ABSTRACT
El tumor miofibroblástico inflamatorio es una enfermedad poco frecuente en la edad pediátrica, en general benigna, aunque con posible evolución a malignidad. Se presentan 3 pacientes con tumor miofibroblástico en edad pediátrica, en diferentes localizaciones: pulmonar, gástrica e intestinal. Las características clínicas dependen del lugar en el que esté ubicado el tumor. Generalmente, hay fiebre prolongada en todos, sin gran afectación del estado general. En el primer caso, la hematemesis era su primer síntoma, mientras que en el segundo la anemia y la fiebre obligaron a la realización de una imagen abdominal. En el tercer caso fueron la fiebre, la tos y los síntomas respiratorios los que alertaban acerca de una posible tumoración pulmonar. En este caso se obtuvo un cultivo positivo para una micobacteria atípica: Mycobacterium avium. Todos los casos cursan con aumento de proteína C reactiva, velocidad de sedimentación globular, anemia, trombocitosis y aumento de gammaglobulinas. La evolución es favorable; la cirugía es curativa siempre y cuando la resección sea total; el diagnóstico es anatomopatológico. Los autores quieren destacar la precocidad en el diagnóstico de uno de los pacientes (3 meses), dato no hallado en la literatura médica (AU)
There cases of paediatric inflammatory myofibroblastic tumours in different locations are presented. This a rare benign disease, that can develop into malignant forms. Clinical features are associated with the location. Fever was the main symptom in all our cases. The symptoms that indicated the location of the tumour were, haematemesis in the first case, and respiratory disease in the third. ,In the third case our patient was diagnosed with tuberculosis due to mycobacterium avium. All cases had increased CRP, ESR, thrombocytosis and high levels of gamma globulins. Surgery is curative if total resection is possible, and the diagnosis is made by histopathology. We would like to emphasise the early development in the second case as this was a 3 months-old infant (AU)
Subject(s)
Humans , Male , Female , Infant , Child , Neoplasms, Muscle Tissue/diagnosis , Mycobacterium avium/isolation & purification , C-Reactive Protein/analysis , Anemia/diagnosis , Thrombocytosis/diagnosis , gamma-GlobulinsSubject(s)
Humans , Male , Child, Preschool , Thyroiditis, Suppurative/diagnosis , Actinomyces/pathogenicity , Abscess/etiologyABSTRACT
Objetivos: Realizar el estudio antropométrico longitudinal de una cohorte de niños sanos así como un análisis comparativo con los estudios españoles más cualificados (M. Hernández et al, L. Serra-Majem et al y A. Carrascosa et al). Material y métodos: Se registraron retrospectivamente el peso, la talla y el índice de masa corporal (IMC) al nacimiento y a las edades de 1, 2, 3, 4, 6, 8, 10, 12 y 14 años, en una cohorte de niños nacidos en el año 1993 y residentes en Navarra hasta el año 2007. La muestra estaba compuesta por 930 sujetos sanos (482 varones y 448 mujeres), de raza caucásica e hijos de padres de origen español. Resultados: Se exponen los valores medios de tallas, pesos e IMC con su distribución percentilada en ambos sexos. Respecto a las tablas de M. Hernández, se observaron algunas diferencias que se incrementaron significativamente con la edad. A la edad de 14 años, la talla y el peso (P50) de los varones navarros era superior en 5,8cm y 9,0kg, y la talla y el peso de las mujeres navarras en 4,2cm y 3,6kg, respectivamente. Al comparar los datos obtenidos con las tablas de L. Serra-Majem y de A. Carrascosa, no se observaron diferencias significativas. Conclusiones: Se corrobora una aceleración secular de talla y peso. A pesar del diseño longitudinal del presente trabajo, los datos obtenidos son superponibles a los valores antropométricos actualizados de la población pediátrica española, lo que permite considerar que en Navarra se haya alcanzado una estabilización definitiva del crecimiento en relación con sus circunstancias socioeconómicas y sanitarias favorables (AU)
Objectives: To perform a longitudinal study of anthropometric measurements in a cohort of healthy children, and a comparative analysis with one of the most accepted Spanish studies (M. Hernández et al, L. Serra-Majem et al and A. Carrascosa et al). Material and methods: Weight, height and body mass index (BMI) at birth and age 1, 2, 3, 4, 6, 8, 10, 12 and 14 years were recorded. The cohort was made up of children born in 1993 and living in Navarre until 2007. The sample consisted of 930 healthy Caucasian children (482 males and 448 females) whose parents were of Spanish origin. Results: Mean values of height, weight and BMI with percent distribution in both sexes are shown. Differences that increased significantly with age were observed when compared to the tables of M. Hernández et al. Height and weight values (50 percentile) for males in Navarre were 5.8cm and 9.0kg higher, respectively, and for females 4.2cm and 3.6kg higher, respectively, at age 14. Differences were not significant when these data were compared to the tables of L. Serra-Majem and A. Carrascosa. Conclusions: An increase in weight and height is corroborated. Despite the longitudinal design of this study, the data obtained is similar to the current anthropometric measurements of the Spanish paediatric population. This means that a definitive stabilization in growth may have been reached due to the favourable socioeconomic and health conditions (AU)
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Growth , Body Weights and Measures , Anthropometry , Body Mass Index , Longitudinal StudiesABSTRACT
OBJECTIVES: To perform a longitudinal study of anthropometric measurements in a cohort of healthy children, and a comparative analysis with one of the most accepted Spanish studies (M. Hernández et al, L. Serra-Majem et al and A. Carrascosa et al). MATERIAL AND METHODS: Weight, height and body mass index (BMI) at birth and age 1, 2, 3, 4, 6, 8, 10, 12 and 14 years were recorded. The cohort was made up of children born in 1993 and living in Navarre until 2007. The sample consisted of 930 healthy Caucasian children (482 males and 448 females) whose parents were of Spanish origin. RESULTS: Mean values of height, weight and BMI with percent distribution in both sexes are shown. Differences that increased significantly with age were observed when compared to the tables of M. Hernández et al. Height and weight values (50 percentile) for males in Navarre were 5.8 cm and 9.0 kg higher, respectively, and for females 4.2 cm and 3.6 kg higher, respectively, at age 14. Differences were not significant when these data were compared to the tables of L. Serra-Majem and A. Carrascosa. CONCLUSIONS: An increase in weight and height is corroborated. Despite the longitudinal design of this study, the data obtained is similar to the current anthropometric measurements of the Spanish paediatric population. This means that a definitive stabilization in growth may have been reached due to the favourable socioeconomic and health conditions.
Subject(s)
Body Height , Body Mass Index , Body Weight , Child Development , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Longitudinal Studies , Male , Reference Values , SpainABSTRACT
AIM: To analyse the epidemiological characteristics and the relative distribution of the different types of epilepsy and epileptic syndromes during the first year of life. PATIENTS AND METHODS: An analysis was performed of the patient records of all patients with epilepsy diagnosed during their first year of life who were submitted to a developmental check-up in the year 2007. The sample consisted of 60 patients (27 boys and 33 girls). Epidemiological and clinical data were collected, together with the findings from complementary examinations. The diagnostic criteria applied were those of the International League Against Epilepsy. RESULTS: The mean age at the time of diagnosis was 6.3 months. The mean follow-up time was 7.6 years. The aetiology was symptomatic in 40 cases (66.7%), cryptogenic in 16 (26.7%) and idiopathic in four cases (6.7%). Neuroimaging tests detected abnormalities in 34 patients (56.7%). West's syndrome (30%), symptomatic focal epilepsies (23.3%) and epilepsies linked to specific syndromes (16.7%) were the epileptic syndromes with the highest prevalence. Learning disabilities were observed in 82.5% of the children. CONCLUSIONS: Most epilepsies that present during the first year of life are symptomatic and/or cryptogenic, and are accompanied by psychoneurological impairment and/or resistance to therapy, which condition cognitive disorders that are eligible for specialised psycho-pedagogical intervention.
Subject(s)
Epilepsy/epidemiology , Child , Child, Preschool , Cognition Disorders/etiology , Epilepsy/classification , Epilepsy/complications , Epilepsy/diagnosis , Female , Humans , Infant , Infant, Newborn , Learning Disabilities/etiology , Male , Retrospective Studies , SyndromeABSTRACT
Objetivo. Analizar las características epidemiológicas y la distribución relativa de los distintos tipos de epilepsia y índromes epilépticos durante el primer año de vida. Pacientes y métodos. Se han revisado retrospectivamente las historias clínicas de todos los pacientes con epilepsia diagnosticada durante el primer año de vida, en quienes se realizó su control evolutivo en el año 2007. La muestra estaba compuesta por 60 pacientes (27 niños y 33 niñas). Se recogieron datos epidemiológicos y clínicos, así como exámenes complementarios. Los criterios diagnósticos aplicados fueron los de la Liga Internacional contra la Epilepsia. Resultados. La edad media en el momento del diagnóstico era de 6,3 meses. El tiempo medio de seguimiento era de 7,6 años. La etiología era sintomática en 40 casos (66,7%), criptogénica en 16 casos (26,7%) e idiopática en 4 (6,7%). En las pruebas de neuroimagen se detectaron anomalías en 34 pacientes (56,7%). El síndrome de West (30%), las epilepsias focales sintomáticas (23,3%) y las epilepsias ligadas con síndromes específicos (16,7%) eran los síndromes epilépticos de mayor prevalencia. El 82,5% de los niños tenían problemas de aprendizaje. Conclusiones. La mayoría de las epilepsias que se presentan durante el primer año de vida son sintomáticas y/o criptogénicas, y se acompañan de un deterioro psiconeurológico y/o de refractariedad terapéutica, que condicionan trastornos cognitivos susceptibles de intervención psicopedagógica especializada (AU)
Aim. To analyse the epidemiological characteristics and the relative distribution of the different types of epilepsy and epileptic syndromes during the first year of life. Patients and methods. An analysis was performed of the patient records of all patients with epilepsy diagnosed during their first year of life who were submitted to a developmental check-up in the year 2007. The sample consisted of 60 patients (27 boys and 33 girls). Epidemiological and clinical data were collected, together with the findings from complementary examinations. The diagnostic criteria applied were those of the International League Against Epilepsy. Results. The mean age at the time of diagnosis was 6.3 months. The mean follow-up time was 7.6 years. The aetiology was symptomatic in 40 cases (66.7%), cryptogenic in 16 (26.7%) and idiopathic in four cases (6.7%). Neuroimaging tests detected abnormalities in 34 patients (56.7%). West's syndrome (30%), symptomatic focal epilepsies (23.3%) and epilepsies linked to specific syndromes (16.7%) were the epileptic syndromes with the highest prevalence. Learning disabilities were observed in 82.5% of the children. Conclusions. Most epilepsies that present during the first year of life are symptomatic and/or cryptogenic, and are accompanied by psychoneurological impairment and/or resistance to therapy, which condition cognitive disorders that are eligible for specialised psycho-pedagogical intervention (AU)
Subject(s)
Humans , Male , Female , Infant , Epilepsy/epidemiology , Seizures/epidemiology , Brain Damage, Chronic/epidemiology , Risk Factors , Retrospective Studies , Disease Progression , Spasms, Infantile/epidemiology , ComorbidityABSTRACT
Reversible posterior leukoencephalopathy syndrome is a clinical-radiological phenomenon associated with headache, vomiting, lethargy, visual disturbances and seizures, concomitant with radiological abnormalities predominantly within posterior cerebral white matter due to cerebral edema. There are multiple triggers as acute hypertension, cancer, hematological disease, renal pathology, red cells transfusions and different drugs. We present two patients with reversible posterior leukoencephalopathy under treatment for acute lymphoblastic leukemia because of the probable association with vinca alkaloids.
Subject(s)
Antineoplastic Agents, Phytogenic/adverse effects , Posterior Leukoencephalopathy Syndrome/pathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Antineoplastic Agents, Phytogenic/therapeutic use , Child , Female , Humans , Posterior Leukoencephalopathy Syndrome/chemically inducedABSTRACT
La leucoencefalopatía posterior reversible (LEPR) es un síndrome clínico-radiológico caracterizado por cefalea, vómitos, alteración de conciencia, problemas visuales y convulsiones, que presenta de forma concomitante lesiones radiológicas, fundamentalmente en las regiones posteriores de la sustancia blanca debido al edema cerebral existente. Este cuadro se asocia a múltiples situaciones médicas, como hipertensión arterial aguda, cáncer, enfermedades hematológicas, enfermedad renal, transfusión de glóbulos rojos y múltiples fármacos, como inmunosupresores, y citostáticos, entre otras causas. Presentamos dos casos en niños con leucemia aguda linfoblástica (LLA), asociados probablemente a utilización de vincristina (AU)
Reversible posterior leukoencephalopathy syndrome is a clinical-radiological phenomenon associated with headache, vomiting, lethargy, visual disturbances and seizures, concomitant with radiological abnormalities predominantly within posterior cerebral white matter due to cerebral edema. There are multiple triggers as acute hypertension, cancer, hematological disease, renal pathology, red cells transfusions and different drugs. We present two patients with reversible posterior leukoencephalopathy under treatment for acute lymphoblastic leukemia because of the probable association with vinca alkaloids (AU)
