ABSTRACT
OBJECTIVES: To evaluate the relationship of the immune-checkpoint PD-1/PD-L1 with the clinical evolution of OSCC; to assess survival in OSCC based on the characteristics of TME and histologic risk score; to evaluate the clinical and histopathological relationship of OSCC with immunological TME. MATERIAL AND METHODS: A retrospective study was carried out on 65 samples from patients with OSCC on the floor of the mouth or tongue. Clinicopathological variables and the expression of the biomarkers PD-1, PD-L1, FoxP3, CD4, CD8, CSF1R, and p16 were recorded. The relationship of the clinical and histological variables with the expression of the biomarkers and survival was studied. RESULTS: The univariate and multivariate analysis indicated that positive PD-1 expression was an independent protective factor for survival (overall, disease-free, disease-specific survival) and that high PD-L1 also improved survival. Poorly differentiated histological grades and metastasis were associated with a worse prognosis. CONCLUSIONS: PD-1 is a protective survival factor that is maintained independently of PD-L1 expression. High values of PD-L1 expression also improve survival. Higher expression of PD-1 is observed in smaller tumors, and higher expression of PD-L1 is more likely in women. No relationship between the tumor microenvironment and histologic risk score was found to influence the survival patterns studied in the OSCC. There is no evidence of a relationship between the histopathological features and the studied markers, although the positive PD-1 and PD-L1 cases have a lower risk of a high WPOI score, and positive PD-1 expression was associated with a lower DOI.
ABSTRACT
Background: Oral mucositis (OM) is a painful lesion that takes place in the mucosa of the oral cavity, usually itsetiology is associated with drug therapies in cancer patients. It is presented as well-defined ulcers whose painfulsymptomatology sometimes implies the suspension of oncological treatment or parenteral feeding, being there-fore an important adverse effect, marking the evolution of these types of therapies against cancer. The presentwork aim is to know the prevalence of oral mucositis in oral cancer immunotherapy compared to its prevalencein standard therapy.Material and Methods: A protocol was developed for a systematic review following PRISMA® guidelines and afocused question (PICO) was constructed. A comprehensive literature search was conducted on electronic data-bases including PubMed, the SCOPUS database, the Cochrane library and the Web of Science (WOS).Results: Six clinical trials were included that met the different inclusion criteria. In these articles, a discrepancybetween the prevalence of OM in patients treated with chemotherapy and patients treated with immunotherapyrelated to the immune checkpoint PD-1/PD-L1 (Nivolumab and Pembrolizumab) was observed. Conclusions: The prevalence of oral mucositis is lower in new immunotherapy with monoclonal antibodies againstoral cancer than drugs used so far (chemotherapy drugs [methotrexate, cisplatin] as well as cetuximab). However,more studies should be carried out to confirm these data.(AU)
Subject(s)
Humans , Male , Female , Mouth/injuries , Stomatitis , Immunotherapy , Mouth Neoplasms/drug therapy , Stomatitis/chemically induced , Oral Health , Pathology, Oral , Surgery, Oral , Oral Medicine , PrevalenceABSTRACT
El mucocele oral es una lesión de los tejidos blandos con alta prevalencia en la cavidad oral, siendo motivo de consulta dadas las alteraciones funcionales y es-téticas asociadas al mismo. Su etiología está relacionada con la alteración en las glándulas salivales, correspondiendo la localización más frecuente al labio inferior. Su tratamiento, aunque en la mayoría de los casos es expectante, consiste en la extirpación quirúrgica debido a que pue-den llegar a ser de tamaño considerable. A continuación se describe el caso de un paciente varón, de avanzada edad, que presenta un mucocele de gran tamaño localizado en el labio inferior, región en la que se practicó su remoción quirúrgica y posterior análisis histopatológico
The oral mucocele is a soft tissue lesion with high prevalence in the oral cavity, the oral mucocele can be find associated with functional and aesthetic alterations. The etiology is related to the alteration in the salivary glands, the most frequent location corresponding to the lower lip. The treatment consists in surgical removal because they can be of considerable size. The following describes the case of a male patient, of advanced age, who has a large mucocele located in the lower lip, a region in which surgical removal was performed and subsequent histopathological análisis
