[The characteristics of the action of ethacizine and its combination with digoxin and glutamic acid on the hemodynamic indices and myocardial contractile capacity in patients with a heart rhythm disorder]. / Osobennosti deistviia étatsizina i ego kombinatsii s digoksinom i glutaminovoi kislotoi na pokazateli gemodinamiki i sokratitel'nuiu sposobnost' miokarda u bol'nykh s narusheniem serdechnogo ritma.

A study was made of the effect of ethacizine administered in a single dose and continuously on myocardial contractility and hemodynamics in 78 patients with coronary heart disease, neurocirculatory dystonia and myocardiodystrophy suffering from impaired cardiac rhythm. In 28 patients, ethacizine was administered in combination with glutamic acid and in 23 with digoxin. In patients with coronary heart disease, particularly in those with heart failure, ethacizine produced a negative inotropic effect. Introduction into the treatment of digoxin or glutamic acid smoothed over the cardiodepressive action of the drug. When administered continuously in a dose of 150-300 mg/day, ethacizine is an effective antiarrhythmic drug.

[Soluble proteins of the vegetative cells and spores of Clostridium botulinum type B and their toxicity]. / Rastvorimye belki vegetativnykh kletok i spor Clostridium botulinum tipa B i ikh toksichnost'

By disc microelectrophoresis in polyacrylamide gel proteins of vegetative cells and spores of Clostridium botulinum type B were investigated at different growth phases and toxicity of protein zones was measured. Protein components of vegetative cells varied in their electrophoretic mobility, depending on the growth phase, and differed significantly from spore proteins. Spores contained 1% toxin of vegetative cells. Electrophoregrams of intrasporal proteins showed a toxic zone with an approximate molecular weight of 10(5)-10(6).