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Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.
Pascu, Sofia I; Waghorn, Philip A; Conry, Timothy D; Lin, Bonita; Betts, Helen M; Dilworth, Jonathan R; Sim, Robert B; Churchill, Grant C; Aigbirhio, Franklin I; Warren, John E.
Dalton Trans ; (16): 2107-10, 2008 Apr 28.
Article in English | MEDLINE | ID: mdl-18398535

ABSTRACT

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.


Subject(s)
Carcinoma/drug therapy , Organometallic Compounds/chemistry , Organometallic Compounds/pharmacology , Thiosemicarbazones/chemistry , Zinc/chemistry , Apoptosis/drug effects , Carcinoma/pathology , Cell Line, Tumor , Crystallography, X-Ray , Drug Screening Assays, Antitumor , Humans , Lethal Dose 50 , Microscopy, Confocal , Mitochondria/drug effects , Models, Molecular , Molecular Structure , Organometallic Compounds/chemical synthesis , Spectrometry, Fluorescence , Toxicity Tests
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