ABSTRACT
A amiloidose AL é uma doença que resulta da deposição tecidual de cadeias leves de imunoglobulinas, ocorrendo em 15% dos doentes com mielomamúltiplo. As manifestações mucocutâneas frequentemente antecedem o aparecimento de outros sintomas de gamapatia monoclonal, possibilitando um diagnóstico mais precoce. Descrevemos o caso de um doente de 71 anos que recorreu à consulta por lesões cutâneas nas pálpebras, sulcos retroauriculares e dorso, cuja biópsiarevelou depósitos amilóides. A investigação subsequente identificou a existência de mieloma múltiplo (AU)
AL amyloidosis results from tissue deposition of immunoglobulin light chains, occurring in 15% of patients with multiple myeloma. Mucocutaneouslesions are often the first manifestations, helping in earlier recognition of monoclonal gamapathy.We present the case of a 71-year-old man who presented with cutaneous lesions on the eyelids, retroauricular folds and upper back, which proved to be due to amyloid deposition. Further investigation revealed multiple myeloma (AU)
Subject(s)
Humans , Male , Aged , Amyloidosis/complications , Multiple Myeloma/complications , Diagnosis, Differential , MyelographyABSTRACT
A amiloidose AL é uma doença que resulta da deposição tecidual de cadeias leves de imunoglobulinas, ocorrendo em 15% dos doentes com mielomamúltiplo. As manifestações mucocutâneas frequentemente antecedem o aparecimento de outros sintomas de gamapatia monoclonal, possibilitandoum diagnóstico mais precoce.Descrevemos o caso de um doente de 71 anos que recorreu à consulta por lesões cutâneas nas pálpebras, sulcos retroauriculares e dorso, cuja biópsiarevelou depósitos amilóides. A investigação subsequente identificou a existência de mieloma múltiplo (AU)
AL amyloidosis results from tissue deposition of immunoglobulin light chains, occurring in 15% of patients with multiple myeloma. Mucocutaneouslesions are often the first manifestations, helping in earlier recognition of monoclonal gamapathy.A 71-year-old man who with cutaneous lesions on the eyelids, retroauricular folds and upper back, which proved to be due to amyloid deposition isreported. Further investigation revealed multiple myeloma (AU)
Subject(s)
Humans , Male , Aged , Amyloidosis/diagnosis , Amyloidosis , Multiple Myeloma/complications , Multiple Myeloma/diagnosis , Multiple Myeloma/drug therapy , Multiple Myeloma/pathologyABSTRACT
Oil of turpentine is still a common allergen in Portugal although it does not contain delta 3-carene, as ascertained by gas chromatography. Patch tests with 6 terpenes on 22 patients revealed that 17 were allergic to alpha-pinene and 15 to dipentene; 12 were allergic to both. 4 patients were sensitive to delta 3-carene, 3 to alpha-terpineol and 2 to beta-pinene. These results explain the incidence of allergy to oil of turpentine in Portugal.
Subject(s)
Dermatitis, Contact/etiology , Oils/adverse effects , Turpentine/adverse effects , Female , Humans , Male , Patch Tests , Portugal , Terpenes/adverse effectsABSTRACT
9 patients with typical textile dermatitis were found to be allergic to dark polyester blouses. Thin-layer chromatography of the dyes extracted from the fabrics identified the presence of several dyes, from which Disperse Blue 106 was positive in all patients.
Subject(s)
Azo Compounds/adverse effects , Coloring Agents/adverse effects , Dermatitis, Contact/etiology , Adult , Azo Compounds/isolation & purification , Coloring Agents/isolation & purification , Dermatitis, Contact/diagnosis , Female , Humans , Middle Aged , Patch Tests , TextilesSubject(s)
Dermatitis, Occupational/etiology , Photography , Toluene/analogs & derivatives , Adult , Female , Humans , Skin Tests , Toluene/adverse effectsABSTRACT
Thin-layer (uni-dimensional and bi-dimensional) chromatography studies were performed on 52 beige stockings and pantyhose from different countries. They demonstrated the presence of Disperse Yellow 3 in 51 and Disperse Orange 3 in 15 stockings. In the absence of isolation and spectroscopic identification of the dyes, these results are strong clues to their presence.
Subject(s)
Azo Compounds/analysis , Chromatography, Thin Layer , Clothing/adverse effects , Coloring Agents/analysis , Dermatitis, Contact/etiology , HumansSubject(s)
Dermatitis, Contact/etiology , Thiazoles/adverse effects , Benzothiazoles , Chemical Phenomena , Chemistry , Humans , RubberABSTRACT
Garlic (Allium sativum L.) water- and ethanol-soluble extracts were prepared and purified by column chromatography. They were tested on garlic-sensitive patients and showed that the allergenic fraction was well located in a few column chromatography fractions. Guinea-pigs were sensitized with garlic water-soluble extracts and tested (open epicutaneous tests) with several fractions. The presence of diallyldisulfide was detected in the sensitizing chromatographic fractions. Guinea-pigs were successfully sensitized to this product and cross-reacted to garlic; animals sensitized to garlic extracts cross-reacted to diallyldisulfide. Both groups reacted to allicin, an oxidized derivative of diallyldisulfide present in garlic. Garlic-sensitive patients showed positive tests to diallyldisulfide, allylpropyldisulfide, allylmercaptan and allicin.
