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1.
Braz J Microbiol ; 51(4): 1601-1605, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32749573

ABSTRACT

Phylogenetic studies with Zika virus (ZIKV) have been conducted in Brazil. In this study, we sequenced 8 new sequences of the ZIKV envelope (E) gene from strains of cases from the Paraná and Mato Grosso do Sul states in 2016. A low phylogenetic signal was observed, with more than 40% of unresolved quartets, and the Maximum Likelihood Tree grouped all sequences in the Brazilian branches within the Asian genotype. In addition, a Shannon entropy analysis was conducted, showing a high stability in the E protein through the ZIKV polyprotein. Taken together, these results suggest a high degree of conservation in the ZIKV E gene from the recent American outbreaks.


Subject(s)
Disease Outbreaks , Viral Envelope Proteins/genetics , Zika Virus Infection/virology , Zika Virus/genetics , Brazil/epidemiology , Genes, Viral , Genome, Viral , Genotype , Humans , Viral Envelope/metabolism
2.
Int J Mol Sci ; 16(11): 27912-20, 2015 Nov 24.
Article in English | MEDLINE | ID: mdl-26610484

ABSTRACT

kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair. kin17 has been studied as a potential molecular marker of breast cancer. This work reports the detection and localization of this protein in the murine melanoma cell line B16F10-Nex2 and in two derived subclones with different metastatic potential, B16-8HR and B16-10CR. Nuclear and chromatin-associated protein fractions were analyzed, and kin17 was detected in all fractions, with an elevated concentration observed in the chromatin-associated fraction of the clone with low metastatic potential, suggesting that the kin17 expression level could be a marker of melanoma.


Subject(s)
DNA-Binding Proteins/metabolism , Melanoma/metabolism , Nuclear Proteins/metabolism , Animals , Cell Movement , Chromatin/metabolism , DNA Repair , DNA Replication , Isografts , Melanoma/genetics , Melanoma/pathology , Melanoma, Experimental , Mice , Neoplasm Metastasis
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