ABSTRACT
This is a case report of a 69-year-old male patient referred to the ENT out patients with right-sided epistaxis and hipoacusis. Fibroptic examination reveals a cystic lesion at the exit of the right eustachian. A CT scan is informed as a well delimited and rounded-shaped tumour compatible with lymphoma. Excisional biopsy by a nasal rigid endoscopy is practiced and the histology result is Warthin's tumour. The nasopharynx is a rather unusual location for this type of tumours, almost exclusive in origin of major salivary glands. It's highlighted the unforeseeable histological diagnosis in this particular anatomical region, where the clinical differential diagnosis is broad and the access difficult.
Subject(s)
Adenolymphoma/diagnostic imaging , Adenolymphoma/pathology , Choristoma/diagnostic imaging , Choristoma/pathology , Nasopharyngeal Neoplasms/diagnostic imaging , Nasopharyngeal Neoplasms/pathology , Nasopharynx , Adenolymphoma/surgery , Aged , Choristoma/surgery , Humans , Magnetic Resonance Imaging , Male , Nasopharyngeal Neoplasms/surgery , RadiographyABSTRACT
Se presenta el caso clínico de un varón de 69 años, que es referido a consultas externas de ORL con epístaxis de repetición e hipoacusia derechas. La exploración fibroscópica demuestra una lesión de aspecto quístico en el rodete tubárico derecho. Se solicita TAC que se informa de tumoración redondeada y bien delimitada compatible con linfoma. Se practica biopsia excisional mediante abordaje endoscópico nasal y el resultado histológico es de tumor de Warthin. La nasofaringe es una localización inusual para este tipo de patología, casi exclusiva de las glándulas salivales mayores. Se destaca la imprevisibilidad del diagnóstico anatomopatológico en un área anatómica "sui generis" donde el diagnóstico diferencial es extenso y difícil el acceso
This is a case report of a 69-year-old male patient referred to the ENT out patients with right-sided epistaxis and hipoacusis. Fibroptic examination reveals a cystic lesion at the exit of the right eustachian. A CT scan is informed as a well delimited and rounded-shaped tumour compatible with lymphoma. Excisional biopsy by a nasal rigid endoscopy is practiced and the histology result is Warthin´s tumour. The nasopharynx is a rather unusual location for this type of tumours, almost exclusive in origin of major salivary glands. It´s highlighted the unforeseeable histological diagnosis in this particular anatomical region, where the clinical differential diagnosis is broad and the access difficult
Subject(s)
Male , Aged , Humans , Adenolymphoma/pathology , Nasopharyngeal Neoplasms/pathology , Epistaxis/etiology , Hearing Loss/etiology , Diagnosis, DifferentialABSTRACT
Hypohidrotic Ectodermal Dysplasia (HED) is a rare recesive genetic disease linked to chromosome X whose main characteristic is the reduction of sweat glands, leading to a deficient sweating and an increase in body temperature. In HED mainly the ectodermal structures are involved such, as epidermis and its anexes (hair and nails), although non-ectodermal tissue may also become involved. Otolaryngologicalmanifestations are related to hypoplasia of the mucous glands of the upper aerodigestive tract, as chronic infections, like rhinitis, pharyngitis, bronchitis and otitis, and also epistaxis, dysphagia, anodontia and, ozena, among others. A case of a young adult male affected with HED who is referred to the Otolaryngology Departament with a history of chronic pharyngitis and ozena, is presented and the literature reviewed.
Subject(s)
Ectodermal Dysplasia/diagnosis , Adult , Ectodermal Dysplasia/complications , Humans , Male , Otorhinolaryngologic Diseases/etiology , Tomography, X-Ray ComputedABSTRACT
La Displasia Ectodérmica Hipohidrótica (DEH) esuna rara enfermedad genética recesiva ligada al cromosoma X, que se caracteriza porque produce la afectación de estructuras derivadas principalmente del ectodermo, como piel y anejos (pelo y uñas), aunque tejidos no-ectodérmicos también pueden verse comprometidos. El cuadro clínico está dominado por la disminución del número de glándulas sudoríparas y sus más inmediatas consecuencias, escasa sudoración y aumento de la temperatura corporal. Las manifestaciones otorrinolaringológicas derivan de la hipoplasia de las glándulas mucosas del tracto aerodigestivo superior, y destacan por la frecuencia de presentación las infecciones crónicas, como rinitis, faringitis y otitis, y también epistaxis, disfagia, anodontia y ocena, entre otras. Se presenta el caso clínico de un paciente varón joven con DEH que se remite al Servicio de Otorrinolaringología con clínica de faringitis crónica y ocena, y a propósito del cual se revisa la bibliografía
Hypohidrotic Ectodermal Dysplasia (HED) is a rare recesive genetic disease linked to chromosome X whose main characteristic is the reduction of sweat glands, leadingto a deficient sweating and an increase in body temperature. In HED mainly the ectodermal structures are involved such, as epidermis and its anexes (hair and nails), although non ectodermal tissue may also become involved. Otolaryngological manifestations are related to hypoplasia of the mucousglands of the upper aerodigestive tract, as chronic infections, like rhinitis, pharyngitis, bronchitis and otitis, and also epistaxis, dysphagia, anodontia and, ozena, among others. A case of a young adult male affected with HED who is referred to the Otolaryngology Departament with a history of chronic pharyngitis and ozena, is presented and the literature reviewed
Subject(s)
Male , Adult , Humans , Ectodermal Dysplasia , Anodontia/etiology , Rhinitis/etiology , Tomography, X-Ray Computed/methods , Biopsy , Skin/pathology , Sweat Glands/abnormalitiesABSTRACT
Se presenta un caso de metástasis de carcinoma papilar de tiroides de localización en el espacio parafaríngeo con clínica inicial de características obstructivas a nivel locorregional (disfagia progresiva y desviación contralateral de la amígdala correspondiente). En el estudio de imagen (TAC y RNM), la masa adoptaba una morfología especial, pero el diagnóstico no se confirmó hasta que se realizó el estudio anatomopatológico. Este espacio no es un lugar frecuente de asiento de metástasis ni de carcinomas tiroideos ni del resto de tumores de cabeza y cuello, por lo que, hasta la fecha, sólo se han descrito 5 casos similares en la literatura médica
This is a case report of a papillary thyroid carcinoma metastatic to the parapharyngeal space, that presented with local obstructive symptoms (dysphagia and displacement of the ipsilateral tonsil). The diagnosis was suspected by imaging studies (CT and MRI) but not confirmed until histological examination. It is not common for such tumors to metastasize to the parapharyngeal space. This is the reason why, to our knowledge, there have been described only five similar cases previously
Subject(s)
Female , Adult , Humans , Thyroid Neoplasms/complications , Pharyngeal Neoplasms/secondary , Carcinoma, Papillary/pathology , Thyroidectomy , Neoplasm Metastasis/pathologyABSTRACT
Laryngeal presentation of Malignat Fibrous Histiocytoma (MFH) is uncommon. It is more prevalent in elderly males. The most frequent form of laryngeal presentation is as subepithelial nodules, and its clinical behaviour is variable and unpredictable. Microscopically, it is a tumour with two well differentiated components: histiocitic and fibroblastic, with several different structural patterns that can make histologic diagnosis a difficult one. We present two cases of MFH of the larynx, and a review of the literature.
Subject(s)
Histiocytoma, Benign Fibrous , Laryngeal Neoplasms , Aged , Histiocytoma, Benign Fibrous/diagnosis , Humans , Laryngeal Neoplasms/diagnosis , Male , Middle AgedABSTRACT
El fibrohisticitoma (FHM) es una tumoración infrecuente en cabeza y cuello, y todavía mas en la laringe. Es más prevalente en varones de mediana edad, pudiendo aparecer a cualquier edad. la presentación más habitual laringea es en forma de nódulos subepiteliales. el comportamiento clínico es variable e impredecible. Microscópicamente, es un tumor con dos componentes diferenciados: histiocítico y fibroblástico, con diferentes patrones estructurales que pueden dificultar el diagnostico histológico. Se presentan dos casos de FHM laríngeos y se revisa la bibliografía(AU)
Laryngeal presentation of Malignat Fibrous Histiocytoma (MFH) is uncommon. It is more prevalent in elderly males. The most frequent form of laryngeal presentation is as subepithelial nodules, and its clinical behaviour is variable and unpredictable. Microscopically, it is a tumour with two well differentiated components: histiocitic and fibroblastic, with several different structural patterns that can make histologic diagnosis a difficult one. We present two cases of MFH of the larynx, and a review of the literature (AU)
Subject(s)
Humans , Aged , Male , Middle Aged , Histiocytoma, Malignant Fibrous/diagnosis , Laryngeal Neoplasms/pathologyABSTRACT
In the present study we review ENT tumor pathology in childhood. Only the most salient aspects are emphasized and the variety of entities reviewed was restricted. Molecular biology techniques reveal infection by human papilloma virus (types 6 and 11) in 50 % of papillomas, while immunohistochemical techniques are less effective in papilloma virus detection. The myofibroblastic nature of nasal angiofibroma has been demonstrated and its incidence is 25 times more frequent in patients with familial polyposis of the colon. Overexpression of p53 occurs in the initial stages of nasopharyngeal carcinoma, while overexpression of c-myc is correlated with an unfavorable prognosis. Recently, olfactory neuroblastoma has been shown not to express the protein product of the MIC-2 gene (antibody 12E7), thus the hypothesis that it could be a member of the Ewing tumor family (neuroectodermal peripheral tumors) has not been confirmed, although it is a primitive neural tumor. The head and neck rhabdomyosarcoma with the best prognosis is that located in the orbit, and cytogenetic studies have shown chromosomic translocation t(2;13) in 50 % of these childhood tumors when they are of the alveolar-type, while trisomy of chromosome 2 or 20 is more characteristic of the embryonic-type. Currently, any classifying features of ENT lymphomas must be based on the Revised European-American Classification of Lymphoid Neoplasms (REAL). Papillary and medullary carcinomas are the most common histological types of thyroid carcinoma in childhood. Alterations in ret/PTC play a significant role in the pathogenesis of both.
Subject(s)
Carcinoma/pathology , Laryngeal Neoplasms/pathology , Mouth Neoplasms/pathology , Nasopharyngeal Neoplasms/pathology , Papilloma/pathology , Pharyngeal Neoplasms/pathology , Thyroid Neoplasms/pathology , Adolescent , Angiofibroma/epidemiology , Angiofibroma/pathology , Carcinoma/epidemiology , Child , Child, Preschool , Diagnosis, Differential , Esthesioneuroblastoma, Olfactory/epidemiology , Esthesioneuroblastoma, Olfactory/pathology , Humans , Laryngeal Neoplasms/epidemiology , Laryngeal Neoplasms/virology , Lymphoma/epidemiology , Lymphoma/pathology , Mouth Neoplasms/epidemiology , Nasopharyngeal Neoplasms/epidemiology , Papilloma/epidemiology , Papilloma/virology , Papillomaviridae/isolation & purification , Pharyngeal Neoplasms/epidemiology , Pharyngeal Neoplasms/virology , Rhabdomyosarcoma/epidemiology , Rhabdomyosarcoma/pathology , Thyroid Neoplasms/epidemiologyABSTRACT
En el presente trabajo se revisa la patología tumoral otorrinolaringológica propia de la infancia. Se incide sólo en aquellos aspectos más sobresalientes, pues la variedad de entidades en estudio es restringida. En el 50 por ciento de los papilomas puede demostrarse la infección por virus del papiloma humano (tipos 6 y 11) mediante técnicas de biología molecular, siendo menor la capacidad demostrativa de la inmunohistoquímica. En el angiofibroma nasal se ha puesto en evidencia la naturaleza miofibroblástica y su incidencia es 25 veces más frecuente en poblaciones de pacientes con poliposis adenomatosa familiar del colon. En el carcinoma nasofaríngeo ocurre sobreexpresión de p53 en los estadios iniciales y la sobreexpresión de c-myc se correlaciona con peor pronóstico. Recientemente se ha demostrado que el neuroblastoma olfatorio no expresa la proteína producto del gen MIC2 (anticuerpo 12E7), por lo que no se confirma la hipótesis de que puede ser miembro de la familia del tumor de Ewing (tumores neuroectodérmicos periféricos), aunque sí es un tumor neural primitivo. El rabdomiosarcoma de cabeza y cuello con mejor pronóstico es el orbitario, y los estudios citogenéticos han señalado la translocación cromosómica t(2;13) en el 50 por ciento de estos tumores infantiles cuando son de tipo alveolar, mientras que la trisomía del cromosoma 2 o del 20 es más peculiar del tipo embrionario. Por otro lado, cualquier asunto clasificatorio de los linfomas del área otorrinolaringológica, actualmente tiene que basarse en la clasificación REAL (Revised European-American Classification of Lymphoid Neoplasms).Entre los tipos histológicos de carcinoma de tiroides, el papilar y el medular son los que más relieve poseen en la edad infantil y en la génesis de ambos, las alteraciones del protooncogén ret desempeñan un papel importante (AU)
Subject(s)
Child , Child, Preschool , Adolescent , Humans , Esthesioneuroblastoma, Olfactory , Angiofibroma , Papilloma , Rhabdomyosarcoma , Carcinoma , Diagnosis, Differential , Lymphoma , Thyroid Neoplasms , Papillomaviridae , Nasopharyngeal Neoplasms , Mouth Neoplasms , Pharyngeal Neoplasms , Laryngeal NeoplasmsSubject(s)
Esophagus , Foreign Bodies/diagnostic imaging , Pharynx , Adult , Algorithms , Female , Foreign Bodies/surgery , Humans , RadiographyABSTRACT
Carotid glomus tumours compose an infrequent clinical group. The presence of familiar forms, multicentric or with secretory characteristics hinder the diagnosis. A high suspicion rate based on the clinical picture and supported by imaging techniques will allow in each case to proceed with the more suitable treatment. The case reported refers to a woman with a carotid body glomus possibly of endocrine nature, which evolved favourable despite the therapeutical avoidance due to the peculiar features of the case.
Subject(s)
Carotid Body Tumor/diagnostic imaging , Aged , Aged, 80 and over , Angiography , Female , Humans , Tomography, X-Ray Computed , UltrasonographyABSTRACT
Radiation-associated (RA) osteosarcomas (OS) are exceptional in children, presenting more frequently in middle-aged and elderly patients. This is a case report of RA-OS of the sinonasal cavities in a 13-yr-old girl after combined therapy for rhabdomyosarcoma (RMS) of the nose diagnosed at the age of five. The treatment of choice is radical surgery with wide margins and postoperative adjuvant chemotherapy and radiotherapy. Despite an episode of recurrence, at the present time the patient is alive and free of disease 5 yr after the initial treatment of OS. The association between radiation, chemotherapy and sarcomas is reviewed and discussed.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Neoplasms, Radiation-Induced/etiology , Nose Neoplasms/drug therapy , Nose Neoplasms/rehabilitation , Osteosarcoma/etiology , Paranasal Sinus Neoplasms/etiology , Radiotherapy/adverse effects , Rhabdomyosarcoma/drug therapy , Rhabdomyosarcoma/rehabilitation , Adolescent , Combined Modality Therapy , Female , Humans , Immunohistochemistry , Neoplasm Recurrence, Local , Nose Neoplasms/diagnosis , Osteosarcoma/diagnosis , Paranasal Sinus Neoplasms/diagnosis , Radiation Dosage , Rhabdomyosarcoma/pathology , Tomography, X-Ray ComputedABSTRACT
No disponible
Subject(s)
Child, Preschool , Male , Humans , Thyroglossal Cyst , Tongue Diseases , Cutaneous Fistula , FistulaABSTRACT
No disponible
Subject(s)
Aged , Male , Humans , Paraganglia, Nonchromaffin , Ear Diseases , Hemorrhage , Hypertension , Glomus Jugulare TumorSubject(s)
Calculi/diagnostic imaging , Nose Diseases/diagnostic imaging , Adult , Female , Humans , Radiography , Suppuration , Time FactorsABSTRACT
No disponible
Subject(s)
Adult , Female , Humans , Thyroglossal Cyst , Diagnosis, DifferentialABSTRACT
El adenoma pleomorfo es el tumor benigno más común de todas las neoplasias de glándulas salivares, representando el 65 por ciento de todos los tumores de estas localizaciones, afectando sobre todo a la parótida. Puede aparecer también en otras glándulas salivares mayores y menores del tracto aerodigestivo superior.Presentamos dos casos de adenomas localizados en tabique nasal y paladar blando, señalando las características clínicas y diagnósticas de nuestros pacientes, así como la terapéutica aplicada.Exponemos los aspectos más importantes de esta entidad en el momento actual (AU)
Subject(s)
Adult , Female , Male , Middle Aged , Humans , Salivary Glands, Minor/surgery , Salivary Glands, Minor/pathology , Adenoma, Pleomorphic/surgery , Adenoma, Pleomorphic/complications , Adenoma, Pleomorphic/diagnosis , Adenoma, Pleomorphic , Salivary Gland Neoplasms/surgery , Salivary Gland Neoplasms/complications , Salivary Gland Neoplasms/diagnosis , Salivary Gland Neoplasms/etiology , Neoplasm Invasiveness/pathology , Tomography, X-Ray Computed/methods , Tomography, X-Ray Computed , Neoplasm Metastasis , Nasal Septum/surgery , Nasal Septum/pathologyABSTRACT
Realizamos un estudio retrospectivo de los tumores malignos nasosinusales diagnosticados en nuestro Servicio en los últimos cinco años. Analizamos su forma de presentación, tipos histológicos, localización, tratamiento y evolución, y finalizamos con una revisión bibliográfica de los aspectos más relevantes de estas neoplasias. (AU)
