ABSTRACT
Resumen Clostridium spp. es un bacilo grampositivos, anaerobio, formador de esporas y ampliamente distribuido en el ambiente. Las infecciones por Clostridium perfringens en neonatos son en extremo raras. La sepsis grave por anaerobios, incluyendo el choque séptico, es un evento clínico inusual en este grupo de pacientes. Se reportan dos casos de bacteriemia por C. perfringens asociados a choque séptico fulminante en recién nacidos con enterocolitis necrosante grave.
Abstract Clostridium species are anaerobic, spore, forming gram-positive bacteria that are widely spread in the environment. Clostridium perfringens infections in neonates are extremely rare. Severe anaerobic sepsis, including septic shock, is an unusual clinical event in this group of patients. We highlight two cases of C. perfringens bacteremia associated with fulminant septic shock in neonates with severe necrotizing enterocolitis.
ABSTRACT
Bloodstream infection (BSI) is one of the main causes of sepsis and death in newborns. The relative importance of nosocomial and non-nosocomial agents in developing countries is not clear. We conducted a prospective study of newborns hospitalized with a first episode of BSI in order to classify it as early, late or nosocomial, describe the clinical and microbiological charateristics, and explore risk factors between hospital-acquired vs commu-nity-acquiered BSI (HA-BSI vs CA-BSI). Twenty-seven newborns with a first episode of BSI were identified. Streptococcus agalactiae and coagulase negative Staphylococcus were the main agents in CA-BSI and HA-BSI, respectively. The only significant intrinsic risk factor between HA-BSI and CA-BSI was gestational age. The frequent finding of S. agalactiae warrants routine screening and prophylaxis in pregnant women. The risk factors for HA-BSI were mostly extrinsic, and thus, susceptible of being modified.
La infección del torrente circulatorio (ITC) es una de las principales causas de sepsis y muerte neonatal. Su etiología en países en vía de desarrollo, entre agentes no nosocomiales vs nosocomiales no está suficientemente esclarecida. Estudio prospectivo que incluyó neonatos hospitalizados que presentaron un primer hemocultivo positivo, con el propósito de describir características clínicas, microbiológicas, clasificar la ITC en temprana, tardía y nosocomial, y explorar factores de riesgo entre ITC adquirida en la comunidad vs ITC adquirida en el hospital (ITC-AC vs ITC-AH). Se identificaron 27 neonatos con un primer episodio de ITC. Streptococcus agalactiae y Staphylococcus coagulasa negativa fueron los principales agentes en ITC-AC e ITC-AH, respectivamente. El factor de riesgo intrínseco que mostró una diferencia significativa entre ITC-AC vs. ITC-AH fue la edad gestacional. La presencia de S. agalactiae permite plantear el tamizaje y profilaxis a la gestante. Los factores de riesgo para ITC-AH fueron en su mayoría extrínsecos, es decir, susceptibles de ser modificados.
Subject(s)
Female , Humans , Infant, Newborn , Male , Bacteremia/epidemiology , Community-Acquired Infections/epidemiology , Cross Infection/epidemiology , Gram-Negative Bacterial Infections/epidemiology , Gram-Positive Bacterial Infections/epidemiology , Bacteremia/microbiology , Colombia/epidemiology , Community-Acquired Infections/microbiology , Cross Infection/microbiology , Gram-Negative Bacterial Infections/microbiology , Gram-Positive Bacterial Infections/microbiology , Neonatology , Prospective Studies , Risk FactorsABSTRACT
Bloodstream infection (BSI) is one of the main causes of sepsis and death in newborns. The relative importance of nosocomial and non-nosocomial agents in developing countries is not clear. We conducted a prospective study of newborns hospitalized with a first episode of BSI in order to classify it as early, late or nosocomial, describe the clinical and microbiological characteristics, and explore risk factors between hospital-acquired vs community-acquired BSI (HA-BSI vs CA-BSI). Twenty-seven newborns with a first episode of BSI were identified. Streptococcus agalactiae and coagulase negative Staphylococcus were the main agents in CA-BSI and HA-BSI, respectively. The only significant intrinsic risk factor between HA-BSI and CA-BSI was gestational age. The frequent finding of S. agalactiae warrants routine screening and prophylaxis in pregnant women. The risk factors for HA-BSI were mostly extrinsic, and thus, susceptible of being modified.