ABSTRACT
Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment for many diseases; however, it can induce complications such as Oral Mucositis (OM) and Graft-versus- Host Disease (GVHD). The neutrophil-lymphocyte ratio (NLR) is a peripheral biomarker of systemic inflammation and an independent prognostic factor for several inflammatory diseases. Aim: This study aimed to evaluate the association of NLR with OM and GVHD in patients undergoing allogeneic HSCT. Methods: Patients who underwent allogeneic HSCT at the Bone Marrow Transplant Service of the Hospital de Clínicas Complex of the Federal University of Paraná were included in the study. Socio-demographic data and blood counts were collected from patients' medical records. The NLR was calculated and associated with OM and GVHD. Results: 45 patients were included in the study. Although NLR was higher in patients with OM and oral GVHD, no statistical difference was observed, and no relationship between OM and GVHD with NLR could be stated. Conclusion: Although both OM and GVHD are associated with an inflammatory response as well as the immune system, it was not associated with NLR. Further investigation considering other variables related to HSCT might find possible associations, as it could favor patient management and prevention
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Stomatitis , Lymphocytes , Hematopoietic Stem Cell Transplantation , Graft vs Host Disease , NeutrophilsABSTRACT
Epilepsy is defined as a group of symptoms resulting from several neuronal complications ranging from changes in consciousness and motor activity to sensory phenomena and aberrant behaviors. This health problem has been associated with cases of stigma that can seriously affect the patient's quality of life. This study's main objectivewas to investigate the knowledge and attitudes regarding the treatmentof patients diagnosed with epilepsy by undergraduate dentistry students. The methodology was based on applyinga structured questionnaire with 17 close-endedquestions that evaluated information such as sociodemographic data, knowledge about epilepsy and social tolerance. The sample consisted of 397 students enrolled in the Dentistry course atFederal University of Paranáand divided into: group 1, students attending the 1st to the 7th semester of the course,and group 2, students in the last semester of the course. Group 1 students had more opportunities to care for patients with epilepsy than group 2. Most students expressed positive attitudes towardliving with people suffering from epilepsy and considered that they could not exercise certain professional activities. The question with the least number of correct answers dealt with the treatment of patients with the disease. Students' knowledge of epilepsy was low. However, the level of positive attitudes towardliving with this type of patient was considered high (AU).
A epilepsia é definida como um complexo de sintomas resultantes de diversas complicações neuronais que variam de alterações da consciência e da atividade motora até fenômenos sensoriais e comportamentos aberrantes. Esse problema de saúde tem sido associado a casos de estigma que podem repercutir seriamente na qualidade de vida do paciente. Este estudo teve por objetivo principal investigar o conhecimento e as atitudes em relação ao manejo de pacientes com diagnóstico de epilepsia dos estudantes de graduação do curso de Odontologia. A metodologia foi baseada na aplicação de um questionário estruturado com 17 perguntas fechadas que avaliaram informações como dados sociodemográficos, conhecimento sobre epilepsia e tolerância social. A amostra foi composta por 397 estudantes matriculados no curso de Odontologia da Universidade Federal do Paraná e dividida em: grupo 1, alunos cursando do 1º até o 7º semestre do curso e grupo 2, alunos do último semestre do curso. Os estudantes dogrupo 1 tiveram mais oportunidades para atender pacientes com epilepsia do que os do grupo 2. A maioria dos estudantes manifestou atitudes positivas em relação ao convívio com pessoas que sofrem de epilepsia e considerou que elas não poderiam exercer determinadas atividades profissionais. A questão com menor número de acertos tratava do tratamento de pacientes com a doença. O conhecimento dos estudantes em relação à epilepsia foi baixo. Porém, o nível de atitudes positivas em relação ao convívio com esse tipo de paciente foi considerado alto (AU).
