ABSTRACT
OBJECTIVES: To report a case of synchronic neoplasia--chromophobe renal cell carcinoma and low grade non Hodgkin lymphoma--in a 38-year-old male patient, because, although association of these two neoplasias is known, the fact of renal neoplasia being a chromophobe carcinoma is rarely referred to in medical bibliography (3 cases described after Med-Line search). METHODS/RESULTS: The diagnostic study included ultrasound and CT scan in a patient presenting with in non specific abdominal symptoms and neck adenopathy; patient underwent left radical nephrectomy and excision of neck adenopathy. Histologic and immuno-histochemical studies revealed the coexistence of chromophobe type renal cell carcinoma and diffuse centrocytic lymphoma. CONCLUSIONS: Column in the association between chromophobe histological type renal cell carcinoma and non Hodgkin lymphoma is very rare. Presence of these two tumors in the same patient may pose problems for clinical staging, prognostic predictions, and treatment. Then, due to the fact that it is not usual and that a local stage renal carcinoma presents with neck adenopathies, when they appear possible coexistence of these tumors should be suspected.
Subject(s)
Carcinoma, Renal Cell/pathology , Kidney Neoplasms/pathology , Lymphoma, Mantle-Cell/pathology , Lymphoma, Non-Hodgkin/pathology , Neoplasms, Multiple Primary/pathology , Adult , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Renal Cell/diagnosis , Carcinoma, Renal Cell/drug therapy , Carcinoma, Renal Cell/surgery , Combined Modality Therapy , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Humans , Kidney Neoplasms/diagnosis , Kidney Neoplasms/drug therapy , Kidney Neoplasms/surgery , Lymphoma, Mantle-Cell/diagnosis , Lymphoma, Mantle-Cell/drug therapy , Lymphoma, Mantle-Cell/surgery , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/surgery , Male , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Multiple Primary/drug therapy , Neoplasms, Multiple Primary/surgery , Nephrectomy , Prednisone/administration & dosage , Tomography, X-Ray Computed , Vincristine/administration & dosageABSTRACT
OBJETIVO: Comunicar un caso de diagnóstico neoplásico sincrónico: carcinoma renal de tipo cromófobo y linfoma no Hodgkin de bajo grado, en un paciente varón de 38 años de edad, ya que, aunque la asociación de estas dos neoplasias es conocida, el que la neoplasia renal corresponda a un carcinoma de tipo cromófobo es un hecho escasamente referido en la literatura (3 casos descritos, según búsqueda bibliográfica Med-Line). MÉTODOS/RESULTADOS: El estudio diagnóstico se realizó mediante ecografía y tomografía, en un paciente con clínica abdominal inespecífica y adenopatías cervicales, practicándose posteriormente una nefrectomía radical izquierda y la resección de una adenopatía cervical. El estudio histológico e inmunohistoquímico correspondiente puso de manifiesto la coexistencia de un carcinoma renal de tipo "cromófobo" y un linfoma centrocítico difuso. CONCLUSIONES: La asociación entre el carcinoma renal subtipo histológico cromófobo y el linfoma no Hodgkin es muy infrecuente. La presencia de estos dos tumores en un mismo paciente puede plantear problemas de estadiaje, predicción pronóstica y tratamiento. Por tanto, dado que no es habitual que un carcinoma renal en estadio local presente adenopatías cervicales, en estos casos debería sospecharse esta posible coexistencia (AU)
