Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Language
Publication year range
1.
J. med. virol ; 94(1): 178-185, 2022. tab, graf
Article in English | Coleciona SUS, Sec. Est. Saúde SP, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO | ID: biblio-1393242

ABSTRACT

Many aspects of the humoral immune response to severe acute respiratory syn-drome coronavirus 2 (SARS­CoV­2), such as its role in protection after natural in-fection, are still unclear. We evaluated IgA and IgG response to spike subunits 1 and2 (S1 and S2) and Nucleocapsid proteins of SARS­COV­2 in serum samples of 109volunteers with viral RNA detected or seroconversion with different clinical evolu-tion (asymptomatic, mild, moderate, and severe coronavirus disease 2019), using theViraChip®Test Kit. We observed that the quantification of antibodies to all antigenshad a positive correlation to disease severity, which was strongly associated with thepresence of comorbidities. Seroreversion was not uncommon even during the short(median of 77 days) observation, occurring in 15% of mild­asymptomatic cases at amedian of 55 days for IgG and 46 days for IgA. The time to reach the maximalantibody response did not differ significantly among recovered and deceased vo-lunteers. Our study illustrated the dynamic of anti­S1, anti­N, and anti­S2 IgA andIgG antibodies, and suggests that high production of IgG and IgA does not guaranteeprotection to disease severity and that functional responses that have been studiedby other groups, such as antibody avidity, need further attention. (AU)


Subject(s)
Nucleocapsid , Protein Array Analysis , Spike Glycoprotein, Coronavirus , SARS-CoV-2 , COVID-19
SELECTION OF CITATIONS
SEARCH DETAIL
...