Osteonecrosis de los maxilares por bisfosfonatos. Actualización y puesta al día / Bisphosphonate-related osteonecrosis of the jaws. An update

Los bisfosfonatos son unos fármacos ampliamenteutilizados principalmente para la osteoporosis y tambiénen oncología. Un efecto secundario o complicación delos mismos, desconocida hasta el año 2003, es la osteonecrosisde los maxilares. Se revisan, en este trabajo, lascaracterísticas químicas de los distintos bisfosfonatos,su posible mecanismo de acción, la potencia relativa, losproductos comerciales existentes en el mercado farmacéuticoespañol y sus indicaciones; igualmente se repasala osteonecrosis de los maxilares en sus comienzos, suconcepto, sus estadios clínicos, la razón por la que estapatología aparece en los maxilares, sus factores de riesgo,su incidencia, la actitud a tomar por los dentistas conlos pacientes que toman bisfosfonatos, el tratamiento yla posible predicción de la osteonecrosis(AU)

Bisphosphonates are widely used drugs, primarilyfor osteoporosis and also in oncology. A drug-inducedside effect or complication, which only recently cameto light in 2003, is osteonecrosis of the jaw. This studyreviews the chemical characteristics of the variousbisphosphonates, their possible mechanism of action,relative potency, the commercial products available onthe spanish pharmaceutical market and the indicationsfor bisphosphonate treatment. The study also considersosteonecrosis of the jaw with regard to its onset,concept, clinical stages, why this pathology affects thejaws, its risk factors, incidence, the attitude to be adoptedby dentists with patients taking bisphosphonates, aquick review of the treatment and the possible predictionof osteonecrosis(AU)

[Bisphosphonate-related osteonecrosis of the jaws. An update]. / Osteonecrosis de los maxilares por bisfosfonatos. Actualización y puesta al día.

Bisphosphonates are widely used drugs, primarily for osteoporosis and also in oncology. A drug-induced side effect or complication, which only recently came to light in 2003, is osteonecrosis of the jaw. This study reviews the chemical characteristics of the various bisphosphonates, their possible mechanism of action, relative potency, the commercial products available on the spanish pharmaceutical market and the indications for bisphosphonate treatment. The study also considers osteonecrosis of the jaw with regard to its onset, concept, clinical stages, why this pathology affects the jaws, its risk factors, incidence, the attitude to be adopted by dentists with patients taking bisphosphonates, a quick review of the treatment and the possible prediction of osteonecrosis.

Causas de exodoncia en el servicio navarro de Salud-Osasunbidea: estudio epidemiológico / Causes of exodontia in the navarra health Service-Osasunbidea: epidemiological study

El objetivo del presente trabajo es dar a conocer las causas de las extracciones dentales en el Servicio Navarro de Salud-Osasunbidea (SNS-O). Durante 6 meses se registraron todas las extracciones dentales realizadas en las consultas de Odontología del SNS-O en Pamplona. Se registraron datos por cada extracción realizada. Se anotó la edad y sexo del paciente, el diente extraído y la causa de la exodoncia. Las causas que se consideraron fueron: periodoncia, caries, mixta, ortodoncia, fractura y otras. Se realizaron 4.259 extracciones; el 62,1 por ciento se efectuaron en hombres y el 37,9 por ciento en mujeres (proporción diferente de la población general, p < 0,0001). La edad media fue 53,14 años (DE = 16,77 años; IC 95 por ciento: 52,62 a 53,66 años). Se extrajeron por caries el 49,9 por ciento, por causas periodontales el 33,7 por ciento, por causas mixtas el 3,6 por ciento, por ortodoncia el 1,6 por ciento, por fractura el 0,7 por ciento, por otras causas el 10,4 por ciento. Hubo diferencias estadísticamente significativas en la distribución por sexos de las exodoncias por causa periodontal (p = 0,0001), ortodoncia (p < 0,0001) y otras causas (p = 0,0009). La edad media de las exodoncias por periodoncia, acumuladas en dientes anteriores, fue mayor que por caries (p < 0,0001), acumuladas en dientes posteriores. La edad media de las exodoncias por ortodoncia fue de 20,16 años (p < 0,0001 con todas las demás causas). (AU)

[Causes of exodontia in the Navarra Health Service-Osasunbidea: epidemiological study]. / Causas de exodoncia en el Servicio Navarro de Salud-Osasunbidea: estudio epidemiológico.

The aim of this paper is to show the causes of the dental extractions in the Navarra Health Service-Osasunbidea. For 6 months all the dental extractions carried out in the clinics of the Navarra Health Service in Pamplona were registered. Data was registered for each extraction carried out. A note was made of the age and sex of the patient, the tooth extracted and the cause of the exodontia. The causes considered were: periodontia, caries, mixed causes, orthodontia, fracture and others. 4,259 extractions were carried out; 62.1% were on men and 37.9% on women (significatively different from the general population, p < 0.0001). The average age was 53.14 years (SD = 16.77 years, 95% CI: 52.62 to 53.66 years). 49.9% of extractions were due to caries, 33.7% for periodontal reasons, 3.6% for mixed causes, 1.6% for orthodontia, 0.7% because of fracture, and 10.4% for other causes. There were statistically significant differences in the distribution by sexes of the exodontias due to periodontia (p = 0.0001), orthodontia (p < 0.0001) and other causes ((p = 0.0009). The average age of the exodontias due to periodontia, accumulated in the front teeth, was greater than that for caries (p < 0.0001), accumulated in the back teeth. The average age of the exodontias due to orthodontia was 20.16 years (p < 0.0001 with all of the other causes).

Study of the influence of electroconvulsive therapy on the regional cerebral blood flow by HMPAO-SPECT.

STUDY OBJECTIVE: The aim of this preliminary study is to investigate the regional blood flow in response to ECT (electroconvulsive therapy) and to identify any responsive-pattern to the treatment. STUDY DESIGN: Single longitudinal prospective study of cohorts. SUBJECTS: For this preliminary study ten patients, female sex, mean age 70.8 years with major mood disorder (CID-10 investigation criteria) were studied after signature consent. INTERVENTIONS: The intervention consisted in the administration of bilateral brief pulse ECT three times a week, during 6 to 12 sessions according to the standards of the Psychiatric Department of the Santiago Hospital in Victoria. MEASUREMENT: Clinical evaluation of depression was evaluated by Hamilton Depression Scale, Montgomery and Asberg Scale, Newcastle Scale and regional cerebral blood flow (rCBF) using the HMPAO-SPECT. RESULTS: The pattern of distribution on the regional cerebral flow during the ECT showed changes from the basal pattern in all patients. All patients had a relative increased perfusion of the temporal lobes and basal ganglia. Other changes from the basal study were areas of decreased perfusion of the occipital lobe (6 patients) and parietal lobe (3 patients). CONCLUSIONS: Brain perfusion SPECT study of the patients with major depression shows changes during ECT. Further analysis are needed to understand the relationship between mechanisms of treatment and recovery in affective illness.

[Involuntary hospitalization in the first psychotic episodes: associated factors]. / Hospitalización contra la voluntad en primeros episodios psicóticos: factores asociados.

INTRODUCTION: The great majority of involuntary admissions at acute hospital units are related to severe psychiatric diseases. The aim of this study is to determine which are the characteristics and associated factors in first psychotic episodes not due to medical illness. METHOD: It had been evaluated, 61 first psychotic episodes hospitalised in a General Hospital Psychiatric Unit. It was used a protocol with the SCID, SCID-PANSS, DSM-IV criteria, unified clinical history, and PANSS, and Philips scales. RESULTS: 67.2% of the patients were committed to the hospital. Only the PANNS positive subscale was significantly associated with the involuntary admission. CONCLUSIONS: There is a high admission rate of involuntary inpatients with first psychotic episode. The involuntary admission is highly related to psychotic positive symptoms.

First episode in bipolar disorder: misdiagnosis and psychotic symptoms.

BACKGROUND: This study explores factors that can influence other psychotic diagnoses in the first episode of a DSM-III-R bipolar disorder. METHODS: It includes all 163 bipolar in-patients and out-patients in the state of Alava, North of Spain (Basque country) from February 1994 to May 1996. Patients were divided into two non-overlapping groups: unstable diagnoses, bipolars with an initial diagnosis of schizophrenia (or other psychosis), and stable diagnoses of bipolar disorder. RESULTS: A logistic regression analysis using marital status, age at onset and mood incongruent psychotic symptoms found that the latter was the only independent factor significantly associated with an unstable diagnosis.

[Smoking in a psychiatric population]. / Tabaquismo en población psiquiátrica.

The relationship between tobacco consumption and psychiatric disorders is a widely discussed topic that is generating a considerable yet controversial bibliography, that can be approached from different points of view. The authors make a revision and critical evaluation about smoking prevalence on psychiatric population, in the different psychiatric disorders and discussing the theories implicated.

[Predictors of rehospitalization in schizophrenia]. / Predictores de rehospitalización en la esquizofrenia.

OBJECTIVES: The aim of this study is to determine the predictive value on rehospitalization of sociodemographic variables, positive/negative symptoms and thought disorders. The results are part of research project founded by the Basque Health Department. METHODS: A 18 month follow-up study of a cohort of 60 patients with acute exacerbation of schizophrenia was carried out. The assessment was performed with DSM III-R diagnostic criteria, PANSS and CGI rating scales, and SCID-P semistructured interview. All patients received antipsychotic treatment. The sociodemographic and disease data, the dimensional score of the PANSS subscales, the score of CGI scale, the items 2, 12, 13 and 14 of the PANSS as indicators of formal thought disorders; and the items 1, 5, 6, 17 and 23 of the PANSS as content thought disorders were established as predictors. The predictive value was determined by the Cox regression test (Lee 1992). RESULTS: We did not find predictive value either in the PANSS scores or in the 9 thought disorders evaluated (Wald and RR tests were not significative). Nevertheless, considering the values of standard error obtained in the Cox regression we were not in a position to assure that they did not have an incidence in the hospitalizations. The CGI was the only scale that showed prognostic value (Wald test = 1.9945; RR = 1.7499). Our results indicated that the lower number of previous hospitalizations (Wald test = 1.1437; RR = 1.1437) and the high level of studies (Wald test = 2.4258; RR = 1.8052) diminished the risk of rehospitalization. CONCLUSIONS: 1 o The predictive value on rehospitalization for the positive/negative symptoms and thought disorders was not confirmed. 2 o CGI is the only scale with predictive value. That fact makes us consider the importance of what German psychiatrists called "smelling the schizophrenia" or "The smell of schizophrenia". 3 o Our results indicate that the lower number of previous hospitalizations, and the high level of studies diminish the risk of rehospitalization.

[Serotonergic function in endogeneity of depression]. / Función serotoninérgica y endogeneidad en la depresión.

OBJECTIVE: This study employed an alternative method for assessing serotonergic function in depression. The neuroendocrine responses to acute intravenous administration of the serotonin (5-HT) reuptake inhibitor clomipramine were assessed in patients with Major Depression with Melancholia (DMM) and matched subjects with Major Depression (DM) (without Melancholia) and Dysthimic disorder (TD). METHOD: 10 patients who met DSM III-R criteria of DMM, 10 patients with DM and 10 with DD matched for age and sex received 12.5 mg of intravenously administered clomipramine. Prl, Cortisol and GH were measured during the next 135 minutes. We divided the samples using the Newcastle Scale. RESULTS: The DMM patients had significant blunting prolactin responses to clomipramine compared with the other patients. Most of the major depression patients without melancholia were neurotic depressions according to the Newcastle Scale. There was a negative correlation between endogeneity and prolactin response. CONCLUSIONS: These data support the hypothesis that DMM patients have abnormal neuroendocrine responses to the intravenous administration of the 5-HT reuptake inhibitor clomipramine, and that there is an association between endogeneity and prolactin response.

[Positive and negative symptoms in schizophrenia: standards of change during acute exacerbation]. / Síntomas positivos y negativos en la esquizofrenia: patrones de cambio durante la exacerbación aguda.

INTRODUCTION AND OBJECTIVES: The temporal stability of the positive and negative symptoms in schizophrenia deserves a special interest due to its consequences in the outcome and the treatment of the disease. This study determines the temporal stability of positive/negative subtypes in schizophrenia during the acute phase. MATERIAL AND METHODS: This is a clinical, observational and prospective study of a dynamic cohort of patients with acute exacerbation of schizophrenia defined by DSM III-R criteria. Patients with severe and unstable organic pathology, substance dependence, mental organic disorder, mental retardation, depression, or medicamentous parkinsonism were excluded. Clinical assessment was performed with the PANSS scale. Schizophrenic subtypes were established according to inclusive and restrictive criteria of PANSS. All patients were treated with new antipsycotics and biperiden if necessary. RESULTS: 51 patients were assessed for 8 weeks. In the baseline, the negative subtype (63.3% and 52.5% by inclusive and restrictive system respectively) and paranoid form (45.1%) were predominant. Three types of analysis were performed to determine the temporal stability: 1. Concordance (Kappa index). The concordance of the inclusive and restrictive System, regarding to the baseline assessment, indicated that both criteria had a low temporal stability. 2. Mc Nemar Ji Square. This test showed that these changes were bi-directional except for the first visit, which was significant through the restrictive system (higher change from the negative to other subtypes). 3. Transition analysis among groups by First Order Morkov Chains analysis indicated that this change was stationary (the change was the same in all phases). CONCLUSIONS: 1o The variable "time" has to be considered for the definition of subtypes in schizophrenia. 2o The restrictive system is more specific. It allows to identify a subgroup of patients with "Negative" schizophrenia with a high specificity and validity in clinical and epidemiological studies. 3o The use of the baseline visit as a reference (gold standard) is recommended because it exits a higher concordance among criteria and a more florid psychopathology.

[The clomipramine test and subtypes of depression]. / El test de la clomipramina y subtipos de depresión.

OBJECTIVE: Neuroendocrine challenge paradigms have been used to assess serotonergic system in depression but limitations in the specificity of many of these tests have been noted. In this study, the neuroendocrine responses to acute intravenous administration of the serotonin (5-HT) reuptake inhibitor clomipramine were assessed in patients with Major Depression with Melancholia (DMM) and matched subjects with Major Depression (DM) (without Melancholia) and Dysthimic disorder (TD). METHOD: 10 patients who met DSM III-R criteria of DMM, 10 patients with DM and 10 with DD matched for age and sex received 12.5 mg of intravenously administered clomipramine. Prl, Cortisol and GH were measured during the next 135 minutes. RESULTS: The DMM patients had significant blunting prolactin responses to clomipramine compared with the other patients. CONCLUSIONS: These data support the hypothesis that DMM patients have abnormal neuroendocrine responses to the intravenous administration of the 5-HT reuptake inhibitor clomipramine and that they are different from the DM and TD patients.