Fase final de la validación transcultural al español de la escala Hair Specific Skindex-29: sensibilidad al cambio y correlación con la escala SF-12 / Final Phase in the Validation of the Cross-Cultural Adaptation of the Hair-Specific Skindex-29 Questionnaire Into Spanish: Sensitivity to Change and Correlation With the 12-Item Short-Form Health Survey

Antecedentes y objetivo: Previamente se había iniciado el proceso metodológico para la validación transcultural al idioma español de la escala Hair Specific Skindex-29 (HSS-29), que mide el impacto de la alopecia androgénica femenina sobre la calidad de vida relacionada con la salud (CVRS). Para finalizar el proceso, el objetivo del estudio fue completar la validación a través de la determinación de su sensibilidad al cambio y su correlación con una escala generalista de CVRS (SF-12). Material y método: Se establecieron dos visitas, una basal y otra tras 6meses de tratamiento con suplemento alimenticio con actividad inhibidora de la enzima 5-alfa reductasa. En cada visita, investigadores y pacientes valoraron la gravedad de la alopecia mediante la escala Sinclair, el estado de la apariencia del cabello, y se administraron las escalas HSS-29 y SF-12. Resultados: Participaron 983 mujeres con alopecia androgénica. La media de puntuación en la escala HSS-29 cambió de 27,5 ± 18,7 en la visita basal a 19,3 ± 15,7 en la de seguimiento, y sus dimensiones funcional, emocional y sintomática también cambiaron significativamente. Tanto las diferencias entre basal y seguimiento en el índice HSS-29 global como en cada una de sus dimensiones se correlacionaron significativamente con las diferencias encontradas en las dimensiones de SF-12. Los coeficientes de correlación de Pearson oscilaron entre -0,1 y -0,4, y en todos los casos el grado de significación fue p < 0,001. Conclusiones: La versión en español de la escala HSS-29 posee sensibilidad, es decir, detecta cambios relacionados con la calidad de vida cuando las condiciones objetivas varían. Igualmente, se observó una correlación entre las escalas HSS-29 y SF-12

Background and objective: Work has already been done on validating the cross-cultural adaptation of the Hair-Specific Skindex-29 questionnaire (HSS-29) into Spanish. This questionnaire measures the impact of female-pattern hair loss on health-related quality of life (HRQoL). The aim of this study was to complete the validation process by testing the questionnaire's sensitivity to change and assessing its correlation with the generic 12-item Short-Form Health Survey (SF-12). Material and method: Patients who started treatment with a nutritional supplement that blocks the activity of 5-alpha-reductase were seen in two visits: a baseline visit and a follow-up visit at 6months. At each visit, hair loss severity was assessed by both investigators and patients via the Sinclair scale, evaluation of hair condition, and administration of HSS-29 and SF-12. Results: In total, 983 women with female-pattern hair loss participated in the study. The mean HSS-29 score decreased from 25.7 ± 18.7 at baseline to 19.3 ± 15.7 at follow-up and significant changes were also observed in the functioning, emotions, and symptoms domains. Changes in overall and subscale HSS-29 scores from baseline to follow-up were all significantly correlated with changes in SF-12 subscale scores. The Pearson correlation coefficients ranged from -0.1 to -0.4 and were all significant at P <.001. Conclusions: The Spanish version of HSS-29 is sensitive to change, as it detected changes in objective measurements of HRQoL. Correlations between HSS-29 and SF-12 scores were also observed

Final Phase in the Validation of the Cross-Cultural Adaptation of the Hair-Specific Skindex-29 Questionnaire Into Spanish: Sensitivity to Change and Correlation With the 12-Item Short-Form Health Survey. / Fase final de la validación transcultural al español de la escala Hair Specific Skindex-29: sensibilidad al cambio y correlación con la escala SF-12.

BACKGROUND AND OBJECTIVE: Work has already been done on validating the cross-cultural adaptation of the Hair-Specific Skindex-29 questionnaire (HSS-29) into Spanish. This questionnaire measures the impact of female-pattern hair loss on health-related quality of life (HRQoL). The aim of this study was to complete the validation process by testing the questionnaire's sensitivity to change and assessing its correlation with the generic 12-item Short-Form Health Survey (SF-12). MATERIAL AND METHOD: Patients who started treatment with a nutritional supplement that blocks the activity of 5-alpha-reductase were seen in two visits: a baseline visit and a follow-up visit at 6months. At each visit, hair loss severity was assessed by both investigators and patients via the Sinclair scale, evaluation of hair condition, and administration of HSS-29 and SF-12. RESULTS: In total, 983 women with female-pattern hair loss participated in the study. The mean HSS-29 score decreased from 25.7±18.7 at baseline to 19.3±15.7 at follow-up and significant changes were also observed in the functioning, emotions, and symptoms domains. Changes in overall and subscale HSS-29 scores from baseline to follow-up were all significantly correlated with changes in SF-12 subscale scores. The Pearson correlation coefficients ranged from -0.1 to -0.4 and were all significant at P<.001. CONCLUSIONS: The Spanish version of HSS-29 is sensitive to change, as it detected changes in objective measurements of HRQoL. Correlations between HSS-29 and SF-12 scores were also observed.

[Trichothiodystrophy: PIBIDS syndrome]. / Tricotiodistrofia: síndrome PIBIDS.

Trichothiodystrophy comprises a heterogeneous group of autosomal recessive entities. This fact gives rise to different interrelated neuroectodermal disorders. From a structural point of view these features are the result of the low tissue sulfur content. We report a case of trichothiodystrophy initially classified as Tay syndrome that based on clinical features, complementary exams as well as on the disease evolution was labelled as PIBIDS syndrome.

Tricotiodistrofia: síndrome PIBIDS / Trichothiodystrophy: PIBIDS syndrome

La tricotiodistrofia conforma un grupo heterogéneo de entidades determinadas genéticamente por un patrón autosómico recesivo. Este hecho va a dar lugar a diferentes alteraciones que comparten un mismo origen neuroectodérmico. Desde el punto de vista estructural estas manifestaciones se caracterizan por ser consecuencia del bajo contenido de azufre tisular. Presentamos un caso de tricotiodistrofia clasificado inicialmente como síndrome Tay, pero en función de las manifestaciones clínicas y pruebas complementarias, así como de la evolución de la enfermedad, fue finalmente etiquetado como síndrome PIBIDS

Trichothiodystrophy comprises a heterogeneous group of autosomal recessive entities. This fact gives rise to different interrelated neuroectodermal disorders. From a structural point of view these features are the result of the low tissue sulfur content. We report a case of trichothiodystrophy initially classified as Tay syndrome that based on clinical features, complementary exams as well as on the disease evolution was labelled as PIBIDS syndrome

Alopecias: orientación diagnóstica, clínica y terapéutica

Se llama alopecia a cualquier tipo de caída o pérdida de pelo. Esta entidad, aun siendo clínicamente benigna, es una alteración importante por su frecuencia, por ser origen de conflictos emocionales y porque, a veces, es un signo de otras alteraciones orgánicas. Con fines diagnósticos es útil dividir las alopecias en cicatriciales y no cicatriciales. Dentro de las primeras, las más frecuentes son las que acompañan a dermatosis inflamatorias crónicas, en especial el lupus eritematoso discoide y el liquen plano pilar. Entre las segundas están sin duda las alopecias más frecuentes de todas: la alopecia telogénica, la calvicie común y la alopecia areata. El conocimiento de sus manifestaciones clínicas, la anamnesis y la exploración tricológica, nos permitirán hacer un diagnóstico correcto y aplicar un tratamiento adecuado en cada caso (AU)