ABSTRACT
Introducción: El uso de la punción-aspiración con aguja fina (PAAF) junto con la citometría de flujo (CMF) constituye una alternativa diagnóstica frente a la biopsia. Objetivos: Se compara la eficacia diagnóstica de la citología más CMF en enfermedades linfoproliferativas y se calcula el coste de la PAAF frente a la biopsia. Resultados: La sensibilidad de la CCF es del 96 por ciento en procesos reactivos y la especificidad del 97 por ciento. En el diagnóstico de los linfomas no Hodgkin, teniendo en cuenta el tipo, la sensibilidad es del 89 por ciento, la especificidad del 100 por ciento y la eficacia del 95 por ciento. La citología unida a la CMF resulta cuatro veces más barata que la biopsia. Conclusiones: Las técnicas de CMF e inmunocitoquímica para aplicar a las PAAF son aconsejables en determinados casos por su rapidez, economía, menor morbilidad y menores molestias para el paciente. Otra perspectiva a considerar es la aplicación de técnicas de biología molecular (AU)
Subject(s)
Adolescent , Adult , Aged , Female , Male , Middle Aged , Humans , Biopsy, Needle , Sensitivity and Specificity , Immunohistochemistry/methods , Molecular Biology/methods , Ganglia/cytology , Ganglia , Ganglia/ultrastructure , Ganglia/pathology , Lymph Nodes/physiopathology , Lymph Nodes/pathology , Tomography, Emission-Computed/methods , Ultrasonography/methods , Flow Cytometry/methods , Flow Cytometry , Lymphoma/diagnosis , Lymphoma/pathology , Lymphoma/economics , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/pathology , Lymphoma, Non-Hodgkin , Lymphoma, Non-Hodgkin/ultrastructure , Lymphoma, Non-Hodgkin/economics , Biopsy/methods , Biopsy , Antibodies/analysis , Antibodies , Antigens, CD19 , CD3 Complex , CD4 Antigens , CD8 Antigens , Antigens, CD20 , CD5 Antigens , Receptors, IgE/analysis , CD56 Antigen/analysis , Receptors, IgG/analysis , Antigens, CD7 , CD2 Antigens , Receptors, Interleukin-2/analysis , Neprilysin , Indicators and Reagents/analysisABSTRACT
At present the utilization of quantitative techniques in anatomopathological studies is becoming more and more frequent, so adding the possibility of gaining measures and numerical assessments in front of conventional quantitative evaluations. In the paper the AA. report their first attempt with conventional slides of epidermoid carcinomas of the larynx, taken from the files. The aim has been to check out the contribution of this procedure compared with other traditional pathological techniques.
Subject(s)
Carcinoma, Squamous Cell/pathology , Densitometry/methods , Diagnostic Imaging/standards , Laryngeal Neoplasms/pathology , Larynx/pathology , Carcinoma, Squamous Cell/ultrastructure , Cell Count , Cell Movement , Densitometry/statistics & numerical data , Hematoxylin , Humans , Laryngeal Neoplasms/ultrastructure , Larynx/ultrastructure , Reproducibility of ResultsABSTRACT
By multiple linear regression the authors show a closed relationship between survival and conventional anatomopathologic data as grade of differentiation and of lymphoid infiltration of the primary tumor. This retrospective pathological study showed that various degrees of squamous cell differentiation may be recognized for malignant laryngeal lesions and that such distinction may be of prognostic significance.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Lymphocytes, Tumor-Infiltrating , Carcinoma, Squamous Cell/mortality , Humans , Laryngeal Neoplasms/mortality , Prognosis , Regression Analysis , Survival AnalysisABSTRACT
Microvascular invasion by carcinoma cells is one of the first steps for the potential development of metástasis. The presence of squamous cell carcinoma within capillaries and/or venules in the immediate vicinity of primary lesions of the oral cavity and oropharynx may be related to regional lymph node metastasis. To evaluate this possibility in laryngeal carcinomas we have reviewed the histopathologic features of 48 cases of this type of tumor with simultaneous surgical treatment of the primary neoplasms and the neck. In our opinion the histologic finding of such invasion is not pathognomonic for establishment of regional metástasis in epidermoid carcinoma of the larynx.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Neoplastic Cells, Circulating/pathology , Humans , Neoplasm InvasivenessABSTRACT
Histologic specimens from 75 patients with squamous cell carcinoma of the larynx treated exclusively by surgery were studied with special attention paid to the growth of the tumor in relation with the different laryngeal compartments. Some aspects traditionally admitted are discussed. The result show a not very close relation between the classic anatomic descriptions and the tumoral growing.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Larynx/anatomy & histology , Epiglottis , Glottis , Humans , Laryngeal Cartilages/pathology , Ligaments/pathology , Neoplasm InvasivenessABSTRACT
Histologic specimens from 48 patients with squamous cell carcinoma of the larynx treated exclusively by surgery were studied with special attention paid to the reactivity of regional lymph nodes. The lymph nodes were classified into four microscopic patterns of immune response: lymphocytic predominance, sinus histiocytosis, germinal center predominance and unstimulated or lymphocytic depletion. As a result no correlation were then made between the patterns and survival rate at 5 year follow-up.
Subject(s)
Carcinoma, Squamous Cell/mortality , Laryngeal Neoplasms/mortality , Lymph Nodes/pathology , Carcinoma, Squamous Cell/immunology , Humans , Laryngeal Neoplasms/immunology , PrognosisABSTRACT
At the moment the use of quantitative techniques in anatomopathology is more and more frequent. In this study the authors use for the first time the morpho-photometry approach in epidermoid carcinomas of the larynx coming from filed material. In this way they are checking if this method adds anything to conventional anatomopathology.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Photometry/methods , Cell Nucleus/pathology , Humans , Larynx/pathology , Photometry/instrumentationABSTRACT
At the moment the use of quantitative techniques is not very frequent in standard anatomopathologic studies of epidermoid carcinoma of the larynx. By "multiple linear regression" the authors show a closed relationship between survival and conventional anatomopathologic data as grade of differentiation and of lymphoid infiltration of the primary tumor.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/mortality , Humans , Laryngeal Neoplasms/epidemiology , Laryngeal Neoplasms/mortality , Larynx/pathology , Lymphatic Metastasis , Prognosis , Regression AnalysisABSTRACT
At the present application of quantitative techniques in anatomopathologic studies is becoming more and more frequent, adding the possibility of numeric and quantitative evaluation. In this study the authors make a first attempt with one of these methods, the image analysis using conventional slides of epidermoid carcinomas from larynx.
Subject(s)
Carcinoma, Squamous Cell/pathology , Image Processing, Computer-Assisted , Laryngeal Neoplasms/pathology , Histological Techniques , HumansABSTRACT
At the moment the use of quantitative techniques in anatomopathology are becoming more and more frequent. In this study, with the mathematical transformation of morphometric data obtained from cell populations of epidermoid carcinoma of the larynx, the authors arrive at the "grade of malignancy" for every patient which has in itself prognostic value without taking into account the other anatomopathologic or clinical parameters.
Subject(s)
Carcinoma, Squamous Cell/pathology , Cytophotometry , Laryngeal Neoplasms/pathology , Aneuploidy , Carcinoma, Squamous Cell/mortality , Cell Differentiation , Cell Nucleus/ultrastructure , DNA, Neoplasm/analysis , Humans , Laryngeal Neoplasms/mortality , Prognosis , Retrospective StudiesABSTRACT
The use of morpho-photometric techniques in anatomopathology is, on the whole, not very frequent at the moment. In this study the authors show the possible applications of these quantitative methods for the evaluation of kinetics characteristics of cell population in epidermoid carcinomas of the larynx.
Subject(s)
Carcinoma, Squamous Cell/pathology , Cytological Techniques , Laryngeal Neoplasms/pathology , Photometry , Aneuploidy , Cell Division , Humans , Kinetics , Models, BiologicalABSTRACT
The anatomopathologic study of epidermoid carcinoma of the larynx is a reason for many publications in the international scientific community in spite of the apparent histologic similarity of this type of tumor. After a careful review from wide material the authors make reference to the prognostic value of certain anatomopathologic finding.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Adult , Aged , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/therapy , Combined Modality Therapy , Humans , Laryngeal Neoplasms/epidemiology , Laryngeal Neoplasms/mortality , Laryngeal Neoplasms/therapy , Laryngectomy/statistics & numerical data , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Staging , Prognosis , Spain/epidemiologyABSTRACT
Epithelioid granuloma is not the typical antitumors reaction of the lymph nodes in head and neck area. In this study the authors look at and consider this subject in relation with tumors in the larynx.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Lymphadenitis/pathology , Carcinoma, Squamous Cell/surgery , Granuloma/pathology , Humans , Laryngeal Neoplasms/surgery , Laryngectomy , Larynx/pathology , Lymph Nodes/pathology , Lymphatic Metastasis , Male , Middle Aged , NecrosisABSTRACT
The relationship between laryngocele and laryngeal carcinoma has already been well established. A distinct entity is the carcinoma arising from the ventricular saccule or a preexisting laryngocele showing a peculiar clinical behavior and pathological features. We present here a case of ventriculosaccular carcinoma of the larynx, discussing the clinical presentation and the immunohistochemical analysis performed using monoclonal antibodies, and the factors which might modulate the aggressiveness of the neoplasm.
Subject(s)
Carcinoma, Squamous Cell/pathology , Laryngeal Neoplasms/pathology , Larynx/abnormalities , Antigens, Neoplasm/analysis , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/surgery , HLA-DR Antigens/analysis , Humans , Inflammation , Laryngeal Neoplasms/etiology , Laryngeal Neoplasms/surgery , Larynx/pathology , Male , Middle Aged , T-Lymphocyte SubsetsABSTRACT
The proportion of granulocytes, erythroblasts, immature cells and megakaryocytes was evaluated when revising the bone-marrow biopsy specimens of 36 patients with myeloproliferative syndromes. These proportions were compared between themselves, a so-called Z value being thus attained; such value resulted from summing the proportion of granulocytes, megakaryocytes and immature cells and subtracting the proportion of erythroblasts. According to its value, above or below the mean, the Z figure correlates with the survival, the difference between both groups appearing as statistically significant (p = 0.02).
Subject(s)
Bone Marrow Examination , Bone Marrow/pathology , Myeloproliferative Disorders/pathology , Biopsy , Cell Count , Evaluation Studies as Topic , Humans , Life Tables , Myeloproliferative Disorders/mortality , Prognosis , Spain/epidemiology , Survival RateABSTRACT
We report a case of airway obstruction in an adult patient due to a lymphoid polyp of the palatine tonsil. We discuss some aspects of etiopathogenesis and differential diagnosis of this uncommon tumour.