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1.
Parasitol Res ; 123(1): 75, 2023 Dec 29.
Article in English | MEDLINE | ID: mdl-38155300

ABSTRACT

The development of new antimalarials is paramount to keep the goals on reduction of malaria cases in endemic regions. The search for quality hits has been challenging as many inhibitory molecules may not progress to the next development stage. The aim of this work was to screen an in-house library of heterocyclic compounds (HCUV) for antimalarial activity combining computational predictions and phenotypic techniques to find quality hits. The physicochemical determinants, pharmacokinetic properties (ADME), and drug-likeness of HCUV were evaluated in silico, and compounds were selected for structure-based virtual screening and in vitro analysis. Seven Plasmodium target proteins were selected from the DrugBank Database, and ligands and receptors were processed using UCSF Chimera and Open Babel before being subjected to docking using Autodock Vina and Autodock 4. Growth inhibition of P. falciparum (3D7) cultures was tested by SYBR Green assays, and toxicity was assessed using hemolytic activity tests and the Galleria mellonella in vivo model. From a total of 792 compounds, 341 with good ADME properties, drug-likeness, and no interference structures were subjected to in vitro analysis. Eight compounds showed IC50 ranging from 0.175 to 0.990 µM, and active compounds included pyridyl-diaminopyrimido-diazepines, pyridyl-N-acetyl- and pyridyl-N-phenyl-pyrazoline derivatives. The most potent compound (UV802, IC50 0.178 µM) showed no toxicophoric and was predicted to interact with P. falciparum 1-cysperoxidredoxin (PfPrx1). For the remaining 7 hits (IC50 < 1 µM), 3 showed in silico binding to PfPrx1, one was predicted to bind the haloacid dehalogenase-like hydrolase and plasmepsin II, and one interacted with the plasmodial heat shock protein 90.


Subject(s)
Antimalarials , Malaria, Falciparum , Malaria , Humans , Antimalarials/therapeutic use , Plasmodium falciparum , Malaria/drug therapy , Malaria, Falciparum/drug therapy , Molecular Docking Simulation
2.
Rev. esp. enferm. dig ; 112(12): 921-924, dic. 2020. graf, tab
Article in Spanish | IBECS | ID: ibc-200580

ABSTRACT

INTRODUCCIÓN: se ha observado que la ablación endoscópica por radiofrecuencia en tumores irresecables de vía biliar prolonga la sobrevida. OBJETIVO: evaluar sobrevida, permeabilidad de prótesis y efectos adversos de la ablación contra un grupo control. METODOLOGÍA: estudio observacional en pacientes con estenosis biliar maligna irresecable. RESULTADOS: cuarenta pacientes, 12 radiofrecuencia, no hubo diferencias entre variables basales de ambos grupos. Hubo mayor sobrevida en el grupo de radiofrecuencia sin diferencia estadísticamente significativa (217 vs. 129 días, log-rank 0,31). No hubo diferencia en permeabilidad de prótesis o efectos adversos. CONCLUSIÓN: se encontró ganancia de tres meses en sobrevida a favor de la radiofrecuencia sin alcanzar diferencia estadísticamente significativa


No disponible


Subject(s)
Humans , Female , Middle Aged , Radiofrequency Ablation/methods , Treatment Outcome , Catheter Ablation/methods , Bile Duct Diseases/surgery , Cholangiopancreatography, Endoscopic Retrograde , Progression-Free Survival , Catheter Ablation/instrumentation , Bile Duct Neoplasms/surgery , Radiofrequency Ablation/adverse effects , Prospective Studies
3.
Rev Esp Enferm Dig ; 112(12): 921-924, 2020 Dec.
Article in English | MEDLINE | ID: mdl-33179512

ABSTRACT

INTRODUCTION: previous studies have shown that endoscopic radiofrequency ablation in unresectable biliary duct tumors prolongs survival. METHODS: this was an observational study of patients with an unresectable malignant stricture. The aim was to evaluate survival, stent patency and adverse events of radiofrequency compared with a matched control group. RESULTS: the study included 40 patients, 12 with radiofrequency. There were no differences between baseline parameters in both groups. The survival time was longer in the radiofrequency group with no statistically significant difference (217 vs 129 days, log-rank 0.31). There was no difference in stent permeability or adverse events. CONCLUSION: the radiofrequency group had a three-month increase in survival, which did not reach statistical significance.


Subject(s)
Bile Duct Neoplasms , Catheter Ablation , Cholestasis , Radiofrequency Ablation , Bile Duct Neoplasms/surgery , Cholestasis/etiology , Cholestasis/surgery , Constriction, Pathologic/etiology , Constriction, Pathologic/surgery , Humans , Stents , Treatment Outcome
4.
Prev Chronic Dis ; 17: E04, 2020 01 09.
Article in English | MEDLINE | ID: mdl-31922370

ABSTRACT

PURPOSE AND OBJECTIVES: Although food insecurity is associated with poor dietary intake and risk of chronic disease, few studies have demonstrated the effectiveness of diabetes prevention interventions delivered through food banks. Food banks serve vulnerable communities. The purpose of this pilot project was to assess the effectiveness of a food bank-delivered intervention aimed at improving food security and reducing risk factors for type 2 diabetes among at-risk clients. INTERVENTION APPROACH: We screened adult English- and Spanish-speaking food bank clients for type 2 diabetes risk at 12 community food distribution sites in Alameda County, California. Screening and enrollment for a pilot intervention took place from November 2017 to March 2018. Intervention components were delivered from November 2017 through March 2019. The intervention included monthly diabetes-appropriate food packages, text-based health education, and referrals to health care. EVALUATION METHODS: Food bank staff members administered surveys to participants at baseline, 6 months (midpoint), and 12 months (postintervention); participants self-reported all responses. Primary outcomes assessed were food security status, dietary intake, health-related behaviors, and body mass index (BMI). Information on demographic characteristics, food pantry access, health care use, and symptoms of depression was also collected. RESULTS: We screened 462 food bank clients for eligibility. Of the 299 who were eligible, 244 enrolled; 90.6% were female, 80.1% were Hispanic, and 49.1% had an annual household income less than $20,000. At baseline, 68.8% of participants had low or very low food security. At midpoint, participants had significant improvements in food security status, dietary intake, physical activity, health status, and depression scores. Mean BMI did not change. IMPLICATIONS FOR PUBLIC HEALTH: This intervention demonstrated that food banks can effectively screen clients at high risk for diabetes and improve household food security and other risk factors for diabetes. Food banks may be an important and strategic partner for health care systems or community-based organizations working to prevent diabetes in food-insecure populations.


Subject(s)
Diabetes Mellitus, Type 2/prevention & control , Food Assistance/organization & administration , Food Insecurity , Adult , Body Mass Index , California , Exercise , Female , Food/statistics & numerical data , Food Assistance/statistics & numerical data , Health Status , Humans , Male , Middle Aged , Pilot Projects , Program Evaluation , Risk Factors , Surveys and Questionnaires
5.
Ciudad, México; s.n; s.n; 20140609. 1-87 p. PDF tab. (000715132).
Thesis in Spanish | BDENF - Nursing, LILACS | ID: biblio-1150592

ABSTRACT

La gran cantidad de información difundida a partir de la aparición del virus de la influenza A (H1N1) en todo el mundo ocasionó diversidad de información para el manejo de los pacientes; así como numerosas investigaciones en torno al tema, enfocándose principalmente en la prevención y tratamiento de la Influenza A (H1N1), obteniendo buenos resultados; sin embargo un número importante de pacientes se complican enfrentando un proceso de neumonía, Síndrome de Insuficiencia Respiratoria Aguda (SIRA) y otras afecciones agregadas, requiriendo así de hospitalización en una Unidad de Cuidados Intensivos (UCI) y ocasionando un costo muy elevado para la atención especializada Ante esta situación resulta invaluable la creación de instrumentos confiables que permitan otorgar al paciente la atención oportuna, así como la implementación de prácticas seguras que permitan al profesional de enfermería otorgar un cuidado de calidad. Las guías clínicas son instrumentos confiables que ofrecen instrucciones claras y explicitas, basadas en la mejor evidencia disponible; lo que permite homogeneizar las intervenciones, evitar variabilidad en los cuidados y garantizar una atención de calidad. Un elemento clave de las GPC es que incorporan recomendaciones basadas en la evidencia, lo que significa que proceden de revisiones sistemáticas o de paneles de expertos y técnicas de consenso. Objetivo: Elaborar una Guía de Práctica Clínica de Enfermería para la atención del paciente adulto con influenza A (H1N1) en la Unidad de Cuidados Intensivos. Metodología: Para la elaboración de la guía se llevó a cabo la revisión de la literatura sobre los aspectos generales, antecedentes epidemiológicos, fisiopatológicos de la Influenza A (H1N1), se realizó una revisión sistemática de las bases de datos en Cochrane Library, Medline, Scielo, Embase; se aplicaron 25 valoraciones a pacientes con influenza A H1N1 (casos confirmados) de acuerdo a las 14 necesidades básicas según la filosofía de Virginia Henderson, identificando principalmente las necesidades que estaban más alteradas, para posteriormente identificar las etiquetas diagnosticas de la North American Nursing Diagnosis Association (NANDA) que se emplearían para su uso y finalmente describir las intervenciones basadas en la evidencia científica y recomendaciones consideradas como "buena práctica" por el consenso de expertos. Resultados: De acuerdo a los resultados obtenidos, las necesidades más alteradas de acuerdo a la filosofía de Virginia Henderson son: oxigenación, nutrición e hidratación, termorregulación, higiene y protección a tegumentos. Posteriormente se identifican las etiquetas diagnosticas de la NANDA y se describen las intervenciones que realiza el profesional de enfermería en la unidad de cuidados intensivos basadas en la evidencia científica y otras como recomendaciones en el consenso de expertos. Conclusiones: Se pretende que la propuesta de esta guía clínica sirva de una valiosa herramienta en la consulta de las intervenciones que se han de ejecutar en los pacientes adultos con influenza A (H1N1) y permita formar un pensamiento crítico y reflexivo en la toma de decisiones, al tiempo que favorece la autonomía en el profesional de enfermería.


The large amount of information transmitted from the emergence of influenza A (H1N1) virus caused worldwide diversity of information for the management of patients; and extensive research on the subject, focusing on the prevention and treatment of influenza A (H1N1), with good results; however, a significant number of patients facing a complicated process pneumonia, Acute Respiratory Distress Syndrome (ARDS) and other aggregate conditions, thus requiring hospitalization in an intensive care unit (ICU ) and causing a very high cost for care specialized. In this situation it is invaluable to create reliable instruments to provide timely patient care and the implementation of safe practices to nursing professionals provide quality care. Clinical guidelines are reliable instruments that offer clear and explicit instructions, based on the best available evidence; allowing standardizes interventions, avoid variability in care and ensure quality care. A key element of the GPC is incorporating evidence-based recommendations, meaning that come from systematic reviews or expert panels and consensus techniques. Objective: Develop a Clinical Nursing Practice for the care of adult patients with influenza A (H1N1) in the Intensive Care Unit. Methodology: In preparing the guide conducted the review of the literature on general aspects, epidemiological history, pathophysiologic Influenza A ( H1N1), a systematic review of the databases in the Cochrane Library, Medline, SciELO was performed, Embase; 25 ratings were applied to patients with influenza A H1N1 (confirmed cases) according to the 14 basic needs according to Virginia Henderson's philosophy, primarily identifying the needs that were most affected, to further identify the diagnostic labels North American Nursing Diagnosis Association (NANDA) to be employed for use and finally describe interventions based on scientific advice and considered "best practice" by the consensus of expert evidence. Results: According to the results, the most altered needs according to Virginia Henderson's philosophy are: oxygenation, nutrition and hydration, thermoregulation, hygiene and protection integument. Subsequently the NANDA diagnostic labels are identified and interventions made by the nurse in the intensive care unit based on scientific evidence and other recommendations as expert consensus described. Conclusions: It is intended that the proposal of these guidelines will serve as a valuable tool in the consultation of the interventions that have been running in adult patients with influenza A H1N1 and allowed to form a critical and reflective thinking in decision making, while favors autonomy in professional nursing .


A grande quantidade de informações disseminadas desde o início do vírus influenza A (H1N1) em todo o mundo causou uma variedade de informações para o gerenciamento de pacientes; além de inúmeras investigações sobre o assunto, com foco principalmente na prevenção e tratamento da Influenza A (H1N1), obtendo bons resultados; no entanto, um número significativo de pacientes é complicado ao enfrentar um processo de pneumonia, Síndrome da Insuficiência Respiratória Aguda (SIRA) e outras condições agregadas, exigindo hospitalização em uma Unidade de Terapia Intensiva (UTI) e causando um custo muito alto para o atendimento especializado Diante dessa situação, é inestimável a criação de instrumentos confiáveis ​​que possibilitem o atendimento oportuno ao paciente, bem como a implementação de práticas seguras que permitam ao profissional de enfermagem prestar atendimento de qualidade. As diretrizes clínicas são instrumentos confiáveis ​​que oferecem instruções claras e explícitas, com base nas melhores evidências disponíveis; o que permite homogeneizar as intervenções, evitar variabilidade no atendimento e garantir atendimento de qualidade. Um elemento-chave dos CPGs é que eles incorporam recomendações baseadas em evidências, o que significa que provêm de revisões sistemáticas ou painéis de especialistas e técnicas de consenso. Objetivo: Prepare um Guia de Prática Clínica de Enfermagem para o atendimento de pacientes adultos com influenza A (H1N1) na Unidade de Terapia Intensiva. Metodologia: Para a elaboração do guia, foi realizada uma revisão da literatura sobre aspectos gerais, antecedentes epidemiológicos e fisiopatológicos da Influenza A (H1N1), uma revisão sistemática das bases de dados na Biblioteca Cochrane, Medline, Scielo, Embase; Foram aplicadas 25 avaliações em pacientes com influenza A H1N1 (casos confirmados) de acordo com as 14 necessidades básicas de acordo com a filosofia de Virginia Henderson, identificando principalmente as necessidades que foram mais alteradas, para posteriormente identificar os rótulos de diagnóstico da North American Nursing Diagnosis Association (NANDA) que seria usado para seu uso e, finalmente, descreveria as intervenções baseadas em evidências e recomendações científicas consideradas como "boas práticas" pelo consenso de especialistas. Resultados: De acordo com os resultados obtidos, as necessidades mais alteradas de acordo com a filosofia de Virginia Henderson são: oxigenação, nutrição e hidratação, termorregulação, higiene e proteção de tegumento. Posteriormente, são identificados os rótulos diagnósticos da NANDA e descritas as intervenções realizadas pelo profissional de enfermagem na unidade de terapia intensiva, com base em evidências científicas e outras, conforme recomendações no consenso de especialistas. Conclusões: Pretende-se que a proposta deste guia clínico sirva como uma ferramenta valiosa na consulta das intervenções a serem realizadas em pacientes adultos com influenza A (H1N1) e permita formar um pensamento crítico e reflexivo na tomada de decisão, por tempo que favorece a autonomia do profissional de enfermagem.


Subject(s)
Humans , Influenza Pandemic, 1918-1919
6.
Rev. enferm. Inst. Mex. Seguro Soc ; 14(1): 35-39, Enero.-Abr. 2006. tab
Article in Spanish | LILACS, BDENF - Nursing | ID: biblio-968635

ABSTRACT

Objetivo: Describir el nivel de conocimiento del personal de enfermería sobre el procedimiento de diálisis peritoneal con bolsa gemela. Metodología: Se realizó un estudio transversal, con un instrumento de evaluación de conocimiento teórico de diálisis peritoneal a 110 enfermeras seleccionadas al azar en las categorías directivo 7, especialista 10, generales 57 y auxiliares 36; y una lista de cotejo para evaluar a 53 enfermeras en habilidades y destrezas en el cambio de bolsa gemela. Resultados: El conocimiento fue muy bueno en 33%, bueno 59% y malo 9%. No se encontró diferencias en el nivel de conocimiento por categorías, turno, antigüedad ni escuela de procedencia, así como asistencia a sesiones de capacitación. El grado de conocimiento se asoció al antecedente de haber realizado cambio de bolsa, turno y tiempo de laborar en diálisis peritoneal. De los 53 participantes se obtuvo una calificación media de 60.8 de un máximo de 80 puntos con un nivel regular en la destreza para el procedimiento de cambio de bolsa gemela. Conclusiones: El nivel de conocimiento del procedimiento de diálisis peritoneal se considera bueno, sin embargo su habilidad para el cambio es regular, no encontramos correlación entre el nivel de conocimiento y la destreza. Influye más para el conocimiento teórico y práctico el haber laborado en el servicio de diálisis y/o haber realizado cambio de línea, que la capacitación otorgada en sesiones.


Objective: To describe nursing staff's knowledge level about peritoneal dialysis procedure with twin bag. Methodology: A transversal study was done, with an instrument to assess theoretical knowledge about peritoneal dialysis to 110 randomly selected nurses within the categories: executive 7, specialized 10, professional 57, and assistant 36. Also, a check list was done to evaluate 53 nurses in abilities and skills for changing the twin bag. Results: Knowledge was 33% very good, 59% good and 9% bad. It were not found differences in the knowledge level neither by categories, shift, length in the job, nor source school, as well as attendance to sessions of training. Knowledge level was associated to the antecedent of having changed the bag, time shift, and length of being working on peritoneal dialysis. From 53 participants, it was obtained an average score of 60.8 out of 80 points, with a regular level in the skill to do the procedure to change the twin bag. Conclusions: The knowledge level of peritoneal dialysis procedure is considered as good; however, the ability for changing the bag is evaluated as regular. It was not found correlation between knowledge level and skill. For the theoretical and practical knowledge, having worked in the dialysis service and having done the change of the line influenced more than having received training in sessions.


Subject(s)
Humans , Cross-Sectional Studies , Nursing , Peritoneal Dialysis , Clinical Competence , Nursing Process , Mexico
7.
Actual. enferm ; 6(2): 25-28, jun. 2003. ilus
Article in Spanish | LILACS | ID: lil-353301

ABSTRACT

El trasplante de médula ósea es una modalidad de tratamiento para una serie de enfermedades malignas y no malignas. Consiste en infundir células madre hematopoyéticas por vía intravenosa, después de una quimioterapia de altas dosis, para restablecer la hematopoyesis del paciente. La enfermera de trasplantes juega un papel importante durante todas las fases del proceso, brinda atención directa a los pacientes e imparte educación tanto a él como a su familia, con el fin de prevenir complicaciones y promover el autocuidado


Subject(s)
Bone Marrow Transplantation/classification , Bone Marrow Transplantation/methods
8.
Rev. invest. clín ; 44(1): 115-21, ene.-mar. 1992. ilus, tab
Article in English | LILACS | ID: lil-111016

ABSTRACT

Se describe un nuevo caso de la asociación de MURCS (aplasia de ductos müllerianos, aplasia renal y displasia de las somitas cérvico-torácicas) en un paciente de 18 años de edad. Además de presentar otras características fenotípicas alteradas, se documentó la presencia de anovulación crónica hipotalámica. Las concentraciones basales de prolactina, tirotrofina, hormona de crecimiento, cortisol y estradiol se encontraron dentro de los límites de referencia para mujeres adultas. A la estimulación con TRH y ACTH se observaron respuestas dentro de los límites de referencia en términos de tirotrofina y cortisol respectivamente. Las concentraciones basales de LH y FSH, así como la estimulación con LHRH, demostraron disociación de ambas gonadotropinas. Los valores basales de progesterona se encontraron, a lo largo de un mes, en concentraciones acordes con la fase folicular. Esto último condujo al diagnóstico de anovulación crónica hipotalámica la cual fue confirmada mediante la inducción de ovulación con citrato de clomifeno. Este hallazgo demuestra la importancia de llevar a cabo evaluaciones endocrinológicas detalladas en pacientes con el diagnóstico de MURCS, con el fin de prevenir y/o tratar alteraciones secundarias a deficiencias endocrinológicas


Subject(s)
Humans , Adolescent , Female , Abnormalities, Multiple , Anovulation/diagnosis , Adrenal Glands/abnormalities , Kidney/abnormalities , Cervical Vertebrae/abnormalities , Thoracic Vertebrae/abnormalities
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