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1.
Eur J Prev Cardiol ; 19(6): 1290-5, 2012 Dec.
Article in English | MEDLINE | ID: mdl-21914687

ABSTRACT

BACKGROUND: High levels of lipoprotein(a) [Lp(a)] have been linked to an increased risk of ischaemic cardiovascular events. We examined whether Lp(a) plasma levels are associated with early arteriosclerosis by measuring intima media thickness in an asymptomatic population of Burgos, Spain. METHODS: We determined lipids, lipoprotein(a) by a nephelometry method and the intima-media thickness (IMT) in the far wall of both common carotid arteries by B-mode ultrasound in a group of 172 asymptomatic subjects. RESULTS: No association was found in the population group between Lp(a) concentrations and left, right, or overall mean IMT by univariate or multivariate regression analysis. The median IMT was not significantly different in individuals with Lp(a) levels >300 mg/l and in individuals with Lp(a) levels <300 mg/l. CONCLUSIONS: These results suggest that increased Lp(a) levels do not confer cardiovascular risk by promoting early atherogenesis, but rather increasing the susceptibility to thrombosis.


Subject(s)
Carotid Artery Diseases/blood , Carotid Artery Diseases/diagnostic imaging , Carotid Artery, Common/diagnostic imaging , Carotid Intima-Media Thickness , Lipoprotein(a)/blood , Aged , Asymptomatic Diseases , Biomarkers/blood , Early Diagnosis , Female , Humans , Linear Models , Male , Middle Aged , Multivariate Analysis , Nephelometry and Turbidimetry , Predictive Value of Tests , Risk Factors , Spain , Up-Regulation
2.
Article in Spanish | IBECS | ID: ibc-96856

ABSTRACT

Objetivo El propósito de este estudio es evaluar el tipo de parto y la morbilidad materna asociados a las gestaciones que finalizan en la semana 41. Material y métodos Se ha diseñado un estudio de cohortes históricas. El tipo de parto y las complicaciones maternas de 230 gestaciones de 41 semanas se compararon con 234 gestaciones que finalizaron entre las 37 y las 40 semanas de gestación en el Hospital Universitario Miguel Servet en 2005. Resultados Se evidencia que las mujeres que finalizan la gestación en la semana 41 tienen un mayor riesgo de despegamiento de membranas, Bishop desfavorable al ingreso, inducción y mayor duración del parto. También se pone de manifiesto un incremento de las tasas de parto instrumentado (25,6 vs 17,6%, p<0,001) y de cesárea (21,70 vs 8,50%, p<0,001). Conclusiones La tasa de complicaciones maternas periparto se incrementa cuando se alcanza la semana 41 de gestación. La apropiada investigación de este hecho es importante en la determinación de la edad gestacional a la cual el riesgo de continuar el embarazo supera el riesgo de una inducción de parto (AU)


Objective To evaluate the mode of delivery and maternal morbidity associated with pregnancies ending at 41 weeks. Material and methods We designed a retrospective cohort study. The mode of delivery and maternal complications of 230 pregnancies ending at 41 weeks were compared with those in 234 pregnancies ending between 37 and 40 weeks at the Miguel Servet University Hospital in 2005. Results Women delivering at 41 weeks had an increased risk of membrane sweep, un favorable Bishop score at admission, induction and longer duration of labor. These increases were also seen in the rates of operative vaginal delivery (25.6 vs 17.6%, p<0.001) and cesarean section (21.7 vs 8.5%, p<0.001). Conclusions The rates of maternal peripartum complications increase as pregnancy reaches 41 weeks. Accurate investigation of these rates is important to determine the gestational age at which the risk of continuing the pregnancy outweighs the risk of labor induction (AU)


Subject(s)
Humans , Female , Pregnancy , Pregnancy, Prolonged/epidemiology , Obstetric Labor Complications/epidemiology , Pregnancy Complications/epidemiology , Gestational Age , Risk Factors , Cohort Studies
3.
Rehabilitación (Madr., Ed. impr.) ; 42(5): 224-230, sept. 2008. tab
Article in Es | IBECS | ID: ibc-68982

ABSTRACT

Introducción. El infarto agudo de miocardio (IAM) es la entidad que produce mayor morbimortalidad en los países desarrollados. Afecta la calidad de vida del paciente y su situación laboral, generando un importante gasto económico. La rehabilitación cardiaca tiene entre sus metas prolongar la vida, reducir los síntomas, mejorar la función física, promover el buen estado general y facilitar la reanudación de la actividad diaria. El objetivo de este estudio es valorar la eficacia de la rehabilitación en pacientes que han sufrido un IAM en relación con la calidad de vida, la reincorporación laboral y el tiempo de baja tras el episodio coronario agudo. Material y métodos. Se seleccionaron 26 pacientes que habían sufrido un IAM. Todos siguieron el mismo tratamiento convencional. A 12 de estos pacientes se les añadió un programa de rehabilitación cardiaca. Entre 1-1,5 años después se evaluó la salud relacionada con la calidad de vida (cuestionario SF-36) y se obtuvieron parámetros relacionados con su actividad laboral. Resultados. La reinserción laboral tras 1-1,5 años del IAM mostró diferencias estadísticamente significativas a favor de los pacientes que realizaron rehabilitación. Aquellos que no han seguido el programa de rehabilitación han estado más tiempo en situación de incapacidad laboral temporal tras IAM (no estadísticamente significativa). Con excepción de la escala de dolor corporal, los pacientes que han seguido tratamiento rehabilitador tienen puntuaciones mayores en todas las demás del cuestionario SF-36; son estadísticamente significativas en 4 subescalas. Discusión. Un programa de rehabilitación tras un IAM mejora la percepción del control emocional, de la capacidad física y de la capacidad para volver al trabajo


Introduction. Acute myocardial infarction (AMI) produces more morbidity-mortality than any other disease in developed countries. It affects the patient¿s quality of life and work situation, generating significant economic cost. Among the goals of cardiac rehabilitation are: to prolong the patient¿s life, reduce symptoms, improve physical function, promote good general state and facilitate the resumption of daily activity. The aim of this study is to assess the effectiveness of rehabilitation in patients who have suffered AMI in relationship with quality of life, return to work and time of sick leave after an acute coronary episode. Material and methods. Twenty-six patients with AMI were selected. All of them received the same conventional treatment. Twelve of them were included in a cardiac rehabilitation program. Health-related quality of life (SF-36 questionnaire) was evaluated between 1-1.5 years later and the parameters related with their work activity were obtained. Results. There were statistically significant differences regarding return to work after 1-1.5 years of the AMI in favor of patients with rehabilitation (p < 0.05). Those who did not follow the rehabilitation program spent more time on sick leave for incapacity after the AMI (p > 0.05). Except for the body pain scale, those patients who had followed rehabilitation treatment had higher scores on all the other items of the SF-36 questionnaire. These were statistically significant in 4 subscales. Discussion. Rehabilitation programs after an AMI improves the patient¿s perception of his or her emotional control, physical capacity and return to work


Subject(s)
Humans , Rehabilitation, Vocational/trends , Myocardial Infarction/rehabilitation , Statistics on Sequelae and Disability , Work Capacity Evaluation
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