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1.
Rev Chilena Infectol ; 23(2): 140-9, 2006 Jun.
Article in Spanish | MEDLINE | ID: mdl-16721448

ABSTRACT

A retrospective study was designed to ascertain the main clinical features of 30 patients admitted for brain abscess between 1989 and 2005. A contiguous source of infection was identified in 40% of cases, direct inoculation secondary to trauma or neurosurgery in 23,3%, and a distant source in 23,3%. Fever, headache and sensorial involvement were the main clinical manifestations. Temporal and frontal lesions were predominant. Microbiological information was available in only half of cases, prevailing polymicrobial and gram-positive bacterial infections. Most patients underwent surgical procedures (66.7%) and the rest received only medical therapy. During antimicrobial treatment, 6 patients (20%) suffered a serious adverse event that prompted discontinuation or change of therapy. Failure of treatment was observed in 40%, including 3 deaths (10%), non-programmed surgical drainage or reintervention (16.7%) and changes of the antimicrobial regimen (13.3%). Eight patients were discharged with sequels (26.7%), and during follow-up, 21% presented major events (death or brain abscess-related readmission).


Subject(s)
Brain Abscess , Adolescent , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Brain Abscess/complications , Brain Abscess/microbiology , Brain Abscess/therapy , Combined Modality Therapy , Drainage , Female , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors
2.
Rev. chil. infectol ; 23(2): 140-149, jun. 2006. tab, graf
Article in Spanish | LILACS | ID: lil-427833

ABSTRACT

Se diseñó un estudio para conocer las principales características clínicas en 30 pacientes atendidos por absceso cerebral entre 1989 y 2005. La puerta de entrada predominante fue por contigüidad (40 por ciento) y luego inoculación directa por neurocirugía-trauma o diseminación hematógena (23,3 por ciento). La fiebre, cefalea y el compromiso de conciencia fueron las manifestaciones cardinales y la localización predominante fue temporal o frontal. Se observó un predominio de infecciones polimicrobianas y por cocáceas gram positivas. La mayor parte fue sometida a tratamiento quirúrgico (66,7 por ciento) y el resto a tratamiento médico solamente. Durante el tratamiento antimicrobiano, 6 pacientes (20 por ciento) presentaron una reacción adversa que obligó a su suspensión o a cambio. Se observó fracaso del tratamiento médico-quirúrgico en 40 por ciento de los casos, incluyendo 3 decesos (10 por ciento letalidad), drenaje quirúrgico no programado o reintervenciones (16,7 por ciento) o ajustes de esquema (13,3 por ciento). Ocho pacientes presentaron secuelas al alta (26,7 por ciento) y durante el seguimiento, 21 por ciento presentó rehospitalizaciones relacionadas o falleció.


Subject(s)
Brain Abscess/diagnosis , Brain Abscess/etiology , Brain Abscess/therapy , Brain Abscess/complications , Chile , Disease-Free Survival , Follow-Up Studies , Prognosis , Risk Factors , Sex Distribution , Signs and Symptoms
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