ABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica de la proteína ciclina D1 (DCS6) en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante 5 años en el servicio ORL del Hospital «Virgen de la Salud» (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de ciclina DI a dicho nivel. Además se estudia el valor pronóstico de la expresión de ciclina D1 en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y se analiza la posible relación de dicha expresión con otros parámetros clínico-patológicos
In this paper we carried out an immunohistochemical study of cyclin D1 (DCS6) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at fue Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph nade metastasis we also studied cyclin D1 expression at this level. Furthermore we have analysed fue value of cyclin D1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between cyclin D1 expression and other clinic and pathologic parameters
Subject(s)
Humans , Carcinoma, Squamous Cell/pathology , Cyclin D1/analysis , Laryngeal Neoplasms/pathology , Immunohistochemistry/methodsABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica del alproteína p27KIp1 en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante al menos 5 años en el servicio ORL del Hospita "Virgen de la Salud" (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de p27KIP1 a dicho nivel. Además se ha analizado el valor pronóstico de la expresión de p27KIP1 en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y estudiamos la posible relación de dicha expresión con otros parámetros clinicopatológicos
In this paper we carried out an immunohistochemical study of protein p27KIPI expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain). In the cases with lymph node metastasis we also studied p27KIPI expression at this level. Furthermore we have analysed the value of protein p27KIPI expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between p 27KIPI expression and other clinic and pathologic parameters
Subject(s)
Aged , Humans , Carcinoma, Squamous Cell/metabolism , Laryngeal Neoplasms/metabolism , Carcinoma, Squamous Cell/pathology , Immunohistochemistry , Phenotype , Prognosis , Neoplasm Staging , Laryngeal Neoplasms/pathologyABSTRACT
En este trabajo hemos estudiado la expresión inmuno-histoquímica de la proteína Rb (G3-245) en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante 5 años en el servicio ORL del Hospital «Virgen de la Salud» (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de Rb a dicho nivel. Además se analiza el valor pronóstico de la expresión de Rb en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y estudiamos la posible relación de dicha expresión con otros parámetros clinicopatológicos
In this paper we carried out an immunohistochemical study of protein p21WAF1 (EA 10) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain). In the cases with lymph node metastasis; we also studied p21WAF1 expression at this level. Furthermore we have analysed the value of protein p21WAF1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival (and we evaluate the relationship between p21WAF1 expression and other clinic and pathologic parameters. Keywords: p21WAFl Protein. Larynx cancerIn this paper we carried out an immunohistochemical study of bcl-2 protein expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo. Spain). In the cases with lymphonode metastasis we also analysed bcl-2 protein expression at this level. Furthermore we have studied the value of bcl-2 protein expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we analysed the relationship between bcl-2 protein expression and other clinic and pathologic parametersIn this paper we carried out an immunohistochemical study of protein Rb (G3-245) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied Rb expression at this level. Furthermore we have analysed the value of Rb expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between Rb expression and other clinic and pathologic parameters
Subject(s)
Humans , Retinoblastoma Protein/analysis , Laryngeal Neoplasms/pathology , Disease-Free Survival , Biomarkers, Tumor/analysis , Lymphatic Metastasis/pathology , Laryngeal Neoplasms/mortality , Neoplasm Metastasis/pathology , Neoplasm Recurrence, Local/epidemiologyABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica de la proteína p21WAF1 (EA10) en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante al menos 5 años en el servicio de ORL del Hospital Virgen de la Salud (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de p21WAF1 a dicho nivel. Además se ha analizado el valor pronóstico de la expresión de p21WAF1 en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y estudiamos la posible relación de dicha expresión con otros parámetros clínicopatológicos
In this paper we carried out an immunohistochemical study of protein p21WAF1 (EA 10) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain). In the cases with lymph node metastasis; we also studied p21WAF1 expression at this level. Furthermore we have analysed the value of protein p21WAF1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival (and we evaluate the relationship between p21WAF1 expression and other clinic and pathologic parameters. Keywords: p21WAFl Protein. Larynx cancerIn this paper we carried out an immunohistochemical study of bcl-2 protein expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo. Spain). In the cases with lymphonode metastasis we also analysed bcl-2 protein expression at this level. Furthermore we have studied the value of bcl-2 protein expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we analysed the relationship between bcl-2 protein expression and other clinic and pathologic parametersIn this paper we carried out an immunohistochemical study of protein Rb (G3-245) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied Rb expression at this level. Furthermore we have analysed the value of Rb expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between Rb expression and other clinic and pathologic parameters
Subject(s)
Aged , Humans , Carcinoma, Squamous Cell/metabolism , Cell Cycle Proteins/metabolism , Laryngeal Neoplasms/metabolism , Carcinoma, Squamous Cell/pathology , Immunohistochemistry , Prognosis , Neoplasm Staging , Laryngeal Neoplasms/pathologyABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica de la proteína bcl-2 en 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante 5 años en el servicio ORL del Hospital Virgen de la Salud (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de bcl-2 a dicho nivel. Además se ha estudiado el valor pronóstico de la expresión de bcl-2 en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y analizamod la posible relación de dicha expresión con otros parámetros clínicopatológicos
In this paper we carried out an immunohistochemical study of protein p21WAF1 (EA 10) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain). In the cases with lymph node metastasis; we also studied p21WAF1 expression at this level. Furthermore we have analysed the value of protein p21WAF1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival (and we evaluate the relationship between p21WAF1 expression and other clinic and pathologic parameters. Keywords: p21WAFl Protein. Larynx cancerIn this paper we carried out an immunohistochemical study of bcl-2 protein expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo. Spain). In the cases with lymphonode metastasis we also analysed bcl-2 protein expression at this level. Furthermore we have studied the value of bcl-2 protein expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we analysed the relationship between bcl-2 protein expression and other clinic and pathologic parametersIn this paper we carried out an immunohistochemical study of protein Rb (G3-245) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied Rb expression at this level. Furthermore we have analysed the value of Rb expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between Rb expression and other clinic and pathologic parameters
Subject(s)
Aged , Humans , Carcinoma, Squamous Cell/metabolism , Laryngeal Neoplasms/metabolism , Proto-Oncogene Proteins c-bcl-2/metabolism , Tumor Suppressor Protein p53/immunology , Antibodies, Monoclonal/immunology , Carcinoma, Squamous Cell/immunology , Immunohistochemistry , Prognosis , Neoplasm Staging , Laryngeal Neoplasms/immunology , Proto-Oncogene Proteins c-bcl-2/immunology , Tumor Suppressor Protein p53/metabolismABSTRACT
Estudiamos la expresión inmunohistoquímica de la proteína p53 (DO7) en una serie de 195 pacientes con el diagnóstico de carcinoma epidermoide de laringe, tratados y seguidos durante al menos 5 años en el servicio ORL del Hospital "Virgen de la Salud" (Toledo). En los casos con metástasis ganglionares, se valoró también la expresión de p53 a dicho nivel. Investigamos el valor de p53 como factor pronóstico (desarrollo de recidiva, muerte por cáncer y supervivencia) y analizamos la posible relación de dicha expresión de p53 con otros parámetros clínico-patológicos (AU)
Subject(s)
Male , Humans , Female , Aged , Prognosis , Neoplasm Invasiveness , Immunohistochemistry , Laryngeal Neoplasms , Neoplasm Staging , Tumor Suppressor Protein p53ABSTRACT
En este trabajo hemos estudiado la expresión inmunohistoquímica de la proteína Mdm-2 (IF2) en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante al menos 5 años en el servicio de ORL del Hospital "Virgen de la Salud" (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de Mdm-2 a este nivel. También hemos querido investigar el valor pronóstico de la expresión de Mdm-2 en este tipo de tumores (desarrollo de recidivas, mortalidad por cancer de laringe y supervivencia) y analizamos la posible relación de dicha expresión con otros parámetros clínicopatológicos (AU)
