Dietary restriction improves systemic and muscular oxidative stress in type 2 diabetic Goto-Kakizaki rats

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Type 2 diabetes is a heterogeneous metabolic disease characterized by insulin resistance and Beta-cell dysfunction leading to hyperglycaemia and dyslipidaemia. Dietary intervention seems to improve some of these cellular complications, namely insulin resistance. Our aim was to evaluate the effects of dietary restriction on systemic and skeletal muscle oxidative stress and insulin resistance in normal Wistar rats and (..) (AU)