ABSTRACT
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Subject(s)
Humans , Female , Adolescent , Antiphospholipid Syndrome/diagnosis , Chorea/etiology , Proteinuria/diagnosis , ElectroencephalographyABSTRACT
BACKGROUND: Hepatitis C virus (HCV) clearance is an independent predictive factor for long-term survival in HIV-HCV liver transplantation patients. After 46 months of antiviral therapy it is achieved in up to 80% of cases. Little is known, however, about spontaneous viral clearance. We performed prospective study of HIV-HCV coinfected liver transplant patients. METHODS: Between January 1, 2001, and December 31, 2011, we analyzed the parameters from among HIV-HCV coinfected liver transplant patients of donor and recipient ages, transplant cause, Model for End-Stage Liver Disease (MELD) score, donor and recipient serology, transplant date, viral load before and after transplantation, immunosuppressive therapy, HCV recurrence, HCV viral clearance (spontaneous and duration), retransplant cause, and viral load before and after retransplant, as well as survival. RESULTS: The seven transplanted HIV-HCV coinfected patients had most commonly HCV-related hepatocarcinoma (n = 5, 71.42%). Three subjects (42.85%) developed HCV recurrences. Two patients (28.57%) were retransplanted, both due to HCV recurrence with one of them developing a spontaneous clearance of HCV (14.28%). This patient showed a preoperative HIV viral load < 50 copies IU/mL, CD4+ count 486/µL, HCV-RNA 2564 IU copies/mL, Anti-HBc+, and MELD 30. The donor was an 81-year-old female who was Anti-HBc+. Immunosuppressive therapy consisted of cyclosporine, mycophenolate, and prednisone. One month after transplantation, the patient developed an acute cellular rejection episode with progression of liver disease secondary to the HCV recurrence (56.5 × 105 copies IU/mL). He started antiviral treatment (α-interferon and ribavirin), but due to side effects and interactions with the antiretrovirals, they were stopped after four doses. The viral load decreased spontaneously and progressively until it became negative at 146 days after transplantation; he was retransplanted and HCV-RNA has continued to be negative after 772 days. CONCLUSION: Spontaneous clearance of HCV among HIV-HCV coinfected liver transplant patients is possible. Despite no treatment, one patient still has no detectable HCV viral load after retransplantation.
Subject(s)
HIV Infections/surgery , Hepacivirus/isolation & purification , Hepatitis C/surgery , Liver Transplantation , Adult , CD4 Lymphocyte Count , HIV Infections/complications , Hepatitis C/complications , Humans , Immunosuppressive Agents/administration & dosage , Male , Middle Aged , Prospective Studies , Viral LoadABSTRACT
Introducción: Dolor crónico es aquel que permanece tras 3 meses desde la intervención quirúrgica. De etiología multifactorial, puede llegar a ser invalidante para el paciente. Objetivos: Conocer, en nuestro medio, la prevalencia del dolor crónico posthernioplastia inguinal en cirugía programada y régimen ambulatorio. Material y métodos: Estudio descriptivo retrospectivo de los pacientes diagnosticados de hernia inguinal e intervenidos de manera programada en cirugía mayor ambulatoria entre enero de 2000 y diciembre de 2006. Dolor inmediato: primeras 72 horas; dolor agudo: 3 primeros meses; dolor crónico: más de 3 meses. Seguimiento: llamada telefónica a las 24 y 48 horas del alta, revisión en consulta al mes y llamada telefónica al año. Resultados: 3.649 pacientes (81,70% hombres), edad media 54,15 años. ASA II 63,55%. Dolor inmediato en el 85% delos pacientes, que cedió con la analgesia pautada; dolor agudo en el 3%, inyectándose corticoide y anestésico local cuando el dolor no cedía pasadas 4 semanas en 3 pacientes; dolor crónico en el 0% de los pacientes seguidos durante un año. Discusión: Durante el primer mes del postoperatorio sólo están indicados analgésicos orales. Pasado este periodo y ante la permanencia de dolor, u na alternativa a la analgesia pautada puede ser la inyección de corticoide y anestésico local en lazona intervenida. Conclusión: El dolor inmediato tras la hernioplastia inguinal programada en régimen ambulatorio así como el producido en los 3 primeros meses, precisa únicamente analgesia oral. Es nula la prevalencia de dolor crónico en nuestra serie (AU)
Introduction: Chronic pain is pain that persists 3 months after the surgical procedure. Of multifactorial etiology, it can be disabling for the patient. Objetives: To determine, in our environment, the prevalence of chronic pain after inguinal hernioplasty scheduled as ambulatory surgery. Material and methods: A retrospective study of patients diagnosed with inguinal hernia and who underwent ambulatory surgery between January 2000 and December 2006. Immediate pain: at 72hours; severe pain: up to 3 months; chronic pain: more than 3months. Follow-up: telephone call at 24 and 48 hours after discharge, clinical visit one month after and phone call one year later. Results: 3,649 patients (81.70% male), mean age 54.15years. ASA II 63.55%. Immediate pain in the first 48 hours in 85% of patients, which was controlled with analgesia; severe pain in 3%, in which steroids and local anaesthetic injected in 1-2 sessions were given when the pain did not abate after 4 weeks in 3 patients; chronic pain in 0% of the patients followed for one year. Discussion: During the first month after surgery only oral analgesics are indicated. After this period and if there is persistence of pain, an alternative to analgesia may be the injection of corticosteroids and a local anaesthetic. Conclusion: The immediate pain after inguinal hernia in elective and ambulatory surgery as well as until the first 3 months require only oral analgesia. Is zero the prevalence of chronic pain in our series (AU)
Subject(s)
Humans , Hernia, Inguinal/surgery , Ambulatory Surgical Procedures/methods , Pain, Postoperative/drug therapy , Adrenal Cortex Hormones/therapeutic use , Analgesics/therapeutic use , Continuity of Patient Care/statistics & numerical dataABSTRACT
Introducción: Experiencia a corto y a largo plazo en la implantación de catéteres de diálisis peritoneal y objetivos establecidos para instaurar la técnica en régimen de cirugía mayor ambulatoria(CMA).Material y métodos: Estudio retrospectivo durante ocho años. Dos grupos: catéteres tipo Tenckhoff con dos cuff y catéteres tipo Tenckhoff con dos cuff y un lastre final. Peculiaridad quirúrgica: introducción del catéter en una solución antibiótica. Las complicaciones se han dividido en corto y largo plazo en función de que aparecieran o no en la primera semana de implantación. Resultados: Causa más frecuente conocida de insuficiencia renal crónica: diabetes mellitus (9,8%). En el 33,1% (41 catéteres)no hubo ninguna complicación, y destacan el dolor a corto plazo(8,9%) y la peritonitis a largo plazo (8,1%). El 78,4% de los inicialmente implantados no precisaron ser recambiados. Conclusiones: La colocación del catéter peritoneal debe ser realizada en quirófano. La diálisis peritoneal es una técnica segura, eficaz y simple tanto para el cirujano como para el paciente. Presenta escasas complicaciones, fundamentalmente dolor y peritonitis. El catéter se recambia cuando funciona mal o fuga. No existen en la literatura estudios que reflejen la introducción del catéter en una solución antibiótica previo a su colocación. Puede implantarse en régimen de CMA (AU)
Introduction: Our short and long term experience in the implantation of peritoneal catheters is exposed in this study and whether the aims established for ambulatory surgery are fulfilled. Material and methods: An eight year retrospective study. Two groups: catheters type Tenckhoff with two cuffs and catheters type Tenckhoff with two cuffs and a ballast on the end. Surgical peculiarity: the introduction of the catheter in an antibiotic solution. The complications were divided in short and long term depending on when they appeared during the first week of implantation or not. Results: The most frequent reason for chronic renal insufficiency was: diabetes mellitus (9.8%). In 33.1% of cases (41catheters) there were no complications, and only pain on the short-term (8.9%) and peritonitis on the long-term (8.1%).78.43% of the initially implanted catheters did not need to be replaced. Conclusions: The placement of the peritoneal catheter must be done in the operating room.Peritoneal dialysis is a sure, effective and simple technique for the surgeon and for the patient. It presents few complications,mainly pain and peritonitis. The catheter is replaced when it works badly or leaks. There are no studies in the literature that reflectthe introduction of the catheter in an antibiotic solution before its placement. It can be implanted as an AS procedure (AU)
Subject(s)
Humans , Peritoneal Dialysis/methods , Ambulatory Surgical Procedures/methods , Retrospective Studies , Catheter-Related Infections/prevention & controlSubject(s)
Bile , Liver Diseases/diagnosis , Liver Diseases/surgery , Liver/injuries , Wounds, Nonpenetrating/complications , Adult , Drainage , Humans , Liver Diseases/etiology , MaleABSTRACT
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