ABSTRACT
Objective To investigate the characteristics of adverse drug reaction( ADR) in Shengli Oil Field Central Hospital and promote clinical rational use of drug.Methods 540 ADR cases collected in our hospital during 2014 were analyzed statistically in terms of patients'age and gender,drug types and route of administration,clinical manifestation etc.Results The 540 ADR cases occurred in male/female ratio of 1.01:1;209 cases(38.7%) aged≥60 years;425 cases(78.7%) were induced via intravenous injection;69 cases(12.8%) were induced by oral drugs;the anti-infective drugs ranked the first in terms of ADR incidence;285 cases ( 35.14%) manifested as lesions of skin and its appendants;148 cases involved the basic drugs.Conclusion It is important to strengthen ADR monitoring in hospital and achieve rational and standard use of anti-infective drugs so as to avoid or reduce the occurrence of severe ADR.
ABSTRACT
A simple, reliable, and reproducible method for in-vivo on-line separation and determination of levodopa has been based on microdialysis then high-performance liquid chromatography with chemiluminescence detection. The perfusate is perfused at a flow rate of 5 microL min(-1). The concentration of levodopa in the dialysate is determined on line with a chemiluminescence system. The dialysate sample volume is approximately 20 microL. The response of the system is linearly related to the concentration of levodopa in the range 1 x 10(-8) to 1 x 10(-6) g mL(-1) (r2 = 0.9995) with a detection limit (3sigma) of 3 x 10(-9) g mL(-1) and sample throughput of 12 h(-1); RSD is 2.8% (n = 11). The method has been successfully used to study the pharmacokinetics of levodopa in vivo; the values of the pharmacokinetics parameters Cmax, AUC(0-t) and Tmax were 16.60, 20.92 ng mL(-1), and 90 min, respectively.
