Meningeal carcinomatosis as the initial manifestation of lymphoma / Carcinomatosis meníngea como manifestación inicial de linfoma

Introduction: Leptomeningeal carcinomatosis (LC) is diagnosed in 4-15% of cancer patients, and most cases (70%) are in the advanced phase of the disease. In only 5-10% of patients with LC, it is the initial manifestation of cancer.Case report: We present a case of a 46-year-old man with leptomeningeal carcinomatosis as the first manifestation of type B high-grade lymphoma. Cerebrospinal fluid (CSF) showed pleocytosis with a predominance of mononuclear cells, hyperproteinorrhachia, and glucose consumption. CSF cytology was negative for malignant cells in two samples. Magnetic resonance imaging and CSF flow cytometry gave the diagnosis.Discussion: LC is a diagnostic challenge. Differential diagnosis arises with infectious processes (tuberculosis) and autoimmune diseases. In cerebrospinal fluid, flow cytometry (FCM) has a higher sensitivity than cytology for the diagnosis of LC.(AU)

Meningoangiomatosis: a propósito de un caso. Revisión de hallazgos en neuroimagen / Meningoangiomatosis: about a case review of findings in neuroimaging

La meningoangiomatosis es una lesión intracraneal benigna y poco frecuente, que afecta fundamentalmente a las leptomeninges y a la corteza cerebral subyacente, siendo más frecuente en niños y adultos jóvenes. Aunque la mayoría de casos se presentan de forma aislada, se ha descrito su asociación con síndromes como la neurofibromatosis tipo 2, estos últimos más frecuentemente asintomáticos y con buena respuesta farmacológica; sin embargo, las presentaciones esporádicas presentan un amplio espectro clínico, abarcando desde cefaleas crónicas hasta crisis convulsivas refractarias, llegando incluso a asociarse a lesiones intracraneales como los meningiomas. En este artículo presentamos nuestra experiencia con una paciente joven que debutó con un episodio de crisis epiléptica focal motora con evolución tónico-clónica generalizada y buena respuesta al tratamiento antiepiléptico. Dada la alta inespecificidad asociada a esta patología, tanto clínica como radiológica, nuestro objetivo es sintetizar los hallazgos radiológicos que nos permiten el planteamiento diagnóstico de esta entidad en pacientes clínicamente compatibles.(AU)

Meningoangiomatosis is a rare and benign intracranial affectation, affecting mainly leptomeninges and the underlying cerebral cortex, being more frequent in children and young adults. Although most of the cases are presented in an isolated way, it has been described its association with syndromes such as neurofibromatosis type 2, these last ones more frequently asymptomatic and with good pharmacological response; however, the sporadic presentations present a wide clinical spectrum, ranging from chronic headaches to refractory convulsive crisis, even being associated to intracranial lesions such as meningiomas.In this article we present our experience with a young patient who debuted with an episode of focal motor epileptic seizure with generalized tonic-clonic evolution and good response to antiepileptic treatment. Given the high unspecificity associated with this pathology, both clinical and radiological, our aim is to synthesize the radiological findings that allow us the diagnostic approach of this entity in clinically compatible patients.(AU)

Manejo de la patología mamaria en el servicio de radiodiagnóstico en un hospital de alta incidencia de COVID-19 / Breast pathology handling by breast radiologists in a high incidence hospital for COVID-19

En este artículo pretendemos exponer al lector como hemos realizado el manejo de la patología mamaria por parte de la Sección de Radiología durante la pandemia de COVID-19 en un hospital de alta incidencia, como ha sido el "Complejo Hospitalario Universtiario de Albacete", donde desarrollamos dicha actividad. Para ello, hemos revisado las principales guías de actuación propuestas por diferentes sociedades, haciendo una comparativa con el manejo que hemos realizado por parte de nuestro servicio y viendo si eran todas aplicables y óptimas o si nos hemos visto en la necesidad de modificar algunas de ellas en beneficio de las pacientes, debido tanto a la alta incidencia de patología mamaria no demorable como a la de COVID-19 en nuestra ciudad, siendo nuestro objetivo evitar al máximo el retraso diagnóstico de patología mamaria y sobre todo de cáncer de mama, así como evitar los contagios tanto del personal sanitario como de las pacientes

In this article we would like to show the reader how we have managed breast pathology along all pandemic COVID-19 period in our Radiology Department, as far as our Hospital ("Complejo Hospitalario Universtiario de Albacete") has been highly affected by COVID-19. To get to a result, we have revised main breast management guides porpused by different societies, and we have afterwards compared their recommendations with our way of handling the situation, taking into account that some of them were available and others were modified in order to benefit our patients. This was necessary in order to satisfy the attention of our patients with non delaying breast pathology and to manage correctly COVID-19 pandemic as well in a high incidence place. Our principal aims have been avoiding breast pathology diagnosis delay (breast cancer above all), as well as avoiding workers and patients COVID-19 infection

Importance of the Ultrasound Probe Angle on the Rotation Fill-in Signature in Ultrasound Axial-Shear Strain Imaging.

The rotation fill-in is a signature of tumor benignity in rotation elastograms and has been used for breast tumor classification. It is a consequence of the bonding condition at the tumor-tissue interface. In vivo studies have revealed the presence of fluctuations when inclined uniaxial external compression is applied. However, the physical meaning of these fluctuations is not yet fully understood. In this article we present an experimental and numerical study of the rotation fill-in signature as a function of the probe's tilt angle. This angle introduces asymmetries in the stress field, modifying the bonding condition. We numerically consider this asymmetry by using a model of friction with a simple angular dependence, which allows us to capture the experimental trends. We argue that the formulation of a tumor model with a bonding condition dependence may have potential implications in correct tumor classification.