Subject(s)
Acidosis/chemically induced , Acute Kidney Injury/chemically induced , Enema/adverse effects , Hypernatremia/chemically induced , Hyperphosphatemia/chemically induced , Kidney Failure, Chronic/complications , Solutions/adverse effects , Acidosis/etiology , Acute Kidney Injury/etiology , Acute Kidney Injury/therapy , Adult , Colon , Comorbidity , Consciousness Disorders/etiology , Fluid Therapy , Foreign Bodies , Humans , Hypernatremia/etiology , Hyperphosphatemia/etiology , Intellectual Disability/complications , Male , Renal Dialysis , Urinary Tract Infections/complicationsABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Enema/adverse effects , Hypernatremia/etiology , Ketosis/etiology , Renal Insufficiency/etiology , ColonoscopyABSTRACT
We report a procedure for the online monitoring of aluminium in drinking water by flow injection analysis. The reaction used is the formation of a complex with morin. Under the working conditions, this can be accomplished in an ethanol-rich hydroalcoholic medium, which modifies the fluorescent characteristics of the complex, allowing the determination of aluminium concentrations higher than 3.1 microgl(-1), with a linear application range between 2 and 250 microgl(-1), an R.S.D. of 2.3% (n=10, 120 microgl(-1)) and a sampling frequency of 90 h(-1). The method can thus be considered one of the most sensitive and fastest for the continuous determination of aluminium. In the presence of anionic surfactants, the sensitivity of the determination is increased. In this form, aluminium is detected at concentrations higher than 2.8 microgl(-1), with a linear application range of 2-50 microgl(-1). The procedure was applied to the analysis of aluminium in drinking, river, and underground water. Under the proposed working conditions, only Fe(III), fluoride and phosphates interfere. The interference of Fe(III) can be avoided with hydroxylamine and that of phosphates and polyphosphates by acid digestion of the samples.
Subject(s)
Aluminum/analysis , Fresh Water/analysis , Online Systems , Ethanol/chemistry , Flavonoids/chemistry , Flavonoids/metabolism , Flow Injection Analysis , Fluorides/chemistry , Rivers , Spectrometry, Fluorescence , Water SupplyABSTRACT
Anderson-Fabry disease in an inherited X-linked metabolic disorder involving glycosphingolipid metabolism. Few data are available regarding cochlear involvement. Clinical manifestations of Fabry disease appeared on the first decade of life. The prognosis of males with Fabry disease is serious and life expectancy is limited; clinical evolution of heterozygous females is clearly better. We report a family with Fabry disease in several members. The mother, already dead, had two child which have been examined in our department; the male, without a risk of ototoxicity, or acoustic trauma, has progressive hearing loss, tinnitus and dizinness sometimes; the daughter, without a history of deafness, shows unilateral hearing loss on high-tone frequencies. It is important to emphasize these data to those physicians expert in children with Fabry disease because early enzyme replacement therapy intervention should offer increased possibilities of regression of the disease.
Subject(s)
Fabry Disease/complications , Fabry Disease/physiopathology , Hearing Loss, Sensorineural/etiology , Adult , Audiometry, Pure-Tone , Disease Progression , Female , Hearing Loss, Sensorineural/diagnosis , Humans , Male , Severity of Illness IndexABSTRACT
La enfermedad de Fabry-Anderson es un déficit genético ligado al cromosoma X, y se debe a un error del metabolismo de los glucoesfingolípidos. Los síntomas clínicos suelen aparecer a partir de la primera década de la vida y se han descrito pocos casos donde se identifique la afectación coclear. El pronóstico de la enfermedad en los hombres es grave y la expectativa de vida es limitada; el curso clínico de las mujeres heterocigotas es claramente mejor. Presentamos una familia de pacientes con la enfermedad de Fabry. La madre, fallecida, tuvo dos hijos que son el objeto de nuestro estudio; el varón, sin tener factores de riesgo de ototoxidad, ni trauma acústico, refiere una hipoacusia neurosensorial progresiva, acúfenos y ocasionalmente mareos; la hija, aunque no refiere hipoacusia, en la audiometría tonal se aprecia una pérdida auditiva unilateral en frecuencias agudas. Es importante llamar la atención de los especialistas implicados sobre las manifestaciones de la enfermedad de Fabry en el niño, especialmente porque el tratamiento de sustitución enzimática ha demostrado su efectividad para conseguir la regresión de la enfermedad
Anderson-Fabry disease in an inherited X-linked metabolic disorder involving glycosphingolipid metabolism. Few data are available regarding cochlear involvement. Clinical manifestations of Fabry disease appeared on the first decade of life. The prognosis of males with Fabry disease is serious and life expectancy is limited; clinical evolution of heterozygous females is clearly better. We report a family with Fabry disease in several members. The mother, already dead, had two child which have been examined in our department; the male, without a risk of ototoxicity, or acoustic trauma, has progressive hearing loss, tinnitus and dizinness sometimes; the daughter, without a history of deafness, shows unilateral hearing loss on high-tone frequencies. It is important to emphasize these data to those physicians expert in children with Fabry disease because early enzyme replacement therapy intervention should offer increased possibilities of regression of the disease
Subject(s)
Humans , Male , Female , Adult , Fabry Disease/physiopathology , Fabry Disease/complications , Hearing Loss, Sensorineural/etiology , Heterozygote , Glycosphingolipids/metabolism , Disease Progression , Severity of Illness IndexABSTRACT
Osteosclerotic myeloma is a plasma-cell dyscrasia characterized by osteosclerotic bone lesions, which may be associated with progressive demyelinating polyneuropathy. We describe a 49-year-old patient with rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma, who responded favorably to a combination of intravenous immunoglobulin and radiotherapy.
Subject(s)
Demyelinating Diseases/etiology , Immunoglobulin lambda-Chains/analysis , Immunoglobulins, Intravenous/therapeutic use , Lumbar Vertebrae , Myeloma Proteins/analysis , Osteosclerosis/etiology , POEMS Syndrome/complications , Peripheral Nervous System Diseases/etiology , Plasmacytoma/complications , Spinal Neoplasms/complications , Combined Modality Therapy , Demyelinating Diseases/physiopathology , Demyelinating Diseases/radiotherapy , Demyelinating Diseases/therapy , Disease Progression , Humans , Lumbar Vertebrae/pathology , Male , Middle Aged , Neoplastic Stem Cells/chemistry , Neural Conduction , POEMS Syndrome/diagnosis , Peripheral Nervous System Diseases/physiopathology , Peripheral Nervous System Diseases/radiotherapy , Peripheral Nervous System Diseases/therapy , Plasma Cells/chemistry , Plasmacytoma/diagnosis , Spinal Neoplasms/diagnosisABSTRACT
Presentation of one case of vesical involvement due to lymphoma in an 82-year old female which presented as a micturition syndrome, abdominal mass and later picture of obstructive uropathy with acute renal function impairment. Diagnosis was achieved by ultrasound and abdominal CAT, cystoscopy with of vesical biopsy, transvaginal mass biopsy and immunohistochemical techniques. The difficulties of a correct differential diagnosis with other vesical neoplasias as well as the need to differentiate primary from systemic vesical lymphoma were discussed, not only because of the separate prognosis but also for the different therapeutical approaches.
