ABSTRACT
INTRODUCTION: prostate cancer is the most frequent solid malignant tumor in Western Countries. Positron emission tomography/x-ray computed tomography imaging with radiolabeled choline analogues is a useful tool for restaging prostate cancer in patients with rising prostate-specific antigen after radical treatment (in whom conventional imaging techniques have important limitations) as well as in the initial assessment of a selected group of prostate cancer patients. For this reason a literature review is necessary in order to evaluate the usefulness of this imaging test for the diagnosis and treatment of prostate cancer. EVIDENCE ACQUISITION: a MEDLINE (PubMed way) literature search was performed using the search parameters: «Prostate cancer¼ and «Choline-PET/CT¼. Other search terms were «Biochemical failure¼ and/or «Staging¼ and/or «PSA kinetics¼. English and Spanish papers were selected; original articles, reviews, systematic reviews and clinical guidelines were included. CONCLUSIONS: according to available data, radiolabeled choline analogues plays an important role in the management of prostate cancer, especially in biochemical relapse because technique accuracy is properly correlated with prostate-specific antigen values and kinetics. Although is an emerging diagnostic technique useful in treatment planning of prostate cancer, final recommendations have not been submitted.
Subject(s)
Prostatic Neoplasms/diagnostic imaging , Choline/analogs & derivatives , Humans , Male , Neoplasm Recurrence, Local/diagnostic imaging , Neoplasm Staging , Positron Emission Tomography Computed Tomography , Prostate-Specific Antigen , Prostatic Neoplasms/pathology , RadiopharmaceuticalsABSTRACT
Perivascular epithelioid tumors (PEComas) are a rare group of mesenchymal neoplasms with an unpredictable natural history and uncertain malignant potential. Uterine involvement and their association with tuberous sclerosis are typical for these tumors. We present a case of a 40-year old patient who was incidentally diagnosed of a uterine PEComa and serial studies of PET-CT with FDG were performed for staging and therapeutic response assessment. FDG PET-CT proved to be a valuable tool for detecting unsuspected pulmonary metastases and defining the reassessment of the patient after chemotherapy. The findings suggest that since this is a rare tumor, which does not always have benign behaviour, PET-CT may be a useful diagnostic imaging procedure for staging and clinical monitoring of patients who suffer this type of tumors.
Subject(s)
Endometrial Neoplasms/diagnostic imaging , Estrogens , Fluorine Radioisotopes , Fluorodeoxyglucose F18 , Lung Neoplasms/secondary , Neoplasms, Hormone-Dependent/diagnostic imaging , Perivascular Epithelioid Cell Neoplasms/diagnostic imaging , Positron-Emission Tomography , Radiopharmaceuticals , Tomography, X-Ray Computed , Adult , Angiofibroma/diagnostic imaging , Angiofibroma/genetics , Chemotherapy, Adjuvant , Combined Modality Therapy , Endometrial Neoplasms/pathology , Endometrial Neoplasms/surgery , Facial Neoplasms/genetics , Female , Humans , Hysterectomy , Incidental Findings , Kidney Neoplasms/diagnostic imaging , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/drug therapy , Neoplasms, Hormone-Dependent/drug therapy , Neoplasms, Hormone-Dependent/secondary , Neoplasms, Hormone-Dependent/surgery , Neoplasms, Multiple Primary/diagnostic imaging , Perivascular Epithelioid Cell Neoplasms/drug therapy , Perivascular Epithelioid Cell Neoplasms/secondary , Perivascular Epithelioid Cell Neoplasms/surgery , Tuberous Sclerosis/diagnostic imaging , Tuberous Sclerosis/geneticsABSTRACT
El trastorno de hiperactividad y déficit de atención es el trastorno más frecuente en la neurología del desarrollo.Las características clínicas son evolutivamente diferentes, llegando a manifestarse incluso en la edad adulta.Como su propio nombre indica, se caracteriza por la presencia de inquietud motriz, impulsividad y dispersión atencional. El diagnóstico es exclusivamente clínico; la detección precoz de este trastorno, así como los abordajes farmacológico y psicológico adecuados son necesarios para el buen rendimiento escolar y la adecuada adaptación social y laboral de estos pacientes (AU)
Subject(s)
Female , Child, Preschool , Male , Child , Humans , Attention Deficit Disorder with Hyperactivity/diagnosis , Attention Deficit Disorder with Hyperactivity/physiopathology , Attention Deficit Disorder with Hyperactivity/therapyABSTRACT
OBJECTIVE: To discover the sort of adverse reactions to medication (ARM) notified by Primary Care doctors and identify the under-notification of those cases having special clinical-epidemiological interest. DESIGN: Retrospective study in which 2,597 ARM corresponding to 1,467 Yellow Cards (YC) were analysed. These were notified by Primary Care doctors to the Centro Andaluz de Farmacovigilancia (Andalusian Drug-watch centre) during the period from 1/6/90 to 31/12/92. To assess the seriousness of the ARM, their terminological classification and imputability, the criteria used in the WHO's international "Yellow Card" programme of spontaneous notification were followed. MEASUREMENTS AND MAIN RESULTS: 77.2% of all notifications were from Primary Care, of which 7.4% were of special interest due to their serious or novel character. However an undernotification of serious and well-known ARM was detected, such as digestive haemorrhages (1.07/10(6) inhibitants per year), anaphylactic shock (0.34/10(6) inhab/year), agranulocytosis (0.23/10(6) inhab/year) and aplastic anaemia (0.05/10(6) inhab/year), among others. CONCLUSIONS: Most of the main under-notified ARM are generated in the community but treated in hospital Casualty departments. Therefore it would be useful to develop specific Drug-watch programmes in the hospitals themselves.
