ABSTRACT
We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group.
Subject(s)
Interleukin-1/blood , Interleukin-6/blood , Nephrotic Syndrome/metabolism , Tumor Necrosis Factors/blood , beta 2-Microglobulin/urine , Analysis of Variance , Blood Urea Nitrogen , Case-Control Studies , Chi-Square Distribution , Child , Child, Preschool , Egypt , Female , Hemoglobins/metabolism , Hospitals, Pediatric , Hospitals, University , Humans , Interleukin-1/immunology , Interleukin-6/immunology , Leukocyte Count , Male , Nephrotic Syndrome/diagnosis , Nephrotic Syndrome/drug therapy , Nephrotic Syndrome/immunology , Predictive Value of Tests , Recurrence , Remission Induction , Serum Albumin/metabolism , Treatment Outcome , Tumor Necrosis Factors/immunology , beta 2-Microglobulin/immunologyABSTRACT
We studied 60 children affected with idiopathic nephrotic syndrome [INS] plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin [IL]-1beta, IL-6, tumour necrosis factor [TNF] and quantitative urinary beta-2-microglobulin [beta-2-m] excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively [100%] the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively [100%] the control group
