ABSTRACT
El hamartoma fibroso de la infancia (HFI) es un tumor mesenquimal benigno infrecuente, que cursa como un nódulo subcutáneo único en niños menores de 2 años. Tiene una anatomía patológica característica, con un patrón organoide trifásico, y el tratamiento de elección es quirúrgico. Presentamos un caso con los hallazgos característicos de HFI, así como con cambios cutáneos (dilatación de las glándulas ecrinas) y un amplio estudiode inmunohistoquímica. Finalmente comentamos el diagnóstico diferencial de los tumores fibrosos de la infancia (AU)
Fibrous hamartoma of infancy (HFI) is a rare benign mesenchymal tumor. It is presented as a single subcutaneous tumor in children in the first two years of life. The lesion has a characteristic morphology with a triphasic organoid growth pattern, and the treatment of choice is local excision. We report a case with the distinctive histologic appearance of HFI and cutaneous changes (dilatation of eccrine glands) and a extensive immunohistochemestry study. Finally, differential diagnosis of fibrous tumors of infancy are discussed (AU)
Subject(s)
Humans , Male , Infant , Hamartoma/pathology , Neoplasms, Fibrous Tissue/pathology , Diagnosis, Differential , Integumentary System/pathologySubject(s)
Humans , Sarcoidosis/complications , Sarcoidosis/etiology , Sarcoidosis/physiopathology , Lupus Erythematosus, Cutaneous/diagnosis , Lupus Erythematosus, Cutaneous/etiology , Lupus Erythematosus, Cutaneous/therapy , Chilblains/diagnosis , Chilblains/radiotherapy , Lupus Erythematosus, Cutaneous/radiotherapy , Pulsed Radiofrequency Treatment , Lupus Erythematosus, Cutaneous/complications , Lupus Erythematosus, Cutaneous/prevention & control , Pulsed Radiofrequency Treatment/instrumentation , Pulsed Radiofrequency Treatment/methods , Pulsed Radiofrequency Treatment/trendsSubject(s)
Phototherapy , Skin Diseases/therapy , Female , Humans , Middle Aged , Sarcoidosis/complications , Skin Diseases/etiologyABSTRACT
Isotretinoin is the most effective treatment for severe acne, but there are several adverse effects associated with its use, some of them very exceptional (<1/10000). We report one case of hypoacusia and tinnitus in a 15-year-old boy treated with isotretinoin during 6 weeks, who quickly improved after isotretinoin withdrawal. Also, we comment other publications about hearing alterations in patients treated with isotretinoin and other retinoids.