Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Language
Publication year range
1.
Med. oral patol. oral cir. bucal (Internet) ; 24(3): e339-e345, mayo 2019. tab, ilus
Article in English | IBECS | ID: ibc-185642

ABSTRACT

Background: The exact pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is still unknown. The aim of this paper was to investigate the effects of zoledronic acid and dexamethasone on the early phases of socket healing in rats subjected to tooth extractions. Material and Methods: Thirty male Sprague-Dawley rats were divided into 2 groups: pharmacologically treated group (T, n = 20) and non-pharmacologically treated group (C, n=10). T group rats received 0.1 mg/Kg of zoledronic acid (ZOL) and 1 mg/Kg of dexamethasone (DEX) three times a week for 10 consecutive weeks. C group rats were infused with vehicle. After 9 weeks from the first infusion, first maxillary molars were extracted in each of the rats. Quantitative macroscopic and microscopic analysis was performed to evaluate socket healing 8 days after extraction. Results: Pharmacologically treated rats showed significant inhibition of bone remodeling. Connective tissue/al-eolar bone ratio, osteoclast number and woven bone deposition were significantly reduced in group T compared to group C. Conversely, the proportion of necrotic bone was higher in group T compared to group C (0.8% and 0.3%, respectively. P = 0.031). ZOL plus DEX do not cause gross effects on socket healing at a macroscopic level. Conclusions: Our findings confirmed that exposure to ZOL plus DEX impairs alveolar wound repair. Inhibition of osteoclastic resorption of socket walls after tooth extraction and the inability to dispose of the necrotic bone may be considered the initial steps of MRONJ onset


No disponible


Subject(s)
Humans , Animals , Male , Rats , Bone Density Conservation Agents , Osteonecrosis , Dexamethasone , Diphosphonates , Tooth Extraction , Tooth Socket , Zoledronic Acid , Rats, Sprague-Dawley
2.
Support Care Cancer ; 24(2): 807-813, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26190360

ABSTRACT

PURPOSE: Laser therapy has been used for the prevention and management of medication-related ostenecrosis of the jaw (MRONJ). The aim of this paper was to investigate the action of laser therapy on extraction socket healing in rats in conditions at risk for MRONJ, evaluating the expression of markers of bone metabolism. METHODS: Thirty male Sprague-Dawley rats were divided in four groups: control group (C, n = 5), laser group (L, n = 5), treatment group (T, n = 10), and treatment plus laser group (T + L, n = 10). Rats of group T and T + L received zoledronate 0.1 mg/kg and dexamethasone 1 mg/kg every 2 days for 10 weeks. Rats of group C and L were infused with vehicle. After 9 weeks, the left maxillary molars were extracted in all rats. Rats of groups L and T + L received laser therapy (Nd:YAG, 1064 nm, 1.25 W, 15 Hz, 5 min, 14.37 J/cm(2)) in the socket area at days 0, 2, 4, and 6 after surgery. Western blot analysis was performed to evaluate the alveolar expression of osteopontin (OPN) and osteocalcin (OCN) 8 days after extraction. RESULTS: Rats of groups L and T + L showed a significant higher expression of OCN compared to rats of groups C and T (+348 and +400 %, respectively; P = 0.013 and P = 0.002, respectively). The expression of OPN did not show significant differences among the different groups. CONCLUSIONS: Our findings suggest that laser irradiation after tooth extraction can promote osteoblast differentiation, as demonstrated by the higher expression of OCN. Thus, laser irradiation could be considered a way to improve socket healing in conditions at risk for MRONJ development.


Subject(s)
Anti-Inflammatory Agents/pharmacology , Bone Density Conservation Agents/pharmacology , Dexamethasone/pharmacology , Diphosphonates/pharmacology , Imidazoles/pharmacology , Low-Level Light Therapy/methods , Osteocalcin/metabolism , Osteonecrosis/prevention & control , Osteopontin/metabolism , Tooth Extraction , Tooth Socket , Wound Healing , Animals , Anti-Inflammatory Agents/administration & dosage , Bone Density Conservation Agents/administration & dosage , Combined Modality Therapy , Dexamethasone/administration & dosage , Diphosphonates/administration & dosage , Imidazoles/administration & dosage , Male , Rats , Rats, Sprague-Dawley , Zoledronic Acid
SELECTION OF CITATIONS
SEARCH DETAIL
...