ABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Angiomatosis/physiopathology , Abdominal Neoplasms/pathology , Cysts/pathologySubject(s)
Burkitt Lymphoma , Thyroid Neoplasms , Adult , Burkitt Lymphoma/diagnosis , Female , Humans , Thyroid Neoplasms/diagnosisABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Burkitt Lymphoma/pathology , Thyroid Neoplasms/pathology , Neoplasm Staging , Biomarkers, Tumor/analysisABSTRACT
In the context of a surgically treated abdominal wall pathology, eventration of the wall, or incisional hernia, is one of the most prevalent complications. Despite numerous improvements over the years in suture materials and closure techniques, the incidence of incisional hernia has not diminished. Several general factors can influence the wound healing process after a laparotomy, but there are also biological factors that depend on the individual patient that can to a great extent explain the un-changing incidence of this pathology. Thus, different types of collagen, certain enzymes such as metalloproteinases and factors such as smoking have been attributed a role in the appearance of incisional hernia. These features suggest the need for a biomaterial to strengthen laparotomy closures, especially midline closures, in high-risk patients and/or in those where wound healing is compromised.
Subject(s)
Hernia, Ventral/etiology , Laparotomy/adverse effects , Animals , Biocompatible Materials , Collagen/metabolism , Disease Models, Animal , Hernia, Ventral/surgery , Humans , Laparotomy/methods , Malnutrition/complications , Metalloproteases/metabolism , Multicenter Studies as Topic , Randomized Controlled Trials as Topic , Rats , Risk Factors , Smoking/adverse effects , Surgical Wound Infection/complications , Suture Techniques , Sutures , Time Factors , Wound HealingABSTRACT
En el contexto de la patología quirúrgica de la pared abdominal, la eventración o hernia incisional sigue siendo una de las afecciones de mayor prevalencia. Su incidencia no ha disminuido en los últimos años a pesar de la mejora en los materiales de sutura y también en las técnicas de cierre. Existen factores de índole general que pueden interferir en el proceso cicatricial de las laparotomías, pero hay factores de tipo biológico dependientes del propio individuo que pueden explicar en gran parte la inalterable incidencia de esta afección. Así, los diferentes tipos de colágenos, determinadas enzimas, como las metaloproteinasas, y ciertos hábitos, como el tabaquismo, han sido implicados en la aparición de esta afección. Probablemente sea necesario en casos de riesgo y cicatrización comprometida realizar los cierres laparotómicos con algún material protésico de apoyo, especialmente en las laparotomías medias (AU)
In the context of a surgically treated abdominal wall pathology, eventration of the wall, or incisional hernia, is one of the most prevalent complications. Despite numerous improvements over the years in suture materials and closure techniques, the incidence of incisional hernia has not diminished. Several general factors can influence the wound healing process after a laparotomy, but there are also biological factors that depend on the individual patient that can to a great extent explain the un-changing incidence of this pathology. Thus, different types of collagen, certain enzymes such as metalloproteinases and factors such as smoking have been attributed a role in the appearance of incisional hernia. These features suggest the need for a biomaterial to strengthen laparotomy closures, especially midline closures, in high-risk patients and/or in those where wound healing is compromised (AU)
Subject(s)
Humans , Hernia, Ventral/etiology , Laparotomy/adverse effects , Surgical Wound Infection/complications , Risk Factors , Wound Healing , Metalloproteases/analysis , Aortic Aneurysm/enzymology , Hernia, Ventral/enzymologyABSTRACT
Siempre se ha considerado que el cáncer de mama con metástasis a distancia es una enfermedad incurable y, consecuentemente, la paciente es candidata a recibir sólo tratamiento médico paliativo. Sin embargo, la obtención de mayores éxitos de supervivencia tras los nuevos regímenes terapéuticos en el cáncer de mama diseminado y la existencia de un 5% de enfermas con cáncer de mama metastásico confinado a un solo órgano sólido (estado oligometastásico) son dos aspectos determinantes en la introducción de la cirugía como parte integral en el tratamiento multidisciplinario de las metástasis hepáticas, pulmonares y óseas de origen mamario. Esta revisión actualiza las diferentes series publicadas centrando la discusión en dos aspectos: la selección de las candidatas ideales para la cirugía exerética de hígado, pulmón o partes óseas y la identificación de los factores pronósticos de recurrencia y/o supervivencia tras la extirpación de tales metástasis (AU)
Patients with distant metastases from breast cancer have always been considered terminally ill and as such candidates for palliative treatment only. However, due to new therapeutic modalities in oncology, survival in these patients has improved. Furthermore, in 5% of patients, metastasis from breast cancer is limited to a single solid organ (oligometastatic state). Because of these two factors, surgery is now being performed as a component of multidisciplinary treatment for hepatic, lung and bone metastases from a primary breast tumor. In the present article, we review the different published series, focussing discussion on two issues: selecting candidates for liver, lung or bone resection, and identifying prognostic factors for recurrence and/or survival following surgical excision of metastases to these sites (AU)
Subject(s)
Female , Adult , Middle Aged , Humans , Neoplasm Metastasis , Breast Neoplasms/complications , Disease-Free Survival , Liver Neoplasms/surgery , Liver Neoplasms/secondary , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Bone Neoplasms/secondary , Bone Neoplasms/surgeryABSTRACT
Patients with distant metastases from breast cancer have always been considered terminally ill and as such candidates for palliative treatment only. However, due to new therapeutic modalities in oncology, survival in these patients has improved. Furthermore, in 5% of patients, metastasis from breast cancer is limited to a single solid organ (oligometastatic state). Because of these two factors, surgery is now being performed as a component of multidisciplinary treatment for hepatic, lung and bone metastases from a primary breast tumor. In the present article, we review the different published series, focussing discussion on two issues: selecting candidates for liver, lung or bone resection, and identifying prognostic factors for recurrence and/or survival following surgical excision of metastases to these sites.
Subject(s)
Breast Neoplasms/pathology , Liver Neoplasms/secondary , Liver Neoplasms/surgery , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Female , Humans , PrognosisABSTRACT
OBJECTIVE: Portal hypertension is characterized by hyperdynamic splanchnic circulation associated with the development of portosystemic portal collateral circulation. Since blood flow regulation mechanisms in the splanchnic organs can be metabolic, its metabolic capacity has been studied using the mitochondrial enzyme cytochrome C oxidase as histochemical marker. METHOD: Cytochrome oxidase was quantified with a histochemical technique in the liver, pancreas and small bowel of Wistar rats in the control group (n = 8) and in rats with portal hypertension by triple stenosing ligation of the portal vein (n = 9) at 28 days of evolution. RESULTS: All rats with portal hypertension develop portosystemic collateral circulation. In these animals, cytochrome oxidase activity increases (p < 0.01) in the liver (left lateral lobe, periportal zone: 91.81 +/- 5.18 vs. 86.03 +/- 2.82) exocrine pancreas (125.6 +/- 7.25 vs 117.57 +/- 6.43; p < 0.05) as well as in the mucosa (crypts) and duodenum serosa, jejunum and ileum while it decreases in the pericentral zone of the hepatic acinus and intestinal villi. CONCLUSION: Cytochrome oxidase is considered an endogenous marker of local tissular metabolic capacity, so that its increased activity in the small bowel mucosa, crypts, exocrine pancreas and visceral peritoneum may be a metabolic factor that induces splanchnic hyperdynamic circulation in short-term portal hypertensive rats.
