However, the catalysts are not well-understood at the molecular level. Yet, atomic-scale structural information is of pivotal importance for rational catalyst development. We applied a solid-state NMR/density functional theory tandem approach to gain detailed insight into the interactions between the catalysts' support, MgCl2, and organic electron donors. Because of the heterogeneity of the samples, large line widths are observed in the carbon spectra. Despite this, good agreement between experimental and computational values was reached, and this shows that 1,3-diether based donors coordinate at (110) surface sites, while phthalates are less selective and coordinate at both (104) and (110) surface sites.

On the calculation of the potential of mean force between atomistic nanoparticles.

We study the potential of mean force (PMF) between atomistic silica and gold nanoparticles in the vacuum by using molecular dynamics simulations. Such an investigation is devised in order to fully characterize the effective interactions between atomistic nanoparticles, a crucial step to describe the PMF in high-density coarse-grained polymer nanocomposites. In our study, we first investigate the behavior of silica nanoparticles, considering cases corresponding to different particle sizes and assessing results against an analytic theory developed by Hamaker for a system of Lennard-Jones interacting particles (H.C. Hamaker, Physica A 4, 1058 (1937)). Once validated the procedure, we calculate effective interactions between gold nanoparticles, which are considered both bare and coated with polyethylene chains, in order to investigate the effects of the grafting density [Formula: see text] on the PMF. Upon performing atomistic molecular dynamics simulations, it turns out that silica nanoparticles experience similar interactions regardless of the particle size, the most remarkable difference being a peak in the PMF due to surface interactions, clearly apparent for the larger size. As for bare gold nanoparticles, they are slightly interacting, the strength of the effective force increasing for the coated cases. The profile of the resulting PMF resembles a Lennard-Jones potential for intermediate [Formula: see text], becoming progressively more repulsive for high [Formula: see text] and low interparticle separations.

Stigma-related access barriers and violence against trans women in the Colombian healthcare system.

Drawing from qualitative research conducted in a participatory action research framework with 28 transgender women in Colombia, this paper presents the stigma-related barriers to healthcare experienced by trans women and their experiences of multi-level violence within the healthcare system. The authors also discuss how advocacy work was conducted as part of the research process and how trans community leaders were involved throughout the project in order to promote policy-relevance and community-based implementation of findings. The paper concludes with a discussion of how the experiences of violence and stigmatisation within the health care system is linked to broader processes of structural stigma reproduced within Colombian society.

Biomembrane solubilization mechanism by Triton X-100: a computational study of the three stage model.

The solubilization mechanism of lipid membranes in the presence of Triton X-100 (TX-100) is investigated at molecular resolution using molecular dynamics (MD) simulations. Thanks to the large time and length scales accessible by the hybrid particle-field formulation of the models employed here, the complex process of membrane solubilization has been studied, with the goal of verifying the three stage model reported in the literature. DPPC lipid bilayers and vesicles have been studied at different concentrations of the TX-100 detergent employing coarse grained (CG) models. Systems up to ∼600.000 beads, corresponding to more than 2 millions heavy atoms, have been simulated. Moreover, in order to clarify several experimental pieces of evidence, both slow and fast detergent partition scenarios have been investigated. Flat and curved (vesicles) lipid bilayer surfaces, interacting with TX-100, have been considered to study the curvature effects on the detergent partition rate in the membrane. Shape and conformational changes of mixed DPPC/TX-100 vesicles, as a function of TX-100 content, have also been studied. In particular, high curvature surfaces, corresponding to a higher local TX-100 content, promote a membrane rupture. In flat lipid surfaces, on the time scale simulated the detergent partition is almost absent, following a different pathway of the solubilization membrane mechanism.

Local Structure and Dynamics of Water Absorbed in Poly(ether imide): A Hydrogen Bonding Anatomy.

Hydrogen bonding (HB) interactions play a major role in determining the behavior of macromolecular systems absorbing water. In fact, functional and structural properties of polymer-water mixtures are affected by the amount and type of these interactions. This contribution aims at a molecular level understanding of the interactional scenario for the technologically relevant case of the poly(ether imide)-water system. The problem has been tackled by combining different experimental and theoretical approaches which, taken together, provide a comprehensive physical picture. Relevant experimental data were gathered by in situ FTIR spectroscopy, while molecular dynamics (MD) and statistical thermodynamics approaches were used as modeling theoretical tools. It was found that, among the possible configurations, some are strongly prevailing. In particular, water molecules preferentially establish water bridges with two carbonyl groups of the same PEI repeating unit. Water self-interactions were also detected, giving rise to a "second shell" species in the prevalent form of dimers. The population of the different water species was evaluated spectroscopically, and a remarkable agreement with theoretical predictions was found.

Inhibición del crecimiento de Erwinia chrysanthemi a diferentes concentraciones de ácido fólico: posible uso del ácido fólico como agente bacteriostático y fortificante de la papa Solanum tuberosum / Inhibition of Erwinia chrysanthemi growth to different concentrations of folic acid: possible use of folic acid as bacteriostatic agent and fortifying of Solanum tuberosum potato

Resumen Introducción: Las enterobacterias del genero Erwinia spp producen enfermedades en la papa, un tubérculo de consumo masivo. La regulación de la metilación del DNA puede regular la proliferación de la Erwinia, de tal modo que las concentraciones del ácido fólico, pueden tener un efecto en la capacidad patógena del microorganismo. De otra parte, el ácido fólico previene la aparición de defectos del tubo neural en humanos. Objetivo: Evaluar al ácido fólico como un agente bacteriostático de la Erwinia y que a su vez sea parte de la fortificación de alimentos de consumo masivo como la papa. Materiales y métodos: Se llevó a cabo la caracterización bioquímica de la Erwinia chrysanthemi, se estudió su crecimiento frente a diferentes concentraciones de ácido fólico Resultados: Al aumentar las concentraciones de la vitamina, desde 0,3 µg/L hasta 6,8 µg/L se inhibe el crecimiento bacteriano de la Erwinia chrysanthemi. La vitamina inhibe el crecimiento en cultivo de Erwinia chrysanthemi y actúa como como agente bacteriostático, aspecto es de gran relevancia dado que teóricamente, si la papa estuviera fortificada con el micronutriente, este actuaría contra el agente infeccioso y al mismo tiempo contribuiría al consumo adecuado de la vitamina en la población general.

Abstract Introduction: The enterobacteria of the Erwinia spp genus produce disease in potatoes, which is a tuber of mass consumption. The regulation of DNA methylation can regulate the proliferation of Erwinia in such a way that the concentrations of folic acid may have an effect on the microorganism pathogenic ability. On the other hand, the folic acid prevents the appearance of neural tube defects in humans. Objective: To evaluate folic acid as a bacteriostatic agent of Erwinia and, at the same time, as part of the fortification of mass consumption food such as the potatoes. Materials and methods: The biochemical characterization of the Erwinia chrysanthemi was carried out and its growth compared to different concentrations of folic acid was studied. Results: When increasing the concentrations of the vitamin from 0.3 µg/L up to 6.8 µg/L, the bacterial growth of Erwinia chrysanthemi is inhibited. The vitamin inhibits the growth in cultivation of Erwinia chrysanthemi and acts as a bacteriostatic agent. This aspect is of great importance given that, theoretically, if potatoes were fortified with micro-nutrient, this would act against the infectious agent and, at the same time, contribute to the adequate intake of the vitamin in the general population.

Pérdida de la agudeza visual como primera manifestación del cáncer de páncreas: Reporte de caso / Visual acuity loss as first manifestation of pancreatic cancer: Case report

Las metástasis oculares constituyen el tumor maligno intraocular más frecuente en la población adulta. Estas tienen en su mayoría un compromiso coroideo. Se describe el caso de una paciente que presentó disminución de la agudeza visual rápidamente progresiva en el ojo derecho. Sin antecedentes personales relevantes, durante la evaluación oftalmológica se observa una lesión coroidea, la cual clínica y radiológicamente sugería una metástasis coroidea como primera impresión diagnóstica. Posterior a la realización de estudios de extensión se confirmó histopatológicamente un tumor pancreático como origen de la metástasis. Las metástasis oculares ocasionadas por el páncreas son extremadamente raras, lo cual se confirma en la revisión de la literatura realizada.

The ocular metastases are the most common intraocular malignant tumor in the adult population. These have mostly a choroid commitment. This case report describes a female patient who presented with a rapidly progressive decrease in visual acuity in the right eye, no other symptoms were referred and her medical history was no relevant. A choroidal lesion was found, which clinically and radiologically suggested a choroid metastasis as the diagnosis. With extension studies was confi rmed histopathologically a pancreatic tumor as the primary tumor. The ocular metastases that are originated for the pancreas are extremely rare; this is confirmed by the review of the literature.

First Report of AIDS-Related Burkitt's Lymphoma Presenting as Bilateral Orbital Masses.

Burkitt's lymphoma (BL) is an aggressive B-cell non-Hodgkin's lymphoma and one of the fastest growing tumors in humans. It is an acquired immunodeficiency syndrome- (AIDS-) defining disease and occurs with relatively preserved CD4 cell counts. It rarely affects the orbital region in the setting of AIDS. We report unusual presentation of a fatal case of AIDS-associated BL in a 42-year-old female patient with severe CD4 cell depletion who presented with dramatic fast growing (within days) bilateral orbital masses leading to striking facial deformities. To the best of our knowledge, this is the first report of bilateral orbital involvement in AIDS-associated BL.

MicroRNA-21 predicts response to preoperative chemoradiotherapy in locally advanced rectal cancer.

PURPOSE: The treatment of choice for locally advanced rectal cancer is preoperative chemoradiotherapy. Despite half of patients do not respond and suffer unnecessary toxicities and surgery delays, there are no biomarkers to guide preoperative CRT outcome. MicroRNA-21 has been related to acquisition of 5-fluorouracil resistance; however, its potential predictive value of response to preoperative chemoradiotherapy in locally advanced rectal cancer remains unknown. METHODS: Nighty-two patients diagnosed with locally advanced rectal cancer who were preoperatively treated with chemoradiotherapy were selected for this study. Moreover, microRNA-21 expression was quantified in formalin-fixed paraffin-embedded biopsies from this cohort, and the results obtained were correlated with clinical and molecular characteristics, pathological response, and outcome. RESULTS: MicroRNA-21 was found overexpressed in 77.6% cases, and significantly correlated with tumor grade after preoperative chemoradiotherapy (P = 0.013) and with pathological response (P = 0.013). The odds ratio of having miR-21 overexpression and not getting a respond to chemoradiotherapy resulted in 9.75 CI 2.24 to 42. Sensitivity, specificity, negative predictive values, and positive predictive value were 86.6, 60, 42.8, and 92%, respectively. Multivariate analysis confirmed the clinical significance of miR-21 determining preoperative chemoradiotherapy response. CONCLUSIONS: MicroRNA-21 expression efficiently predicts preoperative chemoradiotherapy pathological response in locally advanced rectal cancer.

Audição em adultos e idosos: associação com sexo, idade e cognição / Hearing in middle aged adults and elderly: association with gender, age and cognitive performance

OBJETIVO: verificar a existência de associação entre a presença e o grau de perda auditiva em adultos e idosos e o desempenho em teste de rastreio cognitivo, o sexo e a idade dos mesmos. MÉTODOS: participaram deste estudo sujeitos com idade entre 52 e 92 anos. Todos responderam a questionário sócio-demográfico, ao teste de Mini Exame do Estado Mental e à audiometria tonal liminar. RESULTADOS: dos 90 indivíduos avaliados, 22 (24,4%) eram do sexo masculino e 68 (75,6%) do sexo feminino. Constatou-se que apenas 11 orelhas direitas e 11 orelhas esquerdas apresentavam limiares auditivos normais. Constatou-se que a idade estava associada com o aumento dos limiares auditivos, evidenciando que os indivíduos mais velhos apresentam maior grau de perda auditiva (p<0,005). Não houve diferença estatística entre os limiares auditivos de homens e mulheres (p=0,1). Observou-se que 80% dos sujeitos cujo resultado do rastreio cognitivo foi normal apresentaram os limiares auditivos menos afetados. Já 60% dos indivíduos cujo resultado do rastreio cognitivo foi alterado apresentaram maior grau de perda auditiva. Pode-se constatar a relação dos achados audiológicos com os resultados do teste de rastreio cognitivo, evidenciando que os sujeitos com o resultado alterado do mini Exame do Estado mental apresentam os maiores graus de perda auditiva (p<0,001). CONCLUSÃO: verificou-se que houve associação entre a presença e grau da perda auditiva com o resultado do Mini Exame do Estado Mental. O aumento da idade mostrou-se proporcional ao aumento dos limiares auditivos. Não foi constatada associação entre gênero e audição na amostra. .

PURPOSE: to verify whether the presence and level of hearing loss in adults and elderly as well as their performance in tests are linked to their gender, age and cognitive tracking. METHODS: subjects with ages between 52 and 92 years old took part in this study. They all answered a sociodemographic questionnaire and went through Mini-Mental State Examination as well as pure-tone threshold audiometry. RESULTS: out of the 90 individuals, 22 (24,4%) were male and 68 (75,6%) were female. It was seen that only 11 right ears and 11 left ears presented normal auditory thresholds. It was possible to verify that age was indeed linked to the auditory thresholds increase, making it clear that older individuals present higher levels of hearing loss (p<0,005). There was no statistical difference between the auditory thresholds of male and female (p=0,1). It was observed that 80% of the individuals whose cognitive tracking results were normal presented least affected auditory thresholds, while 60% of those whose cognitive tracking results were altered presented a higher level of hearing loss. It is possible to identify a relation between these audiological findings and the cognitive tracking test results, proving that the individuals with the altered Mini-Mental State Examination results present higher hearing loss (p<0,001). CONCLUSION: there was an association between the presence and degree of hearing loss with the result of the Mini-Mental State Examination. Increasing age was proportional to the increase in hearing thresholds. There was no association between gender and hearing in the sample. .

Jogos eletrônicos, psicodrama e imaginação / Video-games, psychodrama and imagination

Crianças e adolescentes, assim como muitos adultos, tornaram-se usuários de uma forma de entretenimento polêmica, embora atualmente banalizada: os jogos eletrônicos. Este artigo propõe uma reflexão que articula conceitos do Psicodrama ao universo da imaginação nos jogos eletrônicos. Será que os jogos podem propiciar exercícios de criação ou são apenas mecânicos e estimulam a rigidez no desempenho de papéis sociais e imaginários? Como podemos conceber a experiência das crianças que, fascinadas pelo prazer de simular outra realidade, a virtual, criam personagens e histórias todos os dias nas telas do computador? Seria possível nos aproximar dessa linguagem de comunicação, de forma que compreendêssemos qual o seu sentido para os jogadores?.

Children and adolescents, as well as many adults have become users of a controversial, yet still banalized form of entertainment: video-games. This article offers a reflection connecting psychodramatic concepts with the universe of imagination of video-games. Is it possible that these games can propitiate creativity, or are they simply mechanical and stimulate rigidity in the performance of social and imaginary roles? How can we understand the experience of children who, fascinated by the pleasure of simulating another virtual reality, end up every day creating characters and stories on their computer screens? Can we approach this language of communication in order to better understand its meaning for the players?.