ABSTRACT
and mobile phone use, prefrontal symptomology and dispositional mindfulness in university students. This study analyzes the relationship between the type of alcohol use and parameters associated with addictive behaviors, such as abnormal use of the Internet and mobile devices, prefrontal symptoms and dispositional mindfulness in 509 university students from Madrid (Spain). The present study was multivariate, inferential, descriptive and nonexperimental, using discriminant analysis to study the predictive nature of the variables considered in weekend alcohol use, with participants classified into three groups (low, medium and high use). The results indicate that high alcohol use was related to greater Internet and mobile phone use, greater irritability and under executive control, as well as a lower mindfulness level. Longitudinal studies are needed to analyze, among other aspects, the mediating role of dispositional mindfulness in alcohol use, use of technologies and executive functioning (AU)
Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Alcohol Drinking , Internet Access , Cell Phone , Students/psychology , Prefrontal Cortex , Mindfulness , Cross-Sectional Studies , UniversitiesABSTRACT
La enfermedad de Chagas es todavía un importante problema de salud pública en América Latina, donde afecta especialmente a las personas con menos recursos económicos de las áreas rurales. Fue descubierta en 1909 por el médico brasileño Carlos Chagas y, aunque durante muchos años los resultados obtenidos en la lucha contra la enfermedad fueron limitados, a partir de 1991, gracias a las iniciativas llevadas a cabo por los países del Cono Sur, se logra-ron avances importantes. La prevención de la enfermedad se basa en tres pila-res fundamentales, la lucha contra el vector, la prevención centrada en los mecanismos de transmisión y la mejora de las viviendas de las áreas rurales y la realización precoz del diagnóstico y el tratamiento. En cuanto al tratamiento, se siguen utilizando toda-vía dos preparados, comercializados en los años 60-70 del siglo pasado, Nifurtimox y Benznidazol, que presentan con frecuencia reacciones adversas. Sería fundamental, disponer de preparados con mayor eficacia, menor coste y con menos efectos adversos
Chagas disease still is an important problem of public health in Latin America. It especially affects people in the rural areas and with restricted economic resources.Chagas disease was first discovered by a Brazilian medical doctor named Carlos Chagas in 1909. In spite of limited results for years, from 1991 on, and thanks to initiatives taken by the Southern Cone countries, some important advantages were obtained. Prevention of this disease is based on three fundamental pillars: fight against the vector; education of population regarding the different mechanisms of transmission and the symptoms presented by the disease.These educational measures should be complement-ed by the improvement of the housing in the rural areas and the early diagnosis and treatment.Regarding treatment, two preparations are still in use since the ́60 and ́70 decades of the last century: Nifurtinox and Benznidazul. Both present frequent adverse reactions. It would be of fundamental impor-tance to count on medications that would be more efficient, less expensive and with less adverse effects
Subject(s)
Humans , Animals , History, 20th Century , History, 21st Century , Chagas Disease , Trypanosoma cruzi , Insect Vectors/classification , Triatominae , Bedbugs , Chagas Disease/epidemiology , Chagas Disease/history , Chagas Disease/prevention & control , Chagas Disease/therapyABSTRACT
El tifus epidémico, está causado por Rickettsia Prowazekii, y es transmitido por el piojo del cuerpo. Durante siglos, ha producido epidemias devastadoras, considerándose que esta infección ha causado más muertes que todas las guerras juntas. La primera epidemia de la que existe constancia tuvo lugar durante el cerco de Granada por los Reyes Católicos, en 1489. Desde entonces hasta el siglo XX, ha acompañado en numerosas ocasiones a los ejércitos, habiendo sido la enfermedad decisiva en algunos casos, para el resultado de los conflictos, debido al número de fallecidos que ocasionó. Algunas situaciones concretas, como guerras, campamentos de refugiados, hacinamiento e inadecuadas condiciones higiénicas, favorecen el desarrollo de la enfermedad. El descubrimiento por Charles Nicolle (1856-1936) del vector de transmisión, el piojo del cuerpo, supuso un avance sustancial en el control de la misma y la llegada de los antibióticos hizo posible su curación
Epidemic typhus is caused by Rickettsia prowazekii and it is transmitted through body lice. For centuries, due to devastating epidemics it has caused more casualties than all wars known in humanity. The first epidemic of which we have record, took place during the siege of Granada by the Spanish Catholic King and Queen in 1489. Since then, and up to the 20th. century, typhus has been linked to armies in combat. Given the large number of deaths caused by this disease, its presence has been crucial in the results of certain conflicts. Certain situations favor the development of typhus epidemics such as wars, overcrowding, refugee camps and inadecuate hygienic conditions. The discovery by Charles Nicolle (1856-1936) of the transmission mechanism by body lice, was a substantial step towards controlling the disease. The appearance of antibiotics determined its definite healing
Subject(s)
Humans , Typhus, Epidemic Louse-Borne/epidemiology , Rickettsia prowazekii/pathogenicity , Typhus, Epidemic Louse-Borne/prevention & control , Epidemics/historyABSTRACT
La brucelosis es una zoonosis distribuida por la mayor parte del mundo. En España tuvo una incidencia importante, estimándose en 5.000 los casos anuales al final de la primera mitad del s.XX, llegando a 8.692 casos en 1984, lo que hizo que se pusieran en marcha programas de control, que contribuyeron a reducir el número de casos, hasta los 103 declarados en 2013. La enfermedad, ha tenido una importante repercusión sanitaria y socioeconómica por la afectación del hombre y de los animales. Su pronóstico en general, ha sido bueno, salvo complicaciones. El tratamiento en las primeras décadas del s. XX, era básicamente sintomático, al no disponerse de ningún remedio efectivo. Posteriormente, los arsenicales, las sales de oro y la vacuna intravenosa, entre otros, tuvieron una aportación destacable, hasta la llegada de los antibióticos, que supuso un cambio radical en la evolución de la enfermedad (AU)
Brucellosis is a zoonosis spread throughout the world. It had a rather important incidence in Spain. An estímate of of 5000 cases per year took place in Spain during the first half of the 20th. century, reaching a peak of 8,692 in 1984. This fact promoted the establishment of control mechanisms that contributed to gradually diminish the number of cases to 103 in 2013. Brucellosis has had a considerable importance both in the health and socioeconomic fields due to vulnerability in humans and animals. The disease had a good prognosis, putting aside possible complications. Treatment, in the first decades of the 20th. Century was basically symptomatic, given the lack of effective remedies. Later, arsenic components, gold salts and the intravenous vaccine, among others, had a relevant importance in treatment until the appearance of antibiotics. These had a radical influence in the natural evolution of the disease (AU)
Subject(s)
Humans , Male , Female , Brucellosis/epidemiology , Brucellosis/prevention & control , Preventive Medicine/history , Preventive Medicine/methods , Brucellosis/history , Prognosis , Brucellosis/etiology , Brucella melitensis/isolation & purification , Brucella melitensis/pathogenicity , Pre-Exposure Prophylaxis/organization & administration , Pre-Exposure Prophylaxis/standardsABSTRACT
α-synuclein is a key protein in Lewy body diseases (LBDs) and a major component of Lewy bodies and related aberrant cytoplasmic and neuritic inclusions. Regional differences in α-synuclein have been associated with selective neuronal vulnerability to Lewy pathology. Furthermore, phosphorylation at serine 129 (Ser129) and α-synuclein truncation have been considered crucial in the pathogenesis of Lewy inclusions. The present study shows consistent reduction in α-synuclein protein expression levels in the human substantia nigra and nucleus basalis of Meynert compared with other brain regions independently of age and pathology. Phosphorylated α-synuclein at Ser129 is naturally increased in these same regions, thus inversely related with the total amount of α-synuclein. In contrast, truncated α-synuclein is naturally observed in control and diseased brains and correlating with the total amount of α-synuclein. Several truncated variants have been identified where some of these variants are truncated at the C-terminal domain, whereas others are truncated at the N-terminal domain, and all are present in cases with and without Lewy pathology. Although accumulation of truncated α-synuclein variants and phosphorylated α-synuclein occurs in Lewy bodies, α-synuclein phosphorylation and truncation can be considered constitutive in control and diseased brains.
Subject(s)
Brain/metabolism , Serine/metabolism , alpha-Synuclein/metabolism , Adult , Aged , Aged, 80 and over , Animals , Brain/cytology , Cell Line, Tumor , Female , Humans , Lewy Bodies/metabolism , Lewy Body Disease/metabolism , Lewy Body Disease/pathology , Male , Mass Spectrometry , Mice , Mice, Transgenic , Microscopy, Confocal , Middle Aged , Mutation/genetics , Nerve Tissue Proteins/metabolism , Neuroblastoma/pathology , Neurons/ultrastructure , Phosphorylation/physiology , Postmortem Changes , Protein Structure, Tertiary/genetics , Subcellular Fractions/metabolism , Time Factors , Transfection/methods , alpha-Synuclein/geneticsABSTRACT
The evolutionarily conserved 50K protein of Escherichia coli, encoded by o454, contains a consensus GTP-binding motif. Here we show that 50K is a GTPase that differs extensively from regulatory GTPases such as p21. Thus, 50K exhibits a very high intrinsic GTPase hydrolysis rate, rather low affinity for GTP, and extremely low affinity for GDP. Moreover, it can form self-assemblies. Strikingly, the 17 kDa GTPase domain of 50K conserves the guanine nucleotide-binding and GTPase activities of the intact 50K molecule. Therefore, the structural requirements for GTP binding and GTP hydrolysis by 50K are without precedent and justify a separate classification in the GTPase superfamily. Immunoelectron microscopy reveals that 50K is a cytoplasmic protein partially associated with the inner membrane. We prove that o454 is allelic with trmE, a gene involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs. Our results demonstrate that 50K is essential for viability depending on the genetic background. We propose that combination of mutations affecting the decoding process, which separately do not reveal an obvious defect in growth, can give rise to lethal phenotypes, most likely due to synergism.
